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Volumn 120, Issue 4, 2005, Pages 497-512

DNA repair, genome stability, and aging

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; REACTIVE OXYGEN METABOLITE; SILENT INFORMATION REGULATOR PROTEIN 2; SINGLE STRANDED DNA;

EID: 13944249618     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.01.028     Document Type: Review
Times cited : (773)

References (115)
  • 1
    • 0141567744 scopus 로고    scopus 로고
    • RecQ helicases: Suppressors of tumorigenesis and premature aging
    • C.Z. Bachrati, and I.D. Hickson RecQ helicases: suppressors of tumorigenesis and premature aging Biochem. J. 374 2003 577 606
    • (2003) Biochem. J. , vol.374 , pp. 577-606
    • Bachrati, C.Z.1    Hickson, I.D.2
  • 3
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • R.S. Balaban, N. Shino, and F. Toren Mitochondria, oxidants, and aging this issue Cell 120 2005 483 495
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Shino, N.2    Toren, F.3
  • 4
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • G. Barja Free radicals and aging Trends Neurosci. 27 2004 595 600
    • (2004) Trends Neurosci. , vol.27 , pp. 595-600
    • Barja, G.1
  • 5
    • 0033972463 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
    • G. Barja, and A. Herrero Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals FASEB J. 14 2000 312 318
    • (2000) FASEB J. , vol.14 , pp. 312-318
    • Barja, G.1    Herrero, A.2
  • 6
    • 0036012789 scopus 로고    scopus 로고
    • ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage
    • A. Barzilai, G. Rotman, and Y. Shiloh ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage DNA Repair (Amst.) 1 2002 3 25
    • (2002) DNA Repair (Amst.) , vol.1 , pp. 3-25
    • Barzilai, A.1    Rotman, G.2    Shiloh, Y.3
  • 7
    • 3242881500 scopus 로고    scopus 로고
    • The cellular response to general and programmed DNA double strand breaks
    • C.H. Bassing, and F.W. Alt The cellular response to general and programmed DNA double strand breaks DNA Repair (Amst.) 3 2004 781 796
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 781-796
    • Bassing, C.H.1    Alt, F.W.2
  • 8
    • 1542781659 scopus 로고    scopus 로고
    • When cells get stressed: An integrative view of cellular senescence
    • I. Ben-Porath, and R.A. Weinberg When cells get stressed: an integrative view of cellular senescence J. Clin. Invest. 113 2004 8 13
    • (2004) J. Clin. Invest. , vol.113 , pp. 8-13
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 10
    • 0035340869 scopus 로고    scopus 로고
    • Trichothiodystrophy, a transcription syndrome
    • E. Bergmann, and J.M. Egly Trichothiodystrophy, a transcription syndrome Trends Genet. 17 2001 279 286
    • (2001) Trends Genet. , vol.17 , pp. 279-286
    • Bergmann, E.1    Egly, J.M.2
  • 11
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • G. Blander, and L. Guarente The Sir2 family of protein deacetylases Annu. Rev. Biochem. 73 2004 417 435
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 12
    • 0025841730 scopus 로고
    • Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice
    • R.T. Bronson, and R.D. Lipman Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice Growth Dev. Aging 55 1991 169 184
    • (1991) Growth Dev. Aging , vol.55 , pp. 169-184
    • Bronson, R.T.1    Lipman, R.D.2
  • 14
    • 0037204529 scopus 로고    scopus 로고
    • Between Scylla and Charybdis: P53 links tumor suppression and aging
    • J. Campisi Between Scylla and Charybdis: p53 links tumor suppression and aging Mech. Ageing Dev. 123 2002 567 573
    • (2002) Mech. Ageing Dev. , vol.123 , pp. 567-573
    • Campisi, J.1
  • 15
    • 0037302038 scopus 로고    scopus 로고
    • Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice
    • J. Cao, L. Venton, T. Sakata, and B.P. Halloran Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice J. Bone Miner. Res. 18 2003 270 277
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 270-277
    • Cao, J.1    Venton, L.2    Sakata, T.3    Halloran, B.P.4
  • 16
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
    • L. Cao, W. Li, S. Kim, S.G. Brodie, and C.X. Deng Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform Genes Dev. 17 2003 201 213
    • (2003) Genes Dev. , vol.17 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.X.5
  • 19
    • 0035853104 scopus 로고    scopus 로고
    • Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
