Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Science

Volumn 305, Issue 5682, 2004, Pages 390-392

  Cohen, Haim Y ^a   Miller, Christine ^a   Bitterman, Kevin J ^a   Wall, Nathan R ^a   Hekking, Brian ^a   Kessler, Benedikt ^a   Howitz, Konrad T ^b   Gorospe, Myriam ^c   De Cabo, Rafael ^c   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BIOMOL Research Laboratories Inc   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING OF MATERIALS; INSULIN;

CALORIC RESTRICTIONS (CR); SERUM;

CELLS;

ACYLTRANSFERASE; INSULIN; PROTEIN BAX; SIRT1 DEACETYLASE; SIRTUIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

AGING; BIOLOGY;

AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; CALORIC RESTRICTION; CELL DEATH; CELL SURVIVAL; DNA REPAIR; ENZYME ACTIVATION; LIFESPAN; MAMMAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SURVIVAL TIME;

ACETYLATION; ADIPOSE TISSUE; ALLELES; ANIMALS; ANTIGENS, NUCLEAR; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALORIC RESTRICTION; CELL LINE; CELL SURVIVAL; DNA-BINDING PROTEINS; HISTONE DEACETYLASES; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; KIDNEY; LIVER; MALE; MITOCHONDRIA; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED F344; RNA, SMALL INTERFERING; SIRTUINS;

ANIMALIA; MAMMALIA;

EID: 3142740860     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099196     Document Type: Article

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25. We thank members of the Sinclair lab, Y. Shi, and J. L. Martindale for advice and technical assistance. This work was supported by NIH/Nationat Institute on Aging (NIA) grants AG19719-03 and AG19972-02. D.A.S. is an Ellison Medical Research Foundation Special Fellow. H.Y.C. is an Ellison/American Federation of Aging Research Senior Postdoctoral Fellow. K.J.B. is a Harvard MPM Scholar. N.R.W. is supported by National Research Service Award F32 CA097802 from the Cancer Training Branch/NCI, NIH.