Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction

Science

Volumn 309, Issue 5742, 2005, Pages 1861-1864

  Lamming, Dudley W ^a   Latorre Esteves, Magda ^a   Medvedik, Oliver ^a   Wong, Stacy N ^b   Tsang, Felicia A ^b   Wang, Chen ^b   Lin, Su Ju ^b   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; MAINTENANCE; MICROORGANISMS; STABILITY; YEAST;

CALORIE RESTRICTION (CR); DECETYLASE; HOMOLOG; LIFE SPAN;

BIOLOGY;

HISTONE DEACETYLASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBOSOME DNA; FUNGAL DNA; HST1 PROTEIN, S CEREVISIAE; HST2 PROTEIN, S CEREVISIAE; NICOTINAMIDE; SACCHAROMYCES CEREVISIAE PROTEIN; SILENT INFORMATION REGULATOR PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRTUIN;

CYTOLOGY;

ARTICLE; CALORIC RESTRICTION; DIET; GENE; GENOMIC INSTABILITY; HST2 GENE; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; SIR2 GENE; YEAST; FUNGAL GENE; GENE DELETION; GENE SILENCING; GENETIC RECOMBINATION; GENETICS; LONGEVITY; MUTATION; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE;

RODENTIA;

CALORIC RESTRICTION; DNA, FUNGAL; DNA, RIBOSOMAL; GENE DELETION; GENE SILENCING; GENES, FUNGAL; HISTONE DEACETYLASES; LONGEVITY; MUTATION; NIACINAMIDE; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS;

EID: 24944559665     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113611     Document Type: Article

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33. We thank members of the Lin and Sinclair labs for valuable insights and J. Wood for critical reading of the manuscript This work was supported by the National Institute of General Medical Sciences, the National Institute on Aging, the Harvard-Armenise Foundation, and The Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard. 5.-J.L. and D.A.S. are Ettison Medical Research Foundation New Research Scholars. D.W.L. is supported by a National Eye Institute training grant. D.A.S. is a cofounder and board member of, and has equity in, Sirtris Pharmaceuticals, a company whose goal is to discover sirtuin-modulating drugs.