Mutations in the WRN gene in mice accelerate mortality in a p53-null background

Molecular and Cellular Biology

Volumn 20, Issue 9, 2000, Pages 3286-3291

  Lombard, David B ^a   Beard, Caroline ^b   Johnson, Brad ^a   Marciniak, Robert A ^a   Dausman, Jessie ^b   Bronson, Roderick ^d   Buhlmann, Janet E ^c   Lipman, Ruth ^d   Curry, Ruth ^b   Sharpe, Arlene ^c   Jaenisch, Rudolf ^d   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION; GENE MUTATION; LIFESPAN; MOLECULAR CLONING; MORTALITY; MOUSE; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN DOMAIN; WERNER SYNDROME;

4-NITROQUINOLINE-1-OXIDE; ANIMALS; BLOTTING, WESTERN; CAMPTOTHECIN; CELL AGING; CELL DIVISION; CELLS, CULTURED; CLONING, MOLECULAR; DNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; FIBROBLASTS; GENE LIBRARY; LIFE EXPECTANCY; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; QUINOLONES; RECQ HELICASES; SPLEEN; TIME FACTORS; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 17544402913     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.9.3286-3291.2000     Document Type: Article

References (26)

1. Blander, G., J. Kipnis, J. F. Leal, C. E. Yu, G. D. Schellenberg, and M. Oren. 1999. Physical and functional interaction between p53 and the Werner's syndrome protein. J. Biol. Chem. 274:29463-29469.
2. Fukuchi, K., G. M. Martin, and R. J. Monnat, Jr. 1989. Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. USA 86:5893-5897.
3. Fukuchi, K., K. Tanaka, Y. Kumahara, K. Marumo, M. B. Pride, G. M. Martin, and R. J. Monnat, Jr. 1990. Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum. Genet. 84:249-252.
4. Gebhart, E., R. Bauer, U. Raub, M. Schinzel, K. W. Ruprecht, and J. B. Jonas. 1988. Spontaneous and induced chromosomal instability in Werner syndrome. Hum. Genet. 80:135-139.
5. Hoehn, H., E. M. Bryant, K. Au, T. H. Norwood, H. Boman, and G. M. Martin. 1975. Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet. Cell Genet. 15:282-298.
6. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
7. Imamura, O., K. Ichikawa, Y. Yamabe, M. Goto, M. Sugawara, and Y. Furuichi. 1997. Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization. Genomics 41:298-300.
8. Jacks, T., L. Remington, B. O. Williams, E. M. Schmitt, S. Halachmi, R. T. Bronson, and R. A. Weinberg. 1994. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4:1-7.
9. Kipling, D., and H. J. Cooke. 1990. Hypervariable ultra-long telomeres in mice. Nature 347:400-402.
10. Lebel, M., and P. Leder. 1998. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc. Natl. Acad. Sci. USA 95:13097-13102.
11. Li, E., T. H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926.
12. Marciniak, R. A., D. B. Lombard, F. B. Johnson, and L. Guarente. 1998. Nucleolar localization of the Werner syndrome protein in human cells. Proc. Natl. Acad. Sci. USA 95:6887-6892.
13. Martin, G. M., C. A. Sprague, and C. J. Epstein. 1970. Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab. Investig. 23:86-92.
14. Monnat, R. J., Jr., A. F. Hackmann, and T. A. Chiaverotti. 1992. Nucleotide sequence analysis of human hypoxanthine phosphoribosyltransferase (HPRT) gene deletions. Genomics 13:777-787.
15. Moser, M. J., J. Oshima, and R. J. Monnat, Jr. 1999. WRN mutations in Werner syndrome. Hum. Mutat. 13:271-279.
16. Ogburn, C. E., J. Oshima, M. Poot, R. Chen, K. E. Hunt, K. A. Gollahon, P. S. Rabinovitch, and G. M. Martin. 1997. An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum. Genet. 101:121-125.
17. Prowse, K. R., and C. W. Greider. 1995. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA 92:4818-4822.
18. Salk, D. 1982. Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations. Hum. Genet. 62:1-5.
19. Salk, D., K. Au, H. Hoehn, M. R. Stenchever, and G. M. Martin. 1981. Evidence of clonal attenuation, clonal succession, and clonal expansion in mass cultures of aging Werner's syndrome skin fibroblasts. Cytogenet. Cell Genet. 30:108-117.
20. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
21. Scappaticci, S., D. Cerimele, and M. Fraccaro. 1982. Clonal structural chromosomal rearrangements in primary fibroblast cultures and in lymphocytes of patients with Werner's Syndrome. Hum. Genet. 62:16-24.
22. Schulz, V. P., V. A. Zakian, C. E. Ogburn, J. McKay, A. A. Jarzebowicz, S. D. Edland, and G. M. Martin. 1996. Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum. Genet. 97:750-754.
23. Spillare, E. A., A. I. Robles, X. W. Wang, J. C. Shen, C. E. Yu, G. D. Schellenberg, and C. C. Harris. 1999. p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes Dev. 13:1355-1360.
24. Tahara, H., Y. Tokutake, S. Maeda, H. Kataoka, T. Watanabe, M. Satoh, T. Matsumoto, M. Sugawara, T. Ide, M. Goto, Y. Furuichi, and M. Sugimoto. 1997. Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus. Oncogene 15:1911-1920.
25. Weeda, G., I. Donker, J. de Wit, H. Morreau, R. Janssens, C. J. Vissers, A. Nigg, H. van Steeg, D. Bootsma, and J. H. J. Hoeijmakers. 1997. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr. Biol. 7:427-439.
26. Yu, C. E., J. Oshima, Y. H. Fu, E. M. Wijsman, F. Hisama, R. Alisch, S. Matthews, J. Nakura, T. Miki, S. Ouais, G. M. Martin, J. Mulligan, and G. D. Schellenberg. 1996. Positional cloning of the Werner's syndrome gene. Science 272:258-262.