Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

Journal of Cell Biology

Volumn 175, Issue 6, 2006, Pages 913-923

  Pelicano, Hélène ^a   Xu, Rui Hua ^a,b   Du, Min ^a   Feng, Li ^a   Sasaki, Ryohei ^a,c   Carew, Jennifer S ^a   Hu, Yumin ^a   Ramdas, Latha ^a   Hu, Limei ^a   Keating, Michael J ^a   Zhang, Wei ^a   Plunkett, William ^a   Huang, Peng ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DOXORUBICIN; MITOCHONDRIAL DNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; VINCRISTINE;

ARTICLE; CANCER CELL; CELL SURVIVAL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME INACTIVATION; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL HYPOXIA; CELL RESPIRATION; CELL SURVIVAL; DNA, MITOCHONDRIAL; ENZYME ACTIVATION; GLYCOLYSIS; HUMANS; MITOCHONDRIA; NAD; NEOPLASMS; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 33845718704     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200512100     Document Type: Article

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