Hormonal control of androgen receptor function through SIRT1

Molecular and Cellular Biology

Volumn 26, Issue 21, 2006, Pages 8122-8135

  Fu, Maofu ^a   Liu, Manran ^a   Sauve, Anthony A ^b   Jiao, Xuanmao ^a   Zhang, Xueping ^a   Wu, Xiaofang ^a   Powell, Michael J ^a   Yang, Tianle ^b   Gu, Wei ^c   Avantaggiati, Maria Laura ^d   Pattabiraman, Nagarajan ^d   Pestell, Timothy G ^a   Wang, Fang ^e   Quong, Andrew A ^a   Wang, Chenguang ^a   Pestell, Richard G ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Columbia University ^*  (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; CELL NUCLEUS RECEPTOR; HISTONE DEACETYLASE; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN; SIRTUIN 1; UNCLASSIFIED DRUG;

AGING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL CONTACT; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; DEACETYLATION; EMBRYO; GENE SILENCING; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; DIHYDROTESTOSTERONE; GENE EXPRESSION REGULATION; GENES, REPORTER; HISTONE ACETYLTRANSFERASES; HUMANS; LYSINE; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; SIRTUINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 33750367457     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00289-06     Document Type: Article

References (59)

1. Altenberg, B., and K. O. Greulich. 2004. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 84:1014-1020.
2. Anderson, R. M., K. J. Bitterman, J. G. Wood, O. Medvedik, and D. A. Sinclair. 2003. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423:181-185.
3. Avalos, J. L., I. Celic, S. Muhammad, M. S. Cosgrove, J. D. Boeke, and C. Wolberger. 2002. Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol. Cell 10:523-535.
4. Barlev, N. A., L. Liu, N. H. Chehab, K. Mansfield, K. G. Harris, T. D. Halazonetis, and S. L. Berger. 2001. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 8:1243-1254.
5. Baron, A., T. Migita, D. Tang, and M. Loda. 2004. Fatty acid synthase: a metabolic oncogene in prostate cancer? J. Cell Biochem. 91:47-53.
6. Berman, H. M., T. Battistuz, T. N. Bhat, W. F. Bluhm, P. E. Bourne, K. Burkhardt, Z. Feng, G. L. Gilliland, L. Iype, S. Jain, P. Fagan, J. Marvin, D. Padilla, V. Ravichandran, B. Schneider, N. Thanki, H. Weissig, J. D. Westbrook, and C. Zardecki. 2002. The Protein Data Bank. Acta Crystallogr. D 58:899-907.
7. Bevan, C. L., S. Hoare, F. Claessens, D. M. Heery, and M. G. Parker. 1999. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol. Cell. Biol. 19:8383-8392.
8. Blander, G., and L. Guarente. 2004. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73:417-435.
9. Bouras, T., M. Fu, A. A. Sauve, F. Wang, A. A. Quong, N. D. Perkins, R. T. Hay, W. Gu, and R. G. Pestell. 2005. SIRT1 deacetylation and repression of P300 involves lysine residues 1020/1024 within the cell-cycle regulatory domain 1. J. Biol. Chem. 280:10264-10276.
10. Brunet, A., L. B. Sweeney, J. F. Sturgill, K. F. Chua, P. L. Greer, Y. Lin, H. Tran, S. E. Ross, R. Mostoslavsky, H. Y. Cohen, L. S. Hu, H. L. Cheng, M. P. Jedrychowski, S. P. Gygi, D. A. Sinclair, F. W. Alt, and M. E. Greenberg. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.
11. Catlin, D. 1995. Anabolic steroids, p. 2362-2369. In L. J. De Groot (ed.), Endocrinology, 3rd ed. W. B. Saunders and Co., Philadelphia, Pa.
12. Chen, C. D., D. S. Welsbie, C. Tran, S. H. Baek, R. Chen, R. Vessella, M. G. Rosenfeld, and C. L. Sawyers. 2004. Molecular determinants of resistance to antiandrogen therapy. Nat. Med. 10:33-39.
13. Chowdhury, S. K., A. Gemin, and G. Singh. 2005. High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Biochem. Biophys. Res. Commun. 333:1139-1145.
14. Edwards, J., and J. M. Bartlett. 2005. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: Androgen-receptor cofactors and bypass pathways. BJU Int. 95:1327-1335.
