Aging and genome maintenance: Lessons from the mouse?

Science

Volumn 299, Issue 5611, 2003, Pages 1355-1359

  Hasty, Paul ^a   Campisi, Judith ^b,c   Hoeijmakers, Jan ^d   Van Steeg, Harry ^e   Vijg, Jan ^a,f  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^f SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; YEAST;

GENOME MAINTENANCE;

GENETIC ENGINEERING;

DNA; PROTEIN P66;

AGING; GENOME;

AGING; ANIMAL CELL; ANIMAL TISSUE; CELL VIABILITY; DNA DAMAGE; ENERGY METABOLISM; EXCISION REPAIR; GENE MUTATION; GENETIC ANALYSIS; GENETIC CONSERVATION; LIFESPAN; LONGEVITY; MOLECULAR MODEL; MOUSE; NEMATODE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; YEAST;

AGING; AGING, PREMATURE; ANIMALS; APOPTOSIS; CELL AGING; DNA DAMAGE; DNA HELICASES; DNA REPAIR; GENOME; GENOME, HUMAN; HUMANS; LONGEVITY; MICE; MUTATION; REACTIVE OXYGEN SPECIES; RECQ HELICASES; SYNDROME; TELOMERE; TRANSCRIPTION, GENETIC;

ANIMALIA; NEMATODA;

EID: 0037470542     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079161     Document Type: Review

References (58)

