Medicine: Increase in activity during calorie restriction requires Sirt1

Science

Volumn 310, Issue 5754, 2005, Pages 1641-

  Chen, Danica ^a   Steele, Andrew D ^a,b   Lindquist, Susan ^b   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PROTEIN SIRT1; SILENT INFORMATION REGULATOR PROTEIN 2; SOMATOMEDIN C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; SIRT1 PROTEIN, MOUSE; SIRTUIN;

MEDICINE;

ANIMAL EXPERIMENT; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE; ANIMAL; EATING; GENETICS; MOTOR ACTIVITY; MOUSE MUTANT; MOVEMENT (PHYSIOLOGY); PHYSIOLOGY;

ANIMALIA;

ANIMALS; CALORIC RESTRICTION; EATING; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; MOVEMENT; SIRTUINS;

EID: 28844469898     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1118357     Document Type: Article

References (7)

1. S. J. Lin, P. A. Defossez, L Guarente, Science 289, 2126 (2000).
2. B. Rogina, S. L. Helfand, Proc. Natl. Acad. Sci. U.S.A. 101, 15998 (2004).
3. R. Weindruch, R. L. Walford, The Retardation of Aging and Disease by Dietary Restriction (Thomas, Springfield, IL, 1988).
4. J. L Weed, M. A. Lane, G. S. Roth, D. L. Speer, D. K. Ingram, Physiol. Behav. 62, 97 (1997).
5. R. J. McCarter et al., Aging (Milano) 9, 73 (1997).
6. J. O. Holloszy, K. B. Schechtman, J Appl. Physiol. 70, 1529 (1991).
7. L.G. is founder, consultant, stock holder, and board member of Elixir Pharmaceuticals, Inc., a company that develops therapeutics to treat age-related diseases. 5.L is founder, consultant, and stock holder for FoldRX Pharmaceuticals, Inc., a company that develops therapies for diseases of protein misfolding and amyloidosis. This work was supported by a Leukemia and Lymphoma Society postdoctoral fellowship to D.C. (5168-06) and NIH grant AC11119 to L.C.