    • H. Cohen, and D.A. Sinclair Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase Proc. Natl. Acad. Sci. USA 98 2001 3174 3179
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 3174-3179
    • Cohen, H.1    Sinclair, D.A.2
  • 22
    • 0035822641 scopus 로고    scopus 로고
    • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
    • F. d'Adda di Fagagna, M.P. Hande, W.M. Tong, D. Roth, P.M. Lansdorp, Z.Q. Wang, and S.P. Jackson Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells Curr. Biol. 11 2001 1192 1196
    • (2001) Curr. Biol. , vol.11 , pp. 1192-1196
    • D'Adda Di Fagagna, F.1    Hande, M.P.2    Tong, W.M.3    Roth, D.4    Lansdorp, P.M.5    Wang, Z.Q.6    Jackson, S.P.7
  • 25
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • T. de Lange Protection of mammalian telomeres Oncogene 21 2002 532 540
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 26
    • 0345276495 scopus 로고    scopus 로고
    • Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair
    • Y. Dong, M.A. Hakimi, X. Chen, E. Kumaraswamy, N.S. Cooch, A.K. Godwin, and R. Shiekhattar Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair Mol. Cell 12 2003 1087 1099
    • (2003) Mol. Cell , vol.12 , pp. 1087-1099
    • Dong, Y.1    Hakimi, M.A.2    Chen, X.3    Kumaraswamy, E.4    Cooch, N.S.5    Godwin, A.K.6    Shiekhattar, R.7
  • 28
    • 0036352911 scopus 로고    scopus 로고
    • Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts
    • S. Espejel, and M.A. Blasco Identification of telomere-dependent "senescence-like" arrest in mouse embryonic fibroblasts Exp. Cell Res. 276 2002 242 248
    • (2002) Exp. Cell Res. , vol.276 , pp. 242-248
    • Espejel, S.1    Blasco, M.A.2
  • 29
  • 30
    • 0037112834 scopus 로고    scopus 로고
    • Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    • S. Espejel, S. Franco, A. Sgura, D. Gae, S.M. Bailey, G.E. Taccioli, and M.A. Blasco Functional interaction between DNA-PKcs and telomerase in telomere length maintenance EMBO J. 21 2002 6275 6287
    • (2002) EMBO J. , vol.21 , pp. 6275-6287
    • Espejel, S.1    Franco, S.2    Sgura, A.3    Gae, D.4    Bailey, S.M.5    Taccioli, G.E.6    Blasco, M.A.7
  • 31
    • 9444243224 scopus 로고    scopus 로고
    • Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs
    • S. Espejel, P. Klatt, J.M. Murcia, J. Martin-Caballero, J.M. Flores, G. Taccioli, G. de Murcia, and M.A. Blasco Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs J. Cell Biol. 167 2004 627 638
    • (2004) J. Cell Biol. , vol.167 , pp. 627-638
    • Espejel, S.1    Klatt, P.2    Murcia, J.M.3    Martin-Caballero, J.4    Flores, J.M.5    Taccioli, G.6    De Murcia, G.7    Blasco, M.A.8
  • 32
  • 33
    • 0035839840 scopus 로고    scopus 로고
    • DNA double strand break repair and chromosomal translocation: Lessons from animal models
    • D.O. Ferguson, and F.W. Alt DNA double strand break repair and chromosomal translocation: lessons from animal models Oncogene 20 2001 5572 5579
    • (2001) Oncogene , vol.20 , pp. 5572-5579
    • Ferguson, D.O.1    Alt, F.W.2
  • 34
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • T. Finkel, and N.J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 408 2000 239 247
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 35
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • R.A. Frye Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins Biochem. Biophys. Res. Commun. 273 2000 793 798
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 793-798
    • Frye, R.A.1
  • 37
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
    • M. Goto Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing Mech. Ageing Dev. 98 1997 239 254
    • (1997) Mech. Ageing Dev. , vol.98 , pp. 239-254
    • Goto, M.1
  • 40
    • 0028113030 scopus 로고
    • Potential misinterpretations using models of accelerated aging
    • D.E. Harrison Potential misinterpretations using models of accelerated aging J. Gerontol. 49 1994 B245 B246
    • (1994) J. Gerontol. , vol.49
    • Harrison, D.E.1
  • 41
    • 0011555560 scopus 로고
    • Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
    • R.W. Hart, and R.B. Setlow Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species Proc. Natl. Acad. Sci. USA 71 1974 2169 2173
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , pp. 2169-2173
    • Hart, R.W.1    Setlow, R.B.2
  • 42
    • 4544377929 scopus 로고    scopus 로고
    • Accelerating aging by mouse reverse genetics: A rational approach to understanding longevity