1. D. Harman, J. Gerontol. 11, 298 (1956).
2. T. Finkel, UBMB Life 52, 3 (2001).
3. SHC mice. Science's SAGE KE 2003, tg4 (26 February 2003); http://sageke.sciencemag.org/ cgi/content/full/sageke;2003/8/tg4
4. E. Migliaccio et al., Nature 402, 309 (1999).
5. M. Holzenberger et al., Nature 421, 182 (2003).
6. E. J. Masoro, . N. Austad, J. Gerontol. A 51, B387 (1996).
7. G. J. Lithgow, M. S. Gill, Nature 421, 125 (2003).
8. J. H. Hoeijmakers, Nature 411, 366 (2001).
9. G. M. Martin, in Birth Defects: Original Article Series (The National Foundation, New York, 1978), vol. 14, pp. 5-39.
10. R. S. Tebbs et al., Dev. Biol. 208, 513 (1999).
11. B. P. Engelward et al., Proc. Natl. Acad. Sci. U.S.A. 94, 13087 (1997).
12. A. de Vries et al., Nature 377, 169 (1995).
13. J. de Boer et al., Science 296, 1276 (2002).
14. C.-S. Lim, XPD (R722W) TTD mice. Science's SAGE KE 2002, tg8 (15 May 2002); http://sageke.sciencemag. org/cgi/content/full/sageke;2002/19/tg8.
15. G. T. van der Horst et al., Cell 89, 425 (1997).
16. M. Murai et al., Proc. Natl. Acad. Sci. U.S.A. 98, 13379 (2001).
17. D. C. van Gent, J. H. Hoeijmakers, R. Kanaar, Nature Rev. Genet. 2, 196 (2001).
18. D. Noshous et al., Cell 105, 177 (2001).
19. -/- mice. Science's SAGE KE 2002, tg5 (10 April 2002); http://sageke.sciencemag.org/cgi/ content/full/sageke;2002/14/tg5.
20. -/- mice. Science's SAGE KE 2002, tg6 (10 April 2002); http://sageke.sciencemag.org/cgi/ content/full/sageke;2002/14/t96.
21. H. Vogel, D. S. Lim, G. Karsenty, M. Finegoid, P. Hasty, Proc. Natl. Acad. Sci. U.S.A. 96, 10770 (1999).
22. D. S. Lim et al., Mol. Cell. Biol. 20, 3772 (2000).
23. Z. E. Karanjawata, N. Murphy, D. R. Hinton, C. L. Hsieh, M. R. Lieber, Curr. Biol. 12, 397 (2002).
24. S. J. Boulton, S. P. Jackson, EMBO J. 17, 1819 (1998).
25. H. L. Hsu, D. Gilley, E. H. Blackburn, D. J. Chen, Proc. Natl. Acad, Sci. U.S.A. 96, 12454 (1999).
26. S. M. Bailey et al., Proc. Natl. Acad. Sci. U.S.A. 96, 14899 (1999).
27. G. C. Li et al., Mol. Cell 2, 1 (1998).
28. G. Weeda et al., Curr. Biol. 7, 427 (1997).
29. L. J. Niedernhofer, J. H. Hoeijmakers, in preparation.
30. M. J. McEachern, A. Krauskopf, E. H. Blackburn, Annu. Rev. Genet. 34, 331 (2000).
31. -/- mice. Science's SAGE KE 2003, tg2 (26 February 2003); http://sageke.sciencemag.org/ cgi/content/full/sageke;2003/8/tg2.
32. H. W. Lee et al., Nature 392, 569 (1998).
33. K. L. Rudolph et al., Cell 96, 701 (1999).
34. K. K. Wong, Nature 421, 643 (2002).
35. N. Lebel, P. Leder, Proc. Natl. Acad. Sci. U.S.A. 95, 13097 (1998).
36. H. sapiens WRN, Science's SAGE KE, GdbGene189; http://sageke.sciencemag.org/cgi/genedata/sageke GdbGene;189.
37. C. E. Yu et al., Science 272, 258 (1996).
38. K. Fukuchi, G. M. Martin, R. J. Monnat Jr., Proc. Natl. Acad. Sci. U.S.A. 86, 5893 (1989).
39. M. Lebel, E. A. Spillare, C. C. Harris, P. Leder, J. Biol. Chem. 274, 37795 (1999).
40. M. P. Cooper et al., Genes Dev. 14, 907 (2000).
41. H. van Remmen, W. F. Ward, R. Sabia, A. Richardson, in Handbook of Physiology: Aging, E. J. Masoro, Ed. (Oxford Univ. Press. New York, 1995), pp. 171-234.
42. R. A. DePinho, Nature 408, 248 (2000).
43. M. E. Dolle, J. Vijg, Genome Res. 12, 1732 (2002).
44. J. C. Reed, Curr. Opin. Oncol. 11, 68 (1999).
45. J. Campisi, Trends Cell Biol. 11, S27 (2001).
46. -, unpublished data.
47. L. Chin et al., Cell 97, 527 (1999).
48. A. Krtolica, S. Parrinello, S. Lockett, P. Y. Desprez, J. Campisi, Proc. Natl. Acad. Sci. U.S.A. 98, 12072 (2001).
49. M. Lebel, R. D. Cardiff, P. Leder, Cancer Res. 61, 1816 (2001).
50. S. D. Tyner et al., Nature 415, 45 (2002).
51. I. Garcia-Cao et al., EMBO J. 21, 6225 (2002).
52. T. B. Kirkwood, Nature 270, 301 (1977).
53. We thank R. McCarter, D. Nichols, and H. Warner for valuable discussions. Supported by National Institute on Aging grant AG17242.
