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Volumn 3, Issue 8-9, 2004, Pages 845-854

The Mre11 complex and the metabolism of chromosome breaks: The importance of communicating and holding things together

Author keywords

ATM; Checkpoints; Double strand breaks; Mre11 complex

Indexed keywords

MRE11 PROTEIN; RAD50 PROTEIN;

EID: 3242891189     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2004.03.014     Document Type: Review
Times cited : (233)

References (87)
  • 1
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou B.B., Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature. 408:2000;433-439
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 2
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:2003;155-168
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 3
    • 0034020464 scopus 로고    scopus 로고
    • The Mre11 complex and ATM: Collaborating to navigate S phase
    • Petrini J.H. The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12:2000;293-296
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 293-296
    • Petrini, J.H.1
  • 4
    • 0000264268 scopus 로고    scopus 로고
    • The Mre11-Rad50 complex: Diverse functions in the cellular DNA damage response
    • M.F. Hoekstra, J.A. Nickoloff (Eds.), Humana Press, Totowa
    • R.S. Maser, D.A. Bressan, J.H.J. Petrini, The Mre11-Rad50 complex: diverse functions in the cellular DNA damage response, in: M.F. Hoekstra, J.A. Nickoloff (Eds.), DNA Damage and Repair, Humana Press, Totowa, 2001, pp. 147-172.
    • (2001) DNA Damage and Repair , pp. 147-172
    • Maser, R.S.1    Bressan, D.A.2    Petrini, J.H.J.3
  • 5
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors rad50, mre11, and p95
    • Trujillo K.M., Yuan S.S.F., Lee E., Sung P. Nuclease activities in a complex of human recombination and DNA repair factors rad50, mre11, and p95. J. Biol. Chem. 273:1998;21447-21450
    • (1998) J. Biol. Chem. , vol.273 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.S.F.2    Lee, E.3    Sung, P.4
  • 6
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney J.P., Maser R.S., Olivares H., Davis E.M., Le Beau M., Yates J.R. III, Hays L., Morgan W.F., Petrini J.H. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell. 93:1998;477-486
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.9
  • 7
    • 0029742576 scopus 로고    scopus 로고
    • Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
    • Dolganov G.M., Maser R.S., Novikov A., Tosto L., Chong S., Bressan D.A., Petrini J.H. Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol. 16:1996;4832-4841
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4832-4841
    • Dolganov, G.M.1    Maser, R.S.2    Novikov, A.3    Tosto, L.4    Chong, S.5    Bressan, D.A.6    Petrini, J.H.7
  • 8
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • Usui T., Ohta T., Oshiumi H., Tomizawa J., Ogawa H., Ogawa T. Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell. 95:1998;705-716
    • (1998) Cell , vol.95 , pp. 705-716
    • Usui, T.1    Ohta, T.2    Oshiumi, H.3    Tomizawa, J.4    Ogawa, H.5    Ogawa, T.6
  • 9
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull T.T., Gellert M. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 13:1999;1276-1288
    • (1999) Genes Dev. , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 10
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau S., Ferguson J.R., Symington L.S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19:1999;556-566
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 11
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
    • Paull T.T., Gellert M. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol. Cell. 1:1998;969-979
    • (1998) Mol. Cell. , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 12
    • 0025334351 scopus 로고
    • Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
    • Alani E., Padmore R., Kleckner N. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell. 61:1990;419-436
    • (1990) Cell , vol.61 , pp. 419-436
    • Alani, E.1    Padmore, R.2    Kleckner, N.3
  • 13
    • 0031664401 scopus 로고    scopus 로고
    • Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11
    • Bressan D.A., Olivares H.A., Nelms B.E., Petrini J.H. Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics. 150:1998;591-600
    • (1998) Genetics , vol.150 , pp. 591-600
    • Bressan, D.A.1    Olivares, H.A.2    Nelms, B.E.3    Petrini, J.H.4
  • 14
    • 0036163019 scopus 로고    scopus 로고
    • Differential Suppression of DNA repair deficiencies of yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase)
    • Lewis L.K., Karthikeyan G., Westmoreland J.W., Resnick M.A. Differential Suppression of DNA repair deficiencies of yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase). Genetics. 160:2002;49-62
    • (2002) Genetics , vol.160 , pp. 49-62
    • Lewis, L.K.1    Karthikeyan, G.2    Westmoreland, J.W.3    Resnick, M.A.4
  • 15
    • 0035692142 scopus 로고    scopus 로고
    • Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism
    • Moreau S., Morgan E.A., Symington L.S. Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics. 159:2001;1423-1433
    • (2001) Genetics , vol.159 , pp. 1423-1433
    • Moreau, S.1    Morgan, E.A.2    Symington, L.S.3
  • 16
    • 0033915812 scopus 로고    scopus 로고
    • Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae
    • Tsubouchi H., Ogawa H. Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae. Mol. Biol. Cell. 11:2000;2221-2233
    • (2000) Mol. Biol. Cell. , vol.11 , pp. 2221-2233
    • Tsubouchi, H.1    Ogawa, H.2
  • 17
    • 0032534704 scopus 로고    scopus 로고
    • Homologous recombination is required for the viability of rad27 mutants
    • Symington L.S. Homologous recombination is required for the viability of rad27 mutants. Nucleic Acids Res. 26:1998;5589-5595
    • (1998) Nucleic Acids Res. , vol.26 , pp. 5589-5595
    • Symington, L.S.1
  • 18
    • 0142011461 scopus 로고    scopus 로고
    • The cellular response to DNA double-strand breaks: Defining the sensors and mediators
    • Petrini J.H., Stracker T.H. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13:2003;458-462
    • (2003) Trends Cell Biol. , vol.13 , pp. 458-462
    • Petrini, J.H.1    Stracker, T.H.2
  • 20
    • 0035830498 scopus 로고    scopus 로고
    • Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
    • Myung K., Datta A., Kolodner R.D. Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell. 104:2001;397-408
    • (2001) Cell , vol.104 , pp. 397-408
    • Myung, K.1    Datta, A.2    Kolodner, R.D.3
  • 21
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:2003;499-506
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 24
    • 0037226818 scopus 로고    scopus 로고
    • DNA replication-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva O.K., Petrini J.H. DNA replication-dependent nuclear dynamics of the Mre11 complex. Mol. Cancer Res. