SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein

Molecular Cell

Volumn 27, Issue 1, 2007, Pages 149-162

  Yuan, Zhigang ^a   Zhang, Xiaohong ^a   Sengupta, Nilanjan ^a   Lane, William S ^b   Seto, Edward ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

DNA; PROTEINS

Indexed keywords

ATM PROTEIN; HISTONE DEACETYLASE; NIBRIN; NUCLEASE; SIRTUIN;

ACETYLATION; ARTICLE; CELL CYCLE S PHASE; CELL SURVIVAL; DEACETYLATION; DNA DAMAGE; IONIZING RADIATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ACETYLATION; ANIMALS; CELL CYCLE PROTEINS; CELL SURVIVAL; DNA; HELA CELLS; HISTONE DEACETYLASES; HUMANS; MICE; NUCLEAR PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; RADIATION, IONIZING; SIRTUINS;

EID: 34250897968     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.05.029     Document Type: Article

References (55)

1. Bakkenist C.J., and Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421 (2003) 499-506
2. Blander G., and Guarente L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73 (2004) 417-435
3. Blander G., Olejnik J., Krzymanska-Olejnik E., McDonagh T., Haigis M., Yaffe M.B., and Guarente L. SIRT1 shows no substrate specificity in vitro. J. Biol. Chem. 280 (2005) 9780-9785
4. Boisvert F.M., Dery U., Masson J.Y., and Richard S. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev. 19 (2005) 671-676
5. Brand M., Moggs J.G., Oulad-Abdelghani M., Lejeune F., Dilworth F.J., Stevenin J., Almouzni G., and Tora L. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. EMBO J. 20 (2001) 3187-3196
6. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
7. Cerosaletti K., Wright J., and Concannon P. Active role for nibrin in the kinetics of atm activation. Mol. Cell. Biol. 26 (2006) 1691-1699
8. Chen W.Y., Wang D.H., Yen R.C., Luo J., Gu W., and Baylin S.B. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123 (2005) 437-448
9. Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., and Chua K.F. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100 (2003) 10794-10799
10. Digweed M., and Sperling K. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst.) 3 (2004) 1207-1217
11. Dong Z., Zhong Q., and Chen P.L. The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. J. Biol. Chem. 274 (1999) 19513-19516
12. Gatei M., Young D., Cerosaletti K.M., Desai-Mehta A., Spring K., Kozlov S., Lavin M.F., Gatti R.A., Concannon P., and Khanna K. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25 (2000) 115-119
13. Giannakou M.E., and Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 14 (2004) 408-412
14. Glozak M.A., Sengupta N., Zhang X., and Seto E. Acetylation and deacetylation of non-histone proteins. Gene 363 (2005) 15-23
15. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature 444 (2006) 868-874
16. Haigis M.C., and Guarente L.P. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20 (2006) 2913-2921
17. Ikura T., Ogryzko V.V., Grigoriev M., Groisman R., Wang J., Horikoshi M., Scully R., Qin J., and Nakatani Y. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102 (2000) 463-473
18. Jazayeri A., McAinsh A.D., and Jackson S.P. Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 101 (2004) 1644-1649
19. Kamel C., Abrol M., Jardine K., He X., and McBurney M.W. SirT1 fails to affect p53-mediated biological functions. Aging Cell 5 (2006) 81-88
20. Kao G.D., McKenna W.G., Guenther M.G., Muschel R.J., Lazar M.A., and Yen T.J. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. J. Cell Biol. 160 (2003) 1017-1027
21. Kouzarides T. Acetylation: a regulatory modification to rival phosphorylation?. EMBO J. 19 (2000) 1176-1179
22. Lee J.H., and Paull T.T. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304 (2004) 93-96
23. Lee J.H., and Paull T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 (2005) 551-554
24. Lim D.S., Kim S.T., Xu B., Maser R.S., Lin J., Petrini J.H., and Kastan M.B. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404 (2000) 613-617
25. Liszt G., Ford E., Kurtev M., and Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J. Biol. Chem. 280 (2005) 21313-21320
