Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Cell

Volumn 108, Issue 6, 2002, Pages 781-794

  Ma, Yunmei ^a   Pannicke, Ulrich ^b   Schwarz, Klaus ^b   Lieber, Michael R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; EXONUCLEASE; PHOSPHODIESTERASE I; PROTEIN; PROTEIN ARTEMIS; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STABILITY; REGULATORY MECHANISM;

EID: 0037155703     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00671-2     Document Type: Article

References (65)

1. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
2. The DNA-activated protein kinase-DNA-PK
3. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic tissues
4. Hairpin coding end opening is mediated by RAG1 and RAG2 proteins
5. Effects of base sequence on the loop folding in DNA hairpins
6. The SCID mouse mutant: Definition, characterization, and potential uses
7. Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase
8. Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C
9. The RAG proteins and V(D)J recombination: Complexes, ends, and transposition
10. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
11. Mechanistic constraints on diversity in human V(D)J recombination
12. Recent advances in understanding V(D)J recombination
13. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
14. Antigen receptor gene rearrangement
15. DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes
16. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
17. Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome
18. Analysis of the defect in DNA end joining in the murine scid mutation
19. A link between double-strand break-related repair and V(D)J recombination: The scid mutation
20. Isolation and characterization of pso mutants sensitive to photo-addition of psoralen derivatives in Saccharomyces cerevisiae
21. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
22. Hairpin formation in the self-complementary dodecamer d-GGTACGCGTACC and derivatives containing GA and IA mispairs
23. Homologous pairing and DNA strand-exchange proteins
24. Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
25. The mechanism of V(D)J joining: Lessons from molecular, immunological and comparative analyses
26. Site-specific recombination in the immune system
27. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination, and repair
28. Pathological and physiological double-strand breaks: Roles in cancer, aging, and the immune system
29. The biochemistry and biological significance of nonhomologous DNA end joining: An essential repair process in multicellular eukaryotes
30. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
31. The mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
32. DNA length-dependent cooperative interaction in the binding of Ku to DNA
33. cs
34. Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments
35. DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
36. A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p
37. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
38. A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency
39. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
40. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
41. Conformational feasibility of a hairpin with two purines in the loop. 5′-d-GGTACIAGTACC-3′
42. V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
43. A newly identified DNA ligase of Sacchromyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks
44. Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination
45. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
46. H locus
47. RAG mutations in human B cell-negative SCID
48. Essential amino acids for substrate binding and catalysis of human flap endonuclease 1
49. Identification of Saccharomyces cerevisiae DNA ligase IV: Involvement in DNA double-strand break repair
50. Regulated genomic instability and neoplasia in the lymphoid lineage
51. Similarities between initiation of V(D)J recombination and retroviral integration
52. Chromosomal stability and the DNA double-stranded break connection
53. V(D)J recombination defects in lymphocytes due to RAG mutations: Severe immunodeficiency with a spectrum of clinical presentations
54. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
55. Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini
56. Arabidopsis DNA ligase IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double-strand break repair protein XRCC4
57. Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway
58. Yeast DNA ligase IV mediates non-homologous DNA end joining
59. Human DNA repair genes
60. A role for FEN-1 in nonhomologous DNA end joining: The order of strand annealing and nucleolytic processing events
61. Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage
62. Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
63. V(D)J rearrangement in Nijmegen breakage syndrome
64. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates