Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

Nature

Volumn 421, Issue 6923, 2003, Pages 643-648

  Wong, Kwok Kin ^a   Maser, Richard S ^a,b   Bachoo, Robert M ^a,c   Menon, Jayant ^f   Carrasco, Daniel R ^a,d   Gu, Yansong ^g   Alt, Frederick W ^b,e   DePinho, Ronald A ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING OF MATERIALS; BIOLOGICAL ORGANS; ENZYMES; MUTAGENESIS; NEUROLOGY; PATHOLOGY; RNA; TISSUE;

NEOPLASIA;

CELLS;

ATM PROTEIN;

MEDICINE;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA TELANGIECTASIA; CARCINOGENESIS; CAUSE OF DEATH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; GENE MUTATION; GENETIC STABILITY; HOMEOSTASIS; IN VIVO STUDY; MOUSE; NERVE DEGENERATION; NONHUMAN; NULL ALLELE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; STEM CELL; T CELL LYMPHOMA; TELOMERE;

AGING; ALOPECIA; ANAPHASE; ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; DNA-BINDING PROTEINS; FIBROBLASTS; HAIR COLOR; HOMEOSTASIS; LYMPHOMA, T-CELL; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; RNA; STEM CELLS; SURVIVAL RATE; TELOMERASE; TELOMERE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; WOUND HEALING;

ANIMALIA; ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0037421896     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01385     Document Type: Article

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