54. Related Resources: C. A. Walter, R. B. Walter, J. R. McCarrey, Germline genomes - a biological fountain of youth? Science's SAGE KE 2003, pe4 (26 February 2003); http://sageke.sciencemag.org/cgi/content/full/ sageke;2003/8/pe4; P. V. Shcherbakova, K. Bebenek, T. A. Kunkel, Functions of eukaryotic DNA polymerases. Science's SAGE KE 2003, re2 (26 February 2003); http:// sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ re3; Genes/Interventions Database. Science's SAGE KE; http://sageke.sciencemag.org/cgi/genesdb; K. Morgan, Laid to waste. Science's SAGE KE 2003, nw50 (17 April 2002); http://sageke.sciencemag.org/cgi/content/ abstract/sageke:2002/15/nw50: C. eydel, Stay mellow, Stay young. Science's SAGE KE 2003, nf5 (20 March 2002); http:/sageke.sciencemag.org/cgi/content/full/ sageke;2002/11/nf5.
55. Related Resources: C. A. Walter, R. B. Walter, J. R. McCarrey, Germline genomes - a biological fountain of youth? Science's SAGE KE 2003, pe4 (26 February 2003); http://sageke.sciencemag.org/cgi/content/full/ sageke;2003/8/pe4; P. V. Shcherbakova, K. Bebenek, T. A. Kunkel, Functions of eukaryotic DNA polymerases. Science's SAGE KE 2003, re2 (26 February 2003); http:// sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ re3; Genes/Interventions Database. Science's SAGE KE; http://sageke.sciencemag.org/cgi/genesdb; K. Morgan, Laid to waste. Science's SAGE KE 2003, nw50 (17 April 2002); http://sageke.sciencemag.org/cgi/content/ abstract/sageke:2002/15/nw50: C. eydel, Stay mellow, Stay young. Science's SAGE KE 2003, nf5 (20 March 2002); http:/sageke.sciencemag.org/cgi/content/full/ sageke;2002/11/nf5.
56. Related Resources: C. A. Walter, R. B. Walter, J. R. McCarrey, Germline genomes - a biological fountain of youth? Science's SAGE KE 2003, pe4 (26 February 2003); http://sageke.sciencemag.org/cgi/content/full/ sageke;2003/8/pe4; P. V. Shcherbakova, K. Bebenek, T. A. Kunkel, Functions of eukaryotic DNA polymerases. Science's SAGE KE 2003, re2 (26 February 2003); http:// sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ re3; Genes/Interventions Database. Science's SAGE KE; http://sageke.sciencemag.org/cgi/genesdb; K. Morgan, Laid to waste. Science's SAGE KE 2003, nw50 (17 April 2002); http://sageke.sciencemag.org/cgi/content/ abstract/sageke:2002/15/nw50: C. eydel, Stay mellow, Stay young. Science's SAGE KE 2003, nf5 (20 March 2002); http:/sageke.sciencemag.org/cgi/content/full/ sageke;2002/11/nf5.
57. Related Resources: C. A. Walter, R. B. Walter, J. R. McCarrey, Germline genomes - a biological fountain of youth? Science's SAGE KE 2003, pe4 (26 February 2003); http://sageke.sciencemag.org/cgi/content/full/ sageke;2003/8/pe4; P. V. Shcherbakova, K. Bebenek, T. A. Kunkel, Functions of eukaryotic DNA polymerases. Science's SAGE KE 2003, re2 (26 February 2003); http:// sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ re3; Genes/Interventions Database. Science's SAGE KE; http://sageke.sciencemag.org/cgi/genesdb; K. Morgan, Laid to waste. Science's SAGE KE 2003, nw50 (17 April 2002); http://sageke.sciencemag.org/cgi/content/ abstract/sageke:2002/15/nw50: C. eydel, Stay mellow, Stay young. Science's SAGE KE 2003, nf5 (20 March 2002); http:/sageke.sciencemag.org/cgi/content/full/ sageke;2002/11/nf5.
58. Related Resources: C. A. Walter, R. B. Walter, J. R. McCarrey, Germline genomes - a biological fountain of youth? Science's SAGE KE 2003, pe4 (26 February 2003); http://sageke.sciencemag.org/cgi/content/full/ sageke;2003/8/pe4; P. V. Shcherbakova, K. Bebenek, T. A. Kunkel, Functions of eukaryotic DNA polymerases. Science's SAGE KE 2003, re2 (26 February 2003); http:// sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ re3; Genes/Interventions Database. Science's SAGE KE; http://sageke.sciencemag.org/cgi/genesdb; K. Morgan, Laid to waste. Science's SAGE KE 2003, nw50 (17 April 2002); http://sageke.sciencemag.org/cgi/content/ abstract/sageke:2002/15/nw50: C. eydel, Stay mellow, Stay young. Science's SAGE KE 2003, nf5 (20 March 2002); http:/sageke.sciencemag.org/cgi/content/full/ sageke;2002/11/nf5.