Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

Molecular Cell

Volumn 16, Issue 1, 2004, Pages 93-105

  Vaquero, Alejandro ^a   Scher, Michael ^a   Lee, Donghoon ^a   Erdjument Bromage, Hediye ^b   Tempst, Paul ^b   Reinberg, Danny ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE H1; HISTONE H4; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; POLYPEPTIDE; PROTEIN; RNA; SIRT1 PROTEIN; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CHROMATIN; CONTROLLED STUDY; DEACETYLATION; DNA BINDING; GENE SILENCING; HETEROCHROMATIN; HUMAN; HUMAN CELL; METHYLATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; YEAST;

ACETYLATION; CELL NUCLEUS; GENE EXPRESSION REGULATION; HETEROCHROMATIN; HISTONE DEACETYLASES; HISTONES; HUMANS; NAD; PROMOTER REGIONS (GENETICS); SIRTUINS;

SACCHAROMYCETALES;

EID: 4944245398     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.08.031     Document Type: Article

References (73)

1. Albig W., Runge D.M., Kratzmeier M., Doenecke D. Heterologous expression of human H1 histones in yeast. FEBS Lett. 435:1998;245-250
2. Bereshchenko O.R., Gu W., Dalla-Favera R. Acetylation inactivates the transcriptional repressor BCL6. Nat. Genet. 32:2002;606-613
3. Berger S.L. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12:2002;142-148
4. Brachmann C.B., Sherman J.M., Devine S.E., Cameron E.E., Pillus L., Boeke J.D. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9:1995;2888-2902
5. Braunstein M., Rose A.B., Holmes S.G., Allis C.D., Broach J.R. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7:1993;592-604
6. Braunstein M., Sobel R.E., Allis C.D., Turner B.M., Broach J.R. Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol. Cell. Biol. 16:1996;4349-4356
7. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 303:2004;2011-2015
8. Carruthers L.M., Bednar J., Woodcock C.L., Hansen J.C. Linker histones stabilize the intrinsic salt-dependent folding of nucleosomal arrays. mechanistic ramifications for higher-order chromatin folding Biochemistry. 37:1998;14776-14787
9. Derbyshire M.K., Weinstock K.G., Strathern J.N. HST1, a new member of the SIR2 family of genes. Yeast. 12:1996;631-640
10. Dignam J.D., Martin P.L., Shastry B.S., Roeder R.G. Eukaryotic gene transcription with purified components. Methods Enzymol. 101:1983;582-598
11. D'Incalci M., Allavena P., Wu R.S., Bonner W.M. H1 variant synthesis in proliferating and quiescent human cells. Eur. J. Biochem. 154:1986;273-279
12. Fan Y., Nikitina T., Morin-Kensicki E.M., Zhao J., Magnuson T.R., Woodcock C.L., Skoultchi A.I. H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo. Mol. Cell. Biol. 23:2003;4559-4572
13. Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273:2000;793-798
14. Fulco M., Schiltz R.L., Iezzi S., King M.T., Zhao P., Kashiwaya Y., Hoffman E., Veech R.L., Sartorelli V. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell. 12:2003;51-62
15. Gartenberg M.R. The Sir proteins of Saccharomyces cerevisiae. mediators of transcriptional silencing and much more Curr. Opin. Microbiol. 3:2000;132-137
16. Gray S.G., Ekstrom T.J. The human histone deacetylase family. Exp. Cell Res. 262:2001;75-83
17. Gurley L.R., Valdez J.G., Buchanan J.S. Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase. J. Biol. Chem. 270:1995;27653-27660
18. Hansen J.C. Conformational dynamics of the chromatin fiber in solution. determinants, mechanisms, and functions Annu. Rev. Biophys. Biomol. Struct. 31:2002;361-392
19. Hasty P. The impact energy metabolism and genome maintenance have on longevity and senescence. lessons from yeast to mammals Mech. Ageing Dev. 122:2001;1651-1662
20. Higurashi M., Adachi H., Ohba Y. Synthesis and degradation of H1 histone subtypes in mouse lymphoma L5178Y cells. J. Biol. Chem. 262:1987;13075-13080
21. Hong L., Schroth G.P., Matthews H.R., Yau P., Bradbury E.M. Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA. J. Biol. Chem. 268:1993;305-314
22. Imai S., Armstrong C.M., Kaeberlein M., Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403:2000;795-800
23. Jedrusik M.A., Schulze E. A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans. Development. 128:2001;1069-1080
24. Jedrusik M.A., Schulze E. Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing. Mol. Cell. Biol. 23:2003;3681-3691
25. Jeppesen P., Turner B.M. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell. 74:1993;281-289
26. Johnson C.A., O'Neill L.P., Mitchell A., Turner B.M. Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome. Nucleic Acids Res. 26:1998;994-1001
27. Kuzmichev A., Nishioka K., Erdjument-Bromage H., Tempst P., Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16:2002;2893-2905
28. Lacoste N., Utley R.T., Hunter J.M., Poirier G.G., Cote J. Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J. Biol. Chem. 277:2002;30421-30424
29. Landry J., Sutton A., Tafrov S.T., Heller R.C., Stebbins J., Pillus L., Sternglanz R. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA. 97:2000;5807-5811
30. Lee H., Habas R., Abate-Shen C. MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science. 304:2004;1675-1678
31. Lennox R.W., Cohen L.H. The histone H1 complements of dividing and nondividing cells of the mouse. J. Biol. Chem. 258:1983;262-268
32. Lennox R.W., Cohen L.H. Analysis of histone subtypes and their modified forms by polyacrylamide gel electrophoresis. Methods Enzymol. 170:1989;532-549
33. Lindner H., Sarg B., Grunicke H., Helliger W. Age-dependent deamidation of H1(0) histones in chromatin of mammalian tissues. J. Cancer Res. Clin. Oncol. 125:1999;182-186
34. Loyola A., LeRoy G., Wang Y.H., Reinberg D. Reconstitution of recombinant chromatin establishes a requirement for histone-tail modifications during chromatin assembly and transcription. Genes Dev. 15:2001;2837-2851
35. Luger K., Mader A.W., Richmond R.K., Sargent D.F., Richmond T.J. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature. 389:1997;251-260
36. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107:2001;137-148
37. McCord R., Pierce M., Xie J., Wonkatal S., Mickel C., Vershon A.K. Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes. Mol. Cell. Biol. 23:2003;2009-2016
38. Morales V., Giamarchi C., Chailleux C., Moro F., Marsaud V., Le Ricousse S., Richard-Foy H. Chromatin structure and dynamics. functional implications Biochimie. 83:2001;1029-1039
39. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell. 116:2004;551-563
40. Muth V., Nadaud S., Grummt I., Voit R. Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 20:2001;1353-1362
41. Newman B.L., Lundblad J.R., Chen Y., Smolik S.M. A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Genetics. 162:2002;1675-1685
42. Ng H.H., Feng Q., Wang H., Erdjument-Bromage H., Tempst P., Zhang Y., Struhl K. Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 16:2002;1518-1527
43. Ng H.H., Ciccone D.N., Morshead K.B., Oettinger M.A., Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells. a potential mechanism for position-effect variegation Proc. Natl. Acad. Sci. USA. 100:2003;1820-1825
44. Nishioka K., Rice J.C., Sarma K., Erdjument-Bromage H., Werner J., Wang Y., Chuikov S., Valenzuela P., Tempst P., Steward R., et al. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell. 9:2002;1201-1213
45. Parseghian M.H., Newcomb R.L., Winokur S.T., Hamkalo B.A. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin. distribution in human fetal fibroblasts Chromosome Res. 8:2000;405-424
46. Parseghian M.H., Newcomb R.L., Hamkalo B.A. Distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin II. distribution in human adult fibroblasts J. Cell. Biochem. 83:2001;643-659
47. Peters A.H., Mermoud J.E., O'Carroll D., Pagani M., Schweizer D., Brockdorff N., Jenuwein T. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat. Genet. 30:2002;77-80
48. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Oliveira R.M., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429:2004;771-776
49. Rea S., Eisenhaber F., O'Carroll D., Strahl B.D., Sun Z.W., Schmid M., Opravil S., Mechtler K., Ponting C.P., Allis C.D., et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature. 406:2000;593-599
50. Rice J.C., Nishioka K., Sarma K., Steward R., Reinberg D., Allis C.D. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev. 16:2002;2225-2230
51. Rosenberg M.I., Parkhurst S.M. Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell. 109:2002;447-458
52. Santos-Rosa H., Schneider R., Bannister A.J., Sherriff J., Bernstein B.E., Emre N.C., Schreiber S.L., Mellor J., Kouzarides T. Active genes are tri-methylated at K4 of histone H3. Nature. 419:2002;407-411
53. Sarg B., Helliger W., Hoertnagl B., Puschendorf B., Lindner H. The N-terminally acetylated form of mammalian histone H1(o), but not that of avian histone H5, increases with age. Arch. Biochem. Biophys. 372:1999;333-339
54. Sarma K., Nishioka K., Reinberg D. Tips in analyzing antibodies directed against specific histone tail modifications. Methods Enzymol. 376:2004;255-269
55. Schneider R., Bannister A.J., Myers F.A., Thorne A.W., Crane-Robinson C., Kouzarides T. Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat. Cell Biol. 6:2004;73-77
56. Senawong T., Peterson V.J., Avram D., Shepherd D.M., Frye R.A., Minucci S., Leid M. Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J. Biol. Chem. 278:2003;43041-43050
57. Shankaranarayana G.D., Motamedi M.R., Moazed D., Grewal S.I. Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr. Biol. 13:2003;1240-1246
58. Shiio Y., Eisenman R.N. Histone sumoylation is associated with transcriptional repression. Proc. Natl. Acad. Sci. USA. 100:2003;13225-13230
59. Suka N., Suka Y., Carmen A.A., Wu J., Grunstein M. Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol. Cell. 8:2001;473-479
60. Suka N., Luo K., Grunstein M. Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat. Genet. 32:2002;378-383
61. Sutton A., Heller R.C., Landry J., Choy J.S., Sirko A., Sternglanz R. A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol. Cell. Biol. 21:2001;3514-3522
62. Takata T., Ishikawa F. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 301:2003;250-257
63. Tanny J.C., Moazed D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2. evidence for acetyl transfer from substrate to an NAD breakdown product Proc. Natl. Acad. Sci. USA. 98:2001;415-420
64. Tissenbaum H.A., Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 410:2001;227-230
65. Turner B.M., Birley A.J., Lavender J. Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei. Cell. 69:1992;375-384
66. van Leeuwen F., Gafken P.R., Gottschling D.E. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell. 109:2002;745-756
67. Vaquero A., Loyola A., Reinberg D. The constantly changing face of chromatin. Sci. Aging Knowledge Environ. 14:2003;RE4
68. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:2001;149-159
69. Wolffe A. Chromatin. Structure and Function:1998;Academic Press, San Diego, CA
70. Workman J.L., Kingston R.E. Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu. Rev. Biochem. 67:1998;545-579
71. Xie J., Pierce M., Gailus-Durner V., Wagner M., Winter E., Vershon A.K. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J. 18:1999;6448-6454
72. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23:2004;2369-2380
73. Zhao K., Chai X., Clements A., Marmorstein R. Structure and autoregulation of the yeast Hst2 homolog of Sir2. Nat. Struct. Biol. 10:2003;864-871