Genome maintenance mechanisms for preventing cancer

Nature

Volumn 411, Issue 6835, 2001, Pages 366-374

  Hoeijmakers, Jan H J ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; DNA; MUTAGENESIS; ONCOLOGY; TUMORS;

CELL GROWTH;

GENES;

DNA; NUCLEOTIDE;

CANCER; CANCER GENETICS; CANCER PREVENTION; CARCINOGENESIS; CELL GROWTH; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENE MUTATION; GENOME; HUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BASE PAIR MISMATCH; DNA DAMAGE; DNA REPAIR; GENOME; HUMANS; MODELS, GENETIC; NEOPLASMS; RECOMBINATION, GENETIC; SYNDROME; TELOMERE; TRANSCRIPTION, GENETIC;

EID: 0035902108     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35077232     Document Type: Review

References (67)

1. Loeb, L. A. Mutator phenotype maybe required for multistage carcinogenesis. Cancer Res. 51, 3075-3079 (1991).
2. Cadet, J., Berger, M., Douki, T. & Ravanat, J. L. Oxidative damage to DNA: formation, measurement, and biological significance. Rev. Physiol. Biochem. Pharmacol. 131, 1-87 (1997).
3. Finkel, T. & Holbrook, N. J. Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247 (2000).
4. Lindahl, T. Instability and decay of the primary structure of DNA. Nature 362, 709-715 (1993).
5. Yamaizumi, M. & Sugano, T. UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9, 2775-2784 (1994).
6. Goodman, M. R. & Tippin, B. Sloppier copier DNA polymerases involved in genome repair. Curr. Opin. Genet. Dev. 10, 162-168 (2000).
7. Kunkel, T. A. & Bebenck, K. DNA replicalion fidelity. Annu. Rev. Biochem. 69, 497-529 (2000).
8. Lawrence, C. The Rad6 DNA repair pathway in Saccharomyces cerevisiae: what does it do and how does it do it? BioEssays 16, 253-258 (1994).
9. Masutani, C. et al. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η. Nature 399, 700-704 (1999).
10. Johnson, R. E., Kondralick, C. M., Prakash S. & Prakash, L. hRAD30 mutations in the variant form of xeroderma pigmentosum. Science 285, 263-265 (1999).
11. Zhou, B. B. & Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
12. Friedberg, E. C., Walker, G. C. & Siede, W. DNA Repair and Mutagenesis (ASM Press, Washington DC, 1995).
13. Lindahl, T. & Wood, R. D. Quality control by DNA repair. Science 286, 1897-1905 (1999).
14. Takata, M. et al. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17, 5497-5508 (1998).
15. Tornaletti, S. & Hanawalt, P. C. Effect of DNA lesions on transcription elongation. Biochimie 81, 139-148 (1999).
16. de Laat, W. L., Jaspers, N. G. & Hoeijmakers, J. H. Molecular mechanism of nucleotide excision repair. Genes Dev. 13, 768-785 (1999).
17. Batty, D. P. & Wood, R. D. Damage recognition in nucleotide excision repair of DNA. Gene 241, 193-204 (2000).
18. Bootsma, D., Kraemer, K. H., Cleaver, J. & Hoeijmakers, J. H. J. in The Metabolic and Molecular Basis of Inherited Disease Vol. 1 (eds Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D.) 677-703 (McGraw-Hill, New York, 2001).
19. Lehmann, A. R. The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases. Genes Dev. 15, 15-23 (2001).
20. Vermeulen, W. et al. A temperature-sensitive disorder in basal transcription and DNA repair in humans. Nature Genet. 27, 299-303 (2001).
21. de Boer, J. & Hoeijmakers, J. H. Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair. Biochimie 81, 127-137 (1999).
22. Wyatt, M. D., Allan, J. M., Lau, A. Y., Ellenberger, T. F. & Samson, L. D. 3-methyladenine DNA glycosylases: structure, function, and biological importance. BioEssays 21, 668-676 (1999).
23. Mol, C. D., Parikh, S. S., Putnam, C. D., Lo, T. P. & Tainer, J. A. DNA repair mechanisms for the recognition and removal of damaged DNA bases. Annu. Rev. Biophys. Biomol. Struct. 28, 101-128 (1999).
24. Bruner, S. D., Norman, D. P. & Verdine, G. L. Structural basis for recognition and repair of the endogenous mutagen 8 oxoguanine in DNA. Nature 403, 859-866 (2000)
25. Wilson, D. M. & Thompson, L. H. Life without DNA repair. Proc. Natl Acad. Sci. USA 94, 12754-12757 (1997).
26. Divine, K. K et al. The XRCCl 399 glutamine allele is a risk factor for adenocarcinoma of the lung. Mutat. Res. 461, 273-278 (2001).
27. Khanna, K. K. & Jackson, S. P. DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genet. 27, 247-254 (2001).
28. Rotman, G. & Shiloh, Y. ATM: from gene to function. Hum. Mol. Genet. 7, 1555-1563 (1998).
29. Paull, T. T. et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-8895 (2000).
