ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Science

Volumn 316, Issue 5828, 2007, Pages 1160-1166

  Matsuoka, Shuhei ^a   Ballif, Bryan A ^b,e   Smogorzewska, Agata ^a,c   McDonald III, E Robert ^a   Hurov, Kristen E ^a   Luo, Ji ^a   Bakalarski, Corey E ^b   Zhao, Zhenming ^a   Solimini, Nicole ^a   Lerenthal, Yaniv ^d   Shiloh, Yosef ^d   Gygi, Steven P ^b   Elledge, Stephen J ^a  

^a LABORATORY FOR MOLECULAR MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Massachuttes General Hospital   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

^e UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE RAD3;

DNA; ENZYME ACTIVITY; GENETIC ANALYSIS; MAMMAL; PHYSIOLOGICAL RESPONSE; PROTEIN; SIGNAL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; COMPUTATIONAL BIOLOGY; CONSENSUS SEQUENCE; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; HUMANS; IMMUNOPRECIPITATION; ISOTOPE LABELING; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEOME; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; MAMMALIA;

EID: 34249947699     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140321     Document Type: Article

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33. We thank T. de Lange, A. D'Andrea, A. Carr, K. Nakanishi, M. Jasin, H. Takai, F. Graham, D. Zhang, D. Chou, B. Wang, M. Naylor, J.-M. Li, D. Lee, C. Zhou, and C. Cotta-Ramusino for reagents and advice; J. Qin for antibodies and sharing unpublished data; K. Matsuoka for helping with preparation of figures; and P. Park and Q. Xu for help with the bioinformatic analysis. A.S. is supported by T32CA09216 to the Pathology Department at the Massachusetts General Hospital. K.E.H. Is a Leukemia and Lymphoma Society Special Fellow. This work was supported by grants from NIH, including National Institute of Allergy and Infectious Diseases 1U19A1067751 (S.J.E.), and Department of Defense (S.J.E. and S.P.G.) and by the A-T (Ataxia-Telangiectasia) Medical Reseach Foundation, the A-T Children's Project, the Israel Science Foundation, the A-T Medical Research Trust, the Israel-Germany Joint Program on Cancer Reseach, the German Cancer Center DKFZ (Deutsches Krebsforschungszentrum), and the A-T Ease Foundation (Y.S.). S.J.E. is an investigator with the Howard Hughes Medical Institute.