Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Nature Medicine

Volumn 12, Issue 4, 2006, Pages 446-451

  Ito, Keisuke ^a   Hirao, Atsushi ^a,b,c   Arai, Fumio ^a   Takubo, Keiyo ^a   Matsuoka, Sahoko ^a   Miyamoto, Kana ^a   Ohmura, Masako ^a,b   Naka, Kazuhito ^b   Hosokawa, Kentaro ^a   Ikeda, Yasuo ^a   Suda, Toshio ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL POPULATION; CELL PROTECTION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSPLANTATION; WILD TYPE;

ANIMALS; BUTHIONINE SULFOXIMINE; CELL AGING; CELL CULTURE TECHNIQUES; CELL LINE; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; FREE RADICAL SCAVENGERS; HEMATOPOIETIC STEM CELLS; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; MICE; MICE, CONGENIC; MICE, INBRED C57BL; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

ANIMALIA;

EID: 33645730667     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1388     Document Type: Article

References (20)

1. Weissman, I.L. et al. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403 (2001).
2. Harman, D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300 (1956).
3. Schriner, S.E. et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 1909-1911 (2005).
4. Kujoth, G.C. et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309, 481-484 (2005).
5. Allsopp, R.C. et al. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat. Med. 9, 369-371 (2003).
6. Allsopp, R.C., Cheshier, S. & Weissman, I.L. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J. Exp. Med. 193, 917-924 (2001).
7. Griffith, O. Depletion of glutathione by inhibition of biosynthesis. Methods Enzymol. 77, 59-63 (1981).
8. Ito, K. et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997-1002 (2004).
9. Park, I.K. et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423, 302-305 (2003).
10. Wen-Sheng, W. ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. Oncogene 22, 955-963 (2003).
11. Iwasa, H., Han, J. & Ishikawa, F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8, 131-144 (2003).
12. Bulavin, D.V. et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 36, 343-350 (2004).
13. Arai, F. et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149-161 (2004).
14. Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804-1808 (2000).
15. Harrison, D.E. Normal function of transplanted marrow cell lines from aged mice. J. Gerontol. 30, 279-285 (1975).
16. Harrison, D.E. & Doubleday, J.W. Normal function of immunologic stem cells from aged mice. J. Immunol. 114, 1314-1317 (1975).
17. Tobiume, K. et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2, 222-228 (2001).
18. Balaban, R.S., Nemoto, S. & Finkel, T. Mitochondria, oxidants, and aging. Cell 120, 483-495 (2005).
19. Krishnamurthy, J. et al. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114, 1299-1307 (2004).
20. Verma, A. et al. Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J. Immunol. 168, 5984-5988 (2002).