Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues

British Journal of Cancer

Volumn 86, Issue 6, 2002, Pages 917-923

  De Nigris, F ^a   Cerutti, J ^b   Morelli, C ^c   Califano, D ^a   Chiariotti, L ^d   Viglietto, G ^a,b   Fusco, A ^b,d  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d Univ degli Studi di Catanzaro   (Italy)

Author keywords

Expression; Neoplasias; SIR2; Telomerase; Thyroid

Indexed keywords

COMPLEMENTARY DNA; CYTOPLASM PROTEIN; PROTEIN SIR T8; REGULATOR PROTEIN; RNA; SILENT INFORMATION REGULATOR PROTEIN; SIRTUIN; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CHROMOSOME 17Q; CONTROLLED STUDY; DNA LIBRARY; DNA SEQUENCE; GENE ISOLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; MOLECULAR CLONING; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID ADENOMA; THYROID CARCINOMA; THYROID PAPILLARY CARCINOMA; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME MAPPING; GENE EXPRESSION; GENE LIBRARY; HISTONE DEACETYLASES; HUMANS; MOLECULAR SEQUENCE DATA; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TELOMERASE; THYROID NEOPLASMS; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0037128690     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600156     Document Type: Article

References (36)

1. The Sir2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
2. Thymosin β-10 gene overexpression correlates with the highly malignant neoplastic phenotype of transformed thyroid cells in vivo and in vitro
3. Blockage of c-MYC protein synthesis in human thyroid carcinoma cell lines reduces their growth in soft agar
4. The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasms
5. Increased expression of the negative growth factor, galactoside binding protein gene in transformed thyroid cells and in human thyroid carcinomas
6. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
7. Telomerase activity in human ovarian carcinoma
8. Long-term culture and functional characterization of follicular cells from adult normal human thyroids
9. Overexpression of the HIP gene coding for a Heparin/Heparan sulfate-binding protein in human thyroid carcinomas
10. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity
11. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
12. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
13. Human thyroid carcinogenesis
14. A new technique for the assay of infectivity of human adenovirus 5 DNA
15. Telomerase, cell immortality and cancer
16. The WHO histological classification of thyroid tumors a commentary on the second edition
17. Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss
18. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
19. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae
20. The SIR2/3/4 complex and SIR2 alone promote longevity, in Saccharomyces cerevisiae by two different mechanisms
21. Specific association of human telomerase activity with immortal cells and cancer
22. Pax8-PPARgamma1 fusion in oncogene human thyroid carcioma
23. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
24. Absence of cancer-associated changes in human fibroblast immortalized with telomerase
25. Evidence that a complex of SIR proteins interact with the silencer and telomere-binding protein RAP-1
26. Chromatin multiprotein complexes involved in the maintenance of transcription patterns
27. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
28. Molecular Cloning: A Laboratory Manual
29. A survey of telomerase activity in human cancer
30. The conserved core of human SIR homologue functions in yeast silencing
31. Telomere dynamics in human cancer cells
32. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
33. Enhanced expression of glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancer
34. Detection of myc translocation in lymphoma cells by fluorescence in situ hybridization with yeast artificial chromosomes
35. Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkB p65 protein expression
36. Leishmania major: Cell type dependent distribution of a 43 kDa antigen related to silent information regulatory-2 protein family