    • P. Hasty, and J. Vijg Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity Aging Cell 3 2004 55 65
    • (2004) Aging Cell , vol.3 , pp. 55-65
    • Hasty, P.1    Vijg, J.2
  • 46
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 47
    • 1842789989 scopus 로고    scopus 로고
    • Mechanisms of cellular senescence in human and mouse cells
    • K. Itahana, J. Campisi, and G.P. Dimri Mechanisms of cellular senescence in human and mouse cells Biogerontology 5 2004 1 10
    • (2004) Biogerontology , vol.5 , pp. 1-10
    • Itahana, K.1    Campisi, J.2    Dimri, G.P.3
  • 49
    • 0035865143 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase
    • F.B. Johnson, R.A. Marciniak, M. McVey, S.A. Stewart, W.C. Hahn, and L. Guarente The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase EMBO J. 20 2001 905 913
    • (2001) EMBO J. , vol.20 , pp. 905-913
    • Johnson, F.B.1    Marciniak, R.A.2    McVey, M.3    Stewart, S.A.4    Hahn, W.C.5    Guarente, L.6
  • 50
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • M. Kaeberlein, M. McVey, and L. Guarente The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Genes Dev. 13 1999 2570 2580
    • (1999) Genes Dev. , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 51
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • 10.1371/journal.pbio.0020296
    • M. Kaeberlein, K.T. Kirkland, S. Fields, and B.K. Kennedy Sir2-independent life span extension by calorie restriction in yeast PLoS Biol. 2 2004 e296 10.1371/journal.pbio.0020296
    • (2004) PLoS Biol. , vol.2 , pp. 296
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 54
    • 0036829090 scopus 로고    scopus 로고
    • Cancer and aging: A model for the cancer promoting effects of the aging stroma
    • A. Krtolica, and J. Campisi Cancer and aging: a model for the cancer promoting effects of the aging stroma Int. J. Biochem. Cell Biol. 34 2002 1401 1414
    • (2002) Int. J. Biochem. Cell Biol. , vol.34 , pp. 1401-1414
    • Krtolica, A.1    Campisi, J.2
  • 55
    • 0344838431 scopus 로고    scopus 로고
    • Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta
    • K.Y. Kwan, P.B. Moens, and J.C. Wang Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta Proc. Natl. Acad. Sci. USA 100 2003 2526 2531
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2526-2531
    • Kwan, K.Y.1    Moens, P.B.2    Wang, J.C.3
  • 56
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • M. Lebel, and P. Leder A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity Proc. Natl. Acad. Sci. USA 95 1998 13097 13102
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 58
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • S.J. Lin, P.A. Defossez, and L. Guarente Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae Science 289 2000 2126 2128
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 60
    • 4544259868 scopus 로고    scopus 로고
    • Transcription - Guarding the genome by sensing DNA damage
    • M. Ljungman, and D.P. Lane Transcription - guarding the genome by sensing DNA damage Nat. Rev. Cancer 4 2004 727 737
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 727-737
    • Ljungman, M.1    Lane, D.P.2
  • 63
    • 0942290416 scopus 로고    scopus 로고
    • TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
    • A. Machwe, L. Xiao, and D.K. Orren TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA Oncogene 23 2004 149 156
    • (2004) Oncogene , vol.23 , pp. 149-156
    • MacHwe, A.1    Xiao, L.2    Orren, D.K.3
  • 66
    • 0141819143 scopus 로고    scopus 로고
    • An age-induced switch to a hyper-recombinational state
    • M.A. McMurray, and D.E. Gottschling An age-induced switch to a hyper-recombinational state Science 301 2003 1908 1911
    • (2003) Science , vol.301 , pp. 1908-1911
    • McMurray, M.A.1    Gottschling, D.E.2
  • 67
    • 0027378895 scopus 로고
    • Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
    • J. McWhir, J. Selfridge, D.J. Harrison, S. Squires, and D.W. Melton Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning Nat. Genet. 5 1993 217 224
    • (1993) Nat. Genet. , vol.5 , pp. 217-224
    • McWhir, J.1    Selfridge, J.2    Harrison, D.J.3    Squires, S.4    Melton, D.W.5
  • 68
    • 3242883729 scopus 로고    scopus 로고
    • The p53 response to DNA damage
    • D. Meek The p53 response to DNA damage DNA Repair (Amst) 3 2004 1049 1056
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1049-1056
    • Meek, D.1
  • 70
    • 4444327055 scopus 로고    scopus 로고
    • 'Accelerated aging': A primrose path to insight?
