Long-lived growth hormone receptor knockout mice: Interaction of reduced insulin-like growth factor I/insulin signaling and caloric restriction

Endocrinology

Volumn 146, Issue 2, 2005, Pages 851-860

  Al Regaiey, Khalid A ^a   Masternak, Michal M ^a   Bonkowski, Michael ^a   Sun, Liou ^a   Bartke, Andrzej ^a,b  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GROWTH HORMONE RECEPTOR; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; SIRTUIN; SIRTUIN 1; SOMATOMEDIN C; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY GROWTH; BODY WEIGHT; CALORIC RESTRICTION; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GLUCONEOGENESIS; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIFESPAN; LIPID METABOLISM; MALE; METABOLIC REGULATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ADENYLATE KINASE; ANIMALS; CALORIC RESTRICTION; CATTLE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTORS; GLUCONEOGENESIS; GLUCOSE; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; LIPID METABOLISM; LIVER; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, SOMATOTROPIN; SIGNAL TRANSDUCTION; SIRTUINS; SUPEROXIDE DISMUTASE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 12344335482     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1120     Document Type: Article

References (47)

1. Tatar M, Bartke A, Antebi A 2003 The endocrine regulation of aging by insulin-like signals. Science 299:1346-1351
2. Longo VD, Finch CE 2003 Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299:1342-1346
3. Weindruch R, Sohal RS 1997 Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med 337:986-994
4. Bartke A, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS 2001 Extending the lifespan of long-lived mice. Nature 414:412
5. Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H 2003 Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. FASEB J 17:1108-1109
6. Bartke A, Chandrashekar V, Bailey B, Zaczek D, Turyn D 2002 Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36:201-208
7. Miller RA, Chang Y, Galecki AT, Al-Regaiey K, Kopchick JJ, Bartke A 2002 Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Mol Endocrinol 16:2657-2666
8. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
9. Breese CR, Ingram RL, Sonntag WE 1991 Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-I), IGF-I gene expression, and IGF-I binding proteins. J Gerontol 46:B180-B187
10. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ 2000 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141:2608-2613
11. Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ 2003 Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144:3799-3810
12. Liu JL, Coschigano KT, Robertson K, Lipsett M, Guo Y, Kopchick JJ, Kumar U, Liu YL 2004 Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol 287:E405-E413
13. Da Silva Xavier G, Qian Q, Cullen PJ, Rutter GA 2004 Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic β-cell glucose sensing revealed by RNA silencing. Biochem J 377:149-158
14. Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D 2004 Inhibition of growth hormone action improves insulin sensitivity in liver IGF-I-deficient mice. J Clin Invest 113:96-105
15. Murakami S, Salmon A, Miller RA 2003 Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J 17:1565-1566
16. Bartke A, Heiman M, Turyn D, Dominici F, Kopchick JJ 2004 The role of growth hormone signaling in the control of aging. In: Strub RH, Mocchegiani E, eds. Neuroimmune biology. 1st ed. Amsterdam: Elsevier; vol 4:123-137
17. Boni-Schnetzler M, Hauri C, Zapf J 1999 Leptin is suppressed during infusion of recombinant human insulin-like growth factor I (rhIGF I) in normal rats. Diabetologia 42:160-166
18. Engstrom B, Burman P, Holdstock C, Karlsson FA 2003 Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 88:5193-5198
19. Chandran M, Phillips SA, Ciaraldi T, Henry RR 2003 Adiponectin: more than just another fat cell hormone? Diabetes Care 26:2442-2450
20. Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T 2004 Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 279:30817-30822
21. Combs TP, Wagner JA, Berger J, Doebber T, Wang W-J, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DS, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BG, Charron, MJ, Scherer PE, Moller DE 2002 Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: a potential mechanism of insulin sensitization. Endocrinology 143:998-1007
22. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y 2001 PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50:2094-2099
23. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Catling D, Kimura S, Nagai R, Kahn BB, Kadowaki T 2002 Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8:1288-1295
24. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE 2001 Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174
25. Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ 2002 Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51:2074-2081
26. Fryer LG, Parbu-Patel A, Carling D 2002 The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct pathways. J Biol Chem 277:25226-25232
27. Hardie DG 2003 Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144:5179-5183
28. Paradis S, Ruvkun G 1998 Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12:2488-2498
29. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I 2004 Akt negatively regulates the in vitro lifespan of human endothelial cells via a P53/p21-dependent pathway. EMBO J 23:212-220
30. Kaminker P 2004 Is Akt the mastermind behind age-related heart disease? Sci Aging Knowledge Environ 00:pe8
31. Barthel A, Schmoll D 2003 Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol 285:E685-E692
32. Tsuchiya T, Dhahbi JM, Cui X, Mote PL, Bartke A, Spindler SR 2004 Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics 17:307-315
33. Alregaiey KA, Hauck S, Bartke A, Effects of caloric restriction on antioxidant enzymes in long-lived GHR/BP-KO mice. Program of the 84th Annual Meeting of The Endocrine Society, San Francisco, CA, 2002, P-308
34. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM 2002 Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316-321
35. Puigserver P, Spiegelman BM 2003 Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78-90
36. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM 2001 Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138
37. Shaywitz AJ, Greenberg ME 1999 CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861
38. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M 2001 CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413:179-183
39. Zhou XY, Shibusawa N, Naik K, Porras D, Temple K, Ou H, Kaihara K, Roe MW, Brady MJ, Wondisford FE 2004 Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med 10:633-637
40. Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M 2003 CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ. Nature 426:190-193
41. Koubova J, Guarente L 2003 How does calorie restriction work? Genes Dev 17:313-321
42. Tissenbaum HA, Guarente L 2001 Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227-230
43. Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L 2004 Mammalian SIRT1 represses forkhead transcription factors. Cell 116:551-563
44. Brunei A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME 2004 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015
45. Daitoku H, Hatta M, Matsuzaki H, Aratani, S, Ohshima T, Miyagishi M, Nakajima T, Fukamizu A 2004 Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 101:10042-10047
46. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, De Cabo R, Sinclair DA 2004 Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392
47. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Oliveira RM, Leid M, McBurney MW, Guarente L 2004 Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 429:771-776