Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Nature

Volumn 431, Issue 7011, 2004, Pages 997-1002

  Ito, Keisuke ^a   Hirao, Atsushi ^a   Arai, Fumio ^a   Matsuoka, Sahoko ^a   Takubo, Keiyo ^a   Hamaguchi, Isao ^a   Nomiyama, Kana ^a   Hosokawa, Kentaro ^a   Sakurada, Kazuhiro ^b   Nakagata, Naomi ^c   Ikeda, Yasuo ^a   Mak, Tak W ^d   Suda, Toshio ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL CULTURE; GENES; IMMUNOLOGY; MUTAGENESIS; OXIDATION; OXYGEN;

ANTI-OXIDATIVE AGENTS; IMMUNODEFICIENCY; SELF-RENEWAL CAPACITY;

GENETIC ENGINEERING;

ATM PROTEIN; PROTEIN P16; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN;

MEDICINE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; ATAXIA TELANGIECTASIA; ATM GENE; AUTOSOMAL RECESSIVE DISORDER; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CEREBELLAR ATAXIA; CONTROLLED STUDY; DNA DAMAGE; GENETIC STABILITY; HEMATOPOIETIC STEM CELL; IMMUNE DEFICIENCY; INCIDENCE; LYMPHOMA; MOUSE; MUTATOR GENE; NONHUMAN; OCULOCUTANEOUS TELANGIECTASIA; OXIDATIVE STRESS; PREMATURE AGING; PRIORITY JOURNAL; RETINOBLASTOMA; SPERMATOGENESIS; TELANGIECTASIA; TELOMERE; TUMOR SUPPRESSOR GENE;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINEAGE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA-BINDING PROTEINS; GENE DELETION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 7244250309     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02989     Document Type: Article

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