    • R.A. Miller 'Accelerated aging': a primrose path to insight? Aging Cell 3 2004 47 51
    • (2004) Aging Cell , vol.3 , pp. 47-51
    • Miller, R.A.1
  • 74
    • 2942637828 scopus 로고    scopus 로고
    • The Werner Syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
    • P.L. Opresko, M. Otterlei, J. Graakjaer, P. Bruheim, L. Dawut, S. Kolvraa, A. May, M.M. Seidman, and V.A. Bohr The Werner Syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2 Mol. Cell 14 2004 763 774
    • (2004) Mol. Cell , vol.14 , pp. 763-774
    • Opresko, P.L.1    Otterlei, M.2    Graakjaer, J.3    Bruheim, P.4    Dawut, L.5    Kolvraa, S.6    May, A.7    Seidman, M.M.8    Bohr, V.A.9
  • 75
    • 0037137177 scopus 로고    scopus 로고
    • The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro
    • D.K. Orren, S. Theodore, and A. Machwe The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro Biochemistry 41 2002 13483 13488
    • (2002) Biochemistry , vol.41 , pp. 13483-13488
    • Orren, D.K.1    Theodore, S.2    MacHwe, A.3
  • 76
    • 0037148403 scopus 로고    scopus 로고
    • ATM function and telomere stability
    • T.K. Pandita ATM function and telomere stability Oncogene 21 2002 611 618
    • (2002) Oncogene , vol.21 , pp. 611-618
    • Pandita, T.K.1
  • 78
    • 1542781658 scopus 로고    scopus 로고
    • Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
    • P.G. Pelicci Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? J. Clin. Invest. 113 2004 4 7
    • (2004) J. Clin. Invest. , vol.113 , pp. 4-7
    • Pelicci, P.G.1
  • 80
    • 0041508764 scopus 로고    scopus 로고
    • Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair
    • L.D. Rockwood, A. Nussenzweig, and S. Janz Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair Mutat. Res. 529 2003 51 58
    • (2003) Mutat. Res. , vol.529 , pp. 51-58
    • Rockwood, L.D.1    Nussenzweig, A.2    Janz, S.3
  • 81
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • B. Rogina, and S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998 16003
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 83
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • K. Rothkamm, I. Kruger, L.H. Thompson, and M. Lobrich Pathways of DNA double-strand break repair during the mammalian cell cycle Mol. Cell. Biol. 23 2003 5706 5715
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 86
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells
    • V.P. Schulz, V.A. Zakian, C.E. Ogburn, J. McKay, A.A. Jarzebowicz, S.D. Edland, and G.M. Martin Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells Hum. Genet. 97 1996 750 754
    • (1996) Hum. Genet. , vol.97 , pp. 750-754
    • Schulz, V.P.1    Zakian, V.A.2    Ogburn, C.E.3    McKay, J.4    Jarzebowicz, A.A.5    Edland, S.D.6    Martin, G.M.7
  • 87
    • 13944281226 scopus 로고    scopus 로고
    • Molecular functions of BRCA1 in the DNA damage response
    • R. Scully, A. Xie, and G. Nagaraju Molecular functions of BRCA1 in the DNA damage response Cancer Biol. Ther. 3 2004 521 527
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 521-527
    • Scully, R.1    Xie, A.2    Nagaraju, G.3
  • 91
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • Y. Shiloh, and M.B. Kastan ATM: genome stability, neuronal development, and cancer cross paths Adv. Cancer Res. 83 2001 209 254
    • (2001) Adv. Cancer Res. , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 92
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles - A cause of aging in yeast
    • D.A. Sinclair, and L. Guarente Extrachromosomal rDNA circles - a cause of aging in yeast Cell 91 1997 1033 1042
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 95
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • R.S. Sohal, and R. Weindruch Oxidative stress, caloric restriction, and aging Science 273 1996 59 63
