SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

Oncogene

Volumn 26, Issue 7, 2007, Pages 945-957

  Inoue, T ^a   Hiratsuka, M ^a   Osaki, M ^a,b   Yamada, H ^a   Kishimoto, I ^a   Yamaguchi, S ^a   Nakano, S ^a   Katoh, M ^a   Ito, H ^b   Oshimura, M ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Endoreduplication; Epigenetic modification; Mitotic checkpoint; SIRT2; Subcellular localization

Indexed keywords

CYCLIN B; CYTOPLASM PROTEIN; HISTONE; LEPTOMYCIN B; SILENT INFORMATION REGULATOR PROTEIN 2;

ARTICLE; CHROMOSOMAL INSTABILITY; CHROMOSOME CONDENSATION; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; DOWN REGULATION; DRUG ACCUMULATION; DRUG ACTIVITY; GLIOMA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; METAPHASE; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; CHROMOSOMES, HUMAN; GLIOMA; HISTONE DEACETYLASES; HUMANS; MITOSIS; NOCODAZOLE; PACLITAXEL; POLYPLOIDY; SIRTUINS; STRESS; TUBULIN; ULTRAVIOLET RAYS; X-RAYS;

EID: 33847053144     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209857     Document Type: Article

References (43)

1. Alonso M, Tamasdan C, Miller DC, Newcomb EW. (2003). Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. Mol Cancer Ther 2: 139-150.
2. Amon A. (1999). The spindle checkpoint. Curr Opin Genet Dev 9: 69-75.
3. Bae NS, Swanson MJ, Vassilev A, Howard BH. (2004). Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. J Biochem 135: 695-700.
4. Bertholon J, Wang Q, Falette N, Verny C, Auclair J, Chassot C et al. (2003). Chfr inactivation is not associated to chromosomal instability in colon cancers. Oncogene 22: 8956-8960.
5. Bigner SH, Vogelstein B. (1990). Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma. Brain Pathol 1: 12-18.
6. Brandes JC, van Engeland M, Wouters KA, Weijenberg MP, Herman JG. (2005). CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. Carcinogenesis 26: 1152-1156.
7. Chu YW, Wang R, Schmid I, Sakamoto KM. (1999). Analysis with flow cytometry of green fluorescent protein expression in leukemic cells. Cytometry 36: 333-339.
8. Cleveland DW, Mao Y, Sullivan KF. (2003). Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112: 407-421.
9. Cortez D, Elledge SJ. (2000). Conducting the mitotic symphony. Nature 406: 354-356.
10. Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. (1997). DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res 57: 1013-1019.
11. Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA. (2003). Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol 23: 3173-3185.
12. Finnin MS, Donigian JR, Pavletich NP. (2001). Structure of the histone deacetylase SIRT2. Nat Struct Biol 8: 621-625.
13. Hartwell LH, Kastan MB. (1994). Cell cycle control and cancer. Science 266: 1821-1828.
14. Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H et al. (2003). Proteomics-based identification of differentially expressed genes in human gliomas: downregulation of SIRT2 gene. Biochem Biophys Res Commun 309: 558-566.
15. Honda T, Tamura G, Waki T, Kawata S, Nishizuka S, Motoyama T. (2004). Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia. Br J Cancer 90: 2013-2016.
16. Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A et al. (2002). HDAC6 is a microtubule-associated deacetylase. Nature 417: 455-458.
17. Imai Y, Shiratori Y, Kato N, Inoue T, Omata M. (1999). Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. Jpn J Cancer Res 90: 837-840.
18. Kang D, Chen J, Wong J, Fang G. (2002). The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J Cell Biol 156: 249-259.
19. Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B et al. (1999). Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci USA 96: 9112-9117.
20. Kyrylenko S, Kyrylenko O, Suuronen T, Salminen A. (2003). Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases. Cell Mol Life Sci 60: 1990-1997.
21. la Cour T, Gupta R, Rapacki K, Skriver K, Poulsen FM, Brunak S. (2003). NESbase version 1.0: a database of nuclear export signals. Nucleic Acids Res 31: 393-396.
22. la Cour T, Kiemer L, Molgaard A, Gupta R, Skriver K, Brunak S. (2004). Analysis and prediction of leucine-rich nuclear export signals. Protein Eng Des Sel 17: 527-536.
23. Lengauer C, Kinzler KW, Vogelstein B. (1998). Genetic instabilities in human cancers. Nature 396: 643-649.
24. Mattaj IW, Englmeier L. (1998). Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 67: 265-306.
25. Mizuno K, Osada H, Konishi H, Tatematsu Y, Yatabe Y, Mitsudomi T et al. (2002). Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Oncogene 21: 2328-2333.
26. Muhua L, Adames NR, Murphy MD, Shields CR, Cooper JA. (1998). A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Nature 393: 487-491.
27. Musacchio A, Hardwick KG. (2002). The spindle checkpoint: structural insights into dynamic signaling. Nat Rev Mol Cell Biol 3: 731-741.
28. Nitta M, Tsuiki H, Arima Y, Harada K, Nishizaki T, Sasaki K et al. (2002). Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability. Genes Cells 7: 151-162.
29. Nishigaki R, Osaki M, Hiratsuka M, Toda T, Murakami K, Jeang KT et al. (2005). Proteomic identification of differentially-expressed genes in human gastric carcinomas. Proteomics 5: 3205-3213.
30. North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. (2003). The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell 11: 437-444.
31. Paulovich AG, Toczyski DP, Hartwell LH. (1997). When checkpoints fail. Cell 88: 315-321.
32. Piperno G, LeDizet M, Chang XJ. (1987). Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J Cell Biol 104: 289-302.
33. Qian K, Chen H, Wei Y, Hu J, Zhu G. (2005). Differentiation of endometrial stromal cells in vitro: down-regulation of suppression of the cell cycle inhibitor p57 by HOXA10? Mol Hum Reprod 11: 245-251.
34. Roberts EC, Deed RW, Inoue T, Norton JD, Sharrocks AD. (2001). Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. Mol Cell Biol 21: 524-533.
35. Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S et al. (2005). Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 24: 4531-4539.
36. Scolnick DM, Halazonetis TD. (2000). Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406: 430-435.
37. Serrador JM, Cabrero JR, Sancho D, Mittelbrunn M, Urzainqui A. (2004). HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization. Immunity 20: 417-428.
38. Shackney SE, Smith CA, Miller BW, Burholt DR, Murtha K, Giles HR et al. (1989). Model for the genetic evolution of human solid tumors. Cancer Res 49: 3344-3354.
39. Takahashi T, Shivapurkar N, Riquelme E, Shigematsu H, Reddy J, Suzuki M et al. (2004). Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. Clin Cancer Res 10: 6126-6133.
40. Takai N, Hamanaka R, Yoshimatsu J, Miyakawa I. (2005). Polo-like kinases (Plks)and cancer. Oncogene 24: 287-291.
41. Tsuiki H, Nitta M, Tada M, Inagaki M, Ushio Y, Saya H. (2001). Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines. Oncogene 20: 420-429.
42. Xie S, Xie B, Lee MY, Dai W. (2005). Regulation of cell cycle checkpoints by polo-like kinases. Oncogene 24: 277-286.
43. Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ et al. (2005). Chfr is required for tumor suppression and Aurora A regulation. Nat Genet 37: 401-406.