15. Fiser, A., and A. Sali. 2003. Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol. 374:461-491.
16. Frye, R. A. 2000. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273:793-798.
17. Fu, M., M. Rao, K. Wu, C. Wang, X. Zhang, M. Hessien, Y. G. Yeung, D. Gioeli, M. J. Weber, and R. G. Pestell. 2004. The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. J. Biol. Chem. 279:29436-29449.
18. Fu, M., C. Wang, A. T. Reutens, R. Angeletti, L. Siconolfi-Baez, V. Ogryzko, M. L. Avantaggiati, and R. G. Pestell. 2000. p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. J. Biol. Chem. 275: 20853-20860.
19. Fu, M., C. Wang, J. Wang, T. Sakamaki, D. Di Vizio, X. Zhang, C. Albanese, S. Balk, C. Chang, S. Fan, E. Rosen, J. J. Palvimo, O. A. Janne, S. Muratoglu, M. Avantaggiati, and R. G. Pestell. 2003. Acetylation of the androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Mol. Cell. Biol. 23:8563-8575.
20. Fu, M., C. Wang, J. Wang, T. Sakamaki, X. Zhang, Y.-G. Yeung, C. Chang, T. Hopp, S. A. W. Fuqua, E. Jaffray, R. T. Hay, J. J. Palvimo, O. A. Jänne, and R. G. Pestell. 2002. The androgen receptor acetylation governs transactivation and MEKK1-induced apoptosis without affecting in vitro sumoylation and transrepression function. Mol. Cell. Biol. 22:3373-3388.
21. Fu, M., C. Wang, J. Wang, B. Zafonte, M. P. Lisanti, and R. G. Pestell. 2002. Acetylation in hormone signaling and the cell-cycle. Cytokine Growth Factor Rev. 13:259-276.
22. Fulco, M., R. L. Schiltz, S. Iezzi, M. T. King, P. Zhao, Y. Kashiwaya, E. Hoffman, R. L. Veech, and V. Sartorelli. 2003. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12:51-62.
23. Gasser, S. M., and M. M. Cockell. 2001. The molecular biology of the SIR proteins. Gene 279:1-16.
24. Gingras, S., R. Moriggl, B. Groner, and J. Simard. 1999. Induction of 3β-hydroxysteroid dehydrogenase/δ5-δ4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13. Mol. Endocrinol. 13:66-81.
25. Gleason, D. F. 1966. Classification of prostatic carcinomas. Cancer Chemother. Rep. 50:125-128.
26. Gong, J., J. Zhu, O. B. Goodman, R. G. Pestell, P. N. Schlegel, D. M. Nanus, and R. Shen. 2006. Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells. Oncogene 25:2011-2021.
27. Grinspoon, S., C. Corcoran, K. Lee, B. Burrows, J. Hubbard, L. Katznelson, M. Walsh, A. Guccione, J. Cannan, H. Heller, N. Basgoz, and A. Klibanski. 1996. Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. J. Clin. Endocrinol. Metab. 81:4051-4058.
28. Reference deleted.
29. Ikonen, T., J. J. Palvimo, and O. A. Janne. 1997. Interaction between the amino- and carboxyl-terminal regions of the rat androgen receptor modulates transcriptional activity and is influenced by nuclear receptor coactivators. J. Biol. Chem. 272:29821-29828.
30. Imai, S., C. M. Armstrong, M. Kaeberlein, and L. Guarente. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800.
31. Jemal, A., T. Murray, A. Samuels, A. Ghafoor, E. Ward, and M. J. Thun. 2003. Cancer statistics, 2003. CA Cancer J. Clin. 53:5-26.
32. Kaeberlein, M., T. McDonagh, B. Heltweg, J. Hixon, E. A. Westman, S. D. Caldwell, A. Napper, R. Curtis, P. S. DiStefano, S. Fields, A. Bedalov, and B. K. Kennedy. 2005. Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280:17038-17045.
33. Landry, J., A. Sutton, S. T. Tafrov, R. C. Heller, J. Stebbins, L. Pillus, and R. Stemglanz. 2000. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA 97:5807-5811.
34. Lee, D. Y., C. Teyssier, B. D. Strahl, and M. R. Stallcup. 2005. Role of protein methylation in regulation of transcription. Endocr. Rev. 26:147-170.
35. Li, Z., C. Wang, X. Jiao, Y. Lu, M. Fu, A. A. Quong, C. Dye, J. Yang, M. Dai, X. Ju, X. Zhang, A. Li, P. Burbelo, E. R. Stanley, and R. G. Pestell. 2006. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol. Cell. Biol. 26:4240-4256.
