SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

Cell

Volumn 126, Issue 5, 2006, Pages 941-954

  Haigis, Marcia C ^a   Mostoslavsky, Raul ^b   Haigis, Kevin M ^a   Fahie, Kamau ^c   Christodoulou, Danos C ^a   Murphy, Andrew J ^d   Valenzuela, David M ^d   Yancopoulos, George D ^d   Karow, Margaret ^d   Blander, Gil ^a   Wolberger, Cynthia ^c   Prolla, Tomas A ^e   Weindruch, Richard ^f   Alt, Frederick W ^b   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d REGENERON PHARMACEUTICALS INC   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE TRIPHOSPHATE; AMINO ACID; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; INSULIN; MITOCHONDRIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHODIESTERASE; SIRT4 PROTEIN; SIRTUIN; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CANCER CELL; CONTROLLED STUDY; DIETARY INTAKE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REPRESSION; FEMALE; INSULIN RELEASE; INSULINOMA; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN METABOLISM;

MAMMALIA;

EID: 33748316536     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.06.057     Document Type: Article

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