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 96
    • 3242891189 scopus 로고    scopus 로고
    • The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together
    • T.H. Stracker, J.W. Theunissen, M. Morales, and J.H. Petrini The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together DNA Repair (Amst.) 3 2004 845 854
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 845-854
    • Stracker, T.H.1    Theunissen, J.W.2    Morales, M.3    Petrini, J.H.4
  • 97
    • 2442564700 scopus 로고    scopus 로고
    • Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
    • L.Q. Sun, D.W. Lee, Q. Zhang, W. Xiao, E.H. Raabe, A. Meeker, D. Miao, D.L. Huso, and R.J. Arceci Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG Genes Dev. 18 2004 1035 1046
    • (2004) Genes Dev. , vol.18 , pp. 1035-1046
    • Sun, L.Q.1    Lee, D.W.2    Zhang, Q.3    Xiao, W.4    Raabe, E.H.5    Meeker, A.6    Miao, D.7    Huso, D.L.8    Arceci, R.J.9
  • 98
    • 0030671254 scopus 로고    scopus 로고
    • Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus
    • H. Tahara, Y. Tokutake, S. Maeda, H. Kataoka, T. Watanabe, M. Satoh, T. Matsumoto, M. Sugawara, T. Ide, and M. Goto Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus Oncogene 15 1997 1911 1920
    • (1997) Oncogene , vol.15 , pp. 1911-1920
    • Tahara, H.1    Tokutake, Y.2    Maeda, S.3    Kataoka, H.4    Watanabe, T.5    Satoh, M.6    Matsumoto, T.7    Sugawara, M.8    Ide, T.9    Goto, M.10
  • 99
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • M. Takata, M.S. Sasaki, E. Sonoda, C. Morrison, M. Hashimoto, H. Utsumi, Y. Yamaguchi-Iwai, A. Shinohara, and S. Takeda Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells EMBO J. 17 1998 5497 5508
    • (1998) EMBO J. , vol.17 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6    Yamaguchi-Iwai, Y.7    Shinohara, A.8    Takeda, S.9
  • 100
    • 1542309071 scopus 로고    scopus 로고
    • Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF
    • M. Tian, R. Shinkura, N. Shinkura, and F.W. Alt Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF Mol. Cell. Biol. 24 2004 1200 1205
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1200-1205
    • Tian, M.1    Shinkura, R.2    Shinkura, N.3    Alt, F.W.4
  • 101
    • 3242877915 scopus 로고    scopus 로고
    • The DNA double-strand break response pathway: Becoming more BRCAish than ever
    • N.S. Ting, and W.H. Lee The DNA double-strand break response pathway: becoming more BRCAish than ever DNA Repair (Amst.) 3 2004 935 944
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 935-944
    • Ting, N.S.1    Lee, W.H.2
  • 102
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • H.A. Tissenbaum, and L. Guarente Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature 410 2001 227 230
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 105
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • K. Valerie, and L.F. Povirk Regulation and mechanisms of mammalian double-strand break repair Oncogene 22 2003 5792 5812
    • (2003) Oncogene , vol.22 , pp. 5792-5812
    • Valerie, K.1    Povirk, L.F.2
  • 107
    • 4944245398 scopus 로고    scopus 로고
    • Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • A. Vaquero, M. Scher, D. Lee, H. Erdjument-Bromage, P. Tempst, and D. Reinberg Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin Mol. Cell 16 2004 93 105
    • (2004) Mol. Cell , vol.16 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5    Reinberg, D.6
  • 108
    • 0033953142 scopus 로고    scopus 로고
    • Somatic mutations and aging: A re-evaluation
    • J. Vijg Somatic mutations and aging: a re-evaluation Mutat. Res. 447 2000 117 135
    • (2000) Mutat. Res. , vol.447 , pp. 117-135
    • Vijg, J.1
  • 112


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