36. Lin, S. J., P. A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289:2126-2128.
37. Lin, S. J., E. Ford, M. Haigis, G. Liszt, and L. Guarente. 2004. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 18:12-16.
38. Luo, J., A. Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu. 2001. Negative control of p53 by Sir2a promotes cell survival under stress. Cell 107:137-148.
39. Matsumura, I., T. Kitamura, H. Wakao, H. Tanaka, K. Hashimoto, C. Albanese, J. Downward, R. G. Pestell, and Y. Kanakura. 1999. Transcriptional regulation of cyclin Di promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J. 18:1367-1377.
40. Metzger, E., M. Wissmann, N. Yin, J. M. Muller, R. Schneider, A. H. Peters, T. Gunther, R. Buettner, and R. Schule. 2005. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437:436-439.
41. Min, J., J. Landry, R. Sternglanz, and R. M. Xu. 2001. Crystal structure of a SIR2 homolog-NAD complex. Cell 105:269-279.
42. Motta, M. C., N. Divecha, M. Lemieux, C. Kamel, D. Chen, W. Gu, Y. Bultsma, M. McBurney, and L. Guarente. 2004. Mammalian SIRT1 represses forkhead transcription factors. Cell 116:551-563.
43. 168, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J. 20:1353-1362.
44. Pettersen, E. F., T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, and T. E. Ferrin. 2004. UCSF Chimera-a visualization system for exploratory research and analysis. J. Comput. Chem. 25:1605-1612.
45. Reutens, A. T., M. Fu, G. Watanabe, C. Albanese, M. J. McPhaul, S. P. Balk, O. A. Janne, J. J. Palvimo, and R. G. Pestell. 2001. Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner. MolI. Endocrinol. 15: 797-811.
46. Revollo, J. R., A. A. Grimm, and S. Imai. 2004. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279:50754-50763.
47. Rossi, S., E. Graner, P. Febbo, L. Weinstein, N. Bhattacharya, T. Onody, G. Bubley, S. Balk, and M. Loda. 2003. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol. Cancer Res. 1:707-715.
48. Sathya, G., C. Y. Chang, D. Kazmin, C. E. Cook, and D. P. McDonnell. 2003. Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion. Cancer Res. 63: 8029-8036.
49. Sauve, A. A., I. Celic, J. Avalos, H. Deng, J. D. Boeke, and V. L. Schramm. 2001. Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. Biochem. 40:15456-15463.
50. Sauve, A. A., R. D. Moir, V. L. Schramm, and I. M. Willis. 2005. Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol. Cell 17:595-601.
51. Schroeder, E. T., M. Terk, and F. R. Sattler. 2003. Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies. Am. J. Physiol. Endocrinol. Metab. 285:E16-E24.
52. Seligson, D. B., S, Horvath, T. Shi, H. Yu, S. Tse, M. Grunstein, and S. K. Kurdistani. 2005. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 435:1262-1266.
53. Shi, Y., and C. Mello. 1998. A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. Genes Dev. 12:943-955.
54. Smith, J. S., C. B. Brachmann, I. Celic, M. A. Kenna, S. Muhammad, V. J. Starai, J. L. Avalos, J. C. Escalante-Semerena, C. Grubmeyer, C. Wolberger, et al. 2000. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA 97:6658-6663.
55. Vaquero, A., M. Scher, D. Lee, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 2004. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16:93-105.
56. Vaziri, H., S. K. Dessain, E. Ng-Eaton, S. I. Imai, R. A. Frye, T. K. Pandita, L. Guarente. and R. A. Weinberg. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159.
57. Wang, L., C. L. Hsu, and C. Chang. 2005. Androgen receptor corepressors: an overview. Prostate 63:117-130.
58. Yang, T., M. Fu, R. Pestell, and A. A. Sauve. 2006. SIRT1 and endocrine signaling. Trends Endocrinol Metab. 17:186-191.
59. Zhao, K., X. Chai, and R. Marmorstein. 2004. Structure and substrate binding properties of CobB, a Sir2 homolog protein deacetylase from Escherichia coli. J. Mol. Biol. 337:731-741.