30. Petrini, J. H. The Mrell complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12, 293-296 (2000)
31. Digweed, M., Reis, A. & Sperling, K. Nijmegen breakage syndrome: consequences of defective DNA double strand break repair. BioEssays 21, 649-655 (1999).
32. Riballo, E. et al. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr. Biol. 9, 699-702 (1999).
33. Van Gent, D. C., Hoeijmakers, J. H. J. & Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nature Rev. Genet. 2, 196-206 (2001).
34. Gurley, K. E. & Kemp, C. J. Synthetic lethality between mutation in Atm and DNA-PKcs during murine embryogenesis. Curr. Biol. 11, 191-194 (2001).
35. Jasin, M. Chromosome breaks and genomic instability. Cancer Invest. 18, 78-86 (2000).
36. Scully, R. & Livingston, D. M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432 (2000).
37. Moynahan, M. E., Pierce, A. J. & Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263-272 (2001).
38. Gao, Y. et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404, 897-900 (2000).
39. Jiricny, J. Replication errors: challenging the genome. EMBO J. 17, 6427-6436 (1998).
40. Jiricny, J. & Nystrom-Lahti, M. Mismatch repair defects in cancer. Curr. Opin. Genet. Dev. 10, 157-161 (2000).
41. Heyer, J., Yang, K., Lipkin, M., Edelmann, W. & Kucherlapati, R. Mouse models for colorectal cancer. Oncogene 18, 5325-5333 (1999).
42. McEacherii, M. J., Krauskopf, A. & Blackburn, F. H. Telomeres and their control. Annu. Rev. Genet. 34, 331-358 (2000).
43. Shay, J. W. & Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer 33, 787-791 (1997).
44. Counter, C. M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929 (1992).
45. Greider, C. W. Telomerase activity, cell proliferation, and cancer. Proc. Natl Acad. Sci. USA 95, 90-92 (1998).
46. Tang, R., Cheng, A. J., Wang, J. Y. & Wang, T. C. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis. Cancer Res. 58, 4052-4054 (1998).
47. Gonzalez-Suarez, F., Samper, E., Flores, J. M. & Blasco, M. A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nature Genet. 26, 114-117 (2000).
48. DePinho, R. A. The age of cancer. Nature 408, 248-254 (2000).
49. de Lange, T. & Jacks, T. For better or worse? Telomerase inhibition and cancer, Cell 98, 273-275 (1999).
50. Bryan, T. M., Englezou, A., Dalla-Pozza, L., Dunham, M. A. & Reddel, R. R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nature Med. 3, 1271-1274 (1997).
51. Rudolph, K. L. et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96, 701-712 (1999).
52. Jones, P. A. & Lainl, P. W. Cancer epigenetics comes of age. Nature Genet. 21, 163-167 (1999).
53. Sugasawa, K. et al. A multistep damage recognition mechanism for global genomic nucleolide excision repair. Genes Dev. 15, 507-521 (2001).
54. Tang, J. Y., Hwang, B. J., Ford, J. M., Hanawalt, P. C. & Chu, G. Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. Mol. Cell 5, 737-744 (2000).
55. Le Page, E. et al. Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TPIIH, and CSB and implications for Cockayne syndrome. Cell 101, 159-171 (2000).
56. Buschta-Hedayat, N., Buterin, T., Hess, M. T., Missura, M. & Naegeli, H. Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA. Proc. Natl Acad. Sci. USA 96, 6090-6095 (1999).
57. Sugasawa, K. et al. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell 2, 223-232 (1998).
58. Houtsmuller, A. B. et al. Action of DNA repair endonuclease ERCCl/XPF in living cells. Science 284, 958-961 (1999).
59. Whitehouse, C. J. et al. XRCCl stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell 104, 107-117 (2001).
60. Haber, J. E. Partners and pathways repairing a double-strand break. Trends Genet 16, 259-264 (2000).
61. Davies, A. A. et al. Role of BRCA2 in control of RAD51 recombination and DNA repair protein. Mol. Cell 7, 273-282 (2001).
62. Hsu, H. L. et al. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 14, 2807-2812 (2000).
63. Kolodner, R. D., & Marsischky, G. T. Eukaryotic DNA mismatch repair. Curr. Opin. Genet. Dev. 9, 89-96 (1999).
64. Harfe, B. D. & Jinks-Robertson, S. DNA mismatch repair and genetic instability. Annu. Rev. Genet 34, 359-399 (2000).
65. Obmolova, G., Ban, C., Hsieh, P. & Yang, W. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature 407, 703-710 (2000).
66. Lamets, M. H. et al. The crystal structure of DNA mismatch repair proten MutS binding to a G-T mismatch. Nature 407, 711-717 (2000).
67. Karran, P. & Bignami, M. DNA damage tolerance, mismatch repair and genome instability. BioEssays 16, 833-839 (1994).