Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Physiological Genomics

Volumn 16, Issue , 2004, Pages 29-37

  Van Remmen, Holly ^a,c   Ikeno, Yuji ^a,c   Hamilton, Michelle ^a   Pahlavani, Mohammad ^a   Wolf, Norman ^d   Thorpe, Suzanne R ^e   Alderson, Nathan L ^e   Baynes, John W ^e   Epstein, Charles J ^f   Huang, Ting Ting ^g   Nelson, James ^a   Strong, Randy ^a,b   Richardson, Arlan ^a,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Health Science Center   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF SOUTH CAROLINA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g STANFORD UNIVERSITY   (United States)

Author keywords

Mitochondria; Oxidative damage

Indexed keywords

BIOLOGICAL MARKER; COLLAGEN; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLINE; DEOXYGUANOSINE DERIVATIVE; DNA; LYSINE DERIVATIVE; MANGANESE SUPEROXIDE DISMUTASE; PENTOSIDINE;

AGING; ANIMAL TISSUE; ARTICLE; CANCER; CANCER INCIDENCE; DNA DAMAGE; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; GENE MUTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AGING; ANIMALS; BIOLOGICAL MARKERS; CATALASE; CELL DIVISION; DNA DAMAGE; DNA, MITOCHONDRIAL; FEMALE; GLUTATHIONE PEROXIDASE; HETEROZYGOTE; LONGEVITY; MICE; MICE, KNOCKOUT; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 12144288373     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00122.2003     Document Type: Article

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