26. Lombard D.B., Chua K.F., Mostoslavsky R., Franco S., Gostissa M., and Alt F.W. DNA repair, genome stability, and aging. Cell 120 (2005) 497-512
27. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
28. Michishita E., Park J.Y., Burneskis J.M., Barrett J.C., and Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell 16 (2005) 4623-4635
29. Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., Liu P., Mostoslavsky G., Franco S., Murphy M.M., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124 (2006) 315-329
30. Nemoto S., Fergusson M.M., and Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α. J. Biol. Chem. 280 (2005) 16456-16460
31. North B.J., Marshall B.L., Borra M.T., Denu J.M., and Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11 (2003) 437-444
32. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
33. Roth S.Y., Denu J.M., and Allis C.D. Histone acetyltransferases. Annu. Rev. Biochem. 70 (2001) 81-120
34. Sharma V.M., Tomar R.S., Dempsey A.E., and Reese J.C. Histone deacetylase RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. Mol. Cell. Biol. 27 (2007) 3199-3210
35. Shiloh Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31 (1997) 635-662
36. Solomon J.M., Pasupuleti R., Xu L., McDonagh T., Curtis R., DiStefano P.S., and Huber L.J. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol. Cell. Biol. 26 (2006) 28-38
37. Sterner D.E., and Berger S.L. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64 (2000) 435-459
38. Stracker T.H., Morales M., Couto S.S., Hussein H., and Petrini J.H.J. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 447 (2007) 218-221
39. Tamburini B.A., and Tyler J.K. Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Mol. Cell. Biol. 25 (2005) 4903-4913
40. Tauchi H., Matsuura S., Kobayashi J., Sakamoto S., and Komatsu K. Nijmegen Breakage Syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 21 (2002) 8967-8980
41. Tauchi H., Kobayashi J., Morishima K., van Gent D.C., Shiraishi T., Verkaik N.S., vanHeems D., Ito E., Nakamura A., Sonoda E., et al. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature 420 (2002) 93-98
42. van der Burgt I., Chrzanowska K.H., Smeets D., and Weemaes C. Nijmegen breakage syndrome. J. Med. Genet. 33 (1996) 153-156
43. Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., and Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 (2004) 93-105
44. Vaquero A., Scher M.B., Lee D.H., Sutton A., Cheng H.L., Alt F.W., Serrano L., Sternglanz R., and Reinberg D. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 20 (2006) 1256-1261
45. Varon R., Vissinga C., Platzer M., Cerosaletti K.M., Saar K., Beckmann G., Seemanova E., Cooper P.R., Nowak N.J., Stumm M., et al. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93 (1998) 467-476
46. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
47. Wang C., Chen L., Hou X., Li Z., Kabra N., Ma Y., Nemoto S., Finkel T., Gu W., Cress W.D., and Chen J. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 8 (2006) 1025-1031
48. Wu X., Ranganathan V., Weisman D.S., Heine W.F., Ciccone D.N., O'Neill T.B., Crick K.E., Pierce K.A., Lane W.S., Rathbun G., et al. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 405 (2000) 477-482
49. Yang X.J. Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays 26 (2004) 1076-1087
50. You Z., Chahwan C., Bailis J., Hunter T., and Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25 (2005) 5363-5379
51. Yu J., Palmer C., Alenghat T., Li Y., Kao G., and Lazar M.A. The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks. Cancer Res. 66 (2006) 9316-9322
52. Yuan S.S., Su J.H., Hou M.F., Yang F.W., Zhao S., and Lee E.Y. Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells. DNA Repair (Amst.) 1 (2002) 137-142
53. Zhang X., Wharton W., Yuan Z., Tsai S.C., Olashaw N., and Seto E. Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Mol. Cell. Biol. 24 (2004) 5106-5118
54. Zhao S., Weng Y.C., Yuan S.S., Lin Y.T., Hsu H.C., Lin S.C., Gerbino E., Song M.H., Zdzienicka M.Z., Gatti R.A., et al. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 405 (2000) 473-477
55. Zhao S., Renthal W., and Lee E.Y. Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic Acids Res. 30 (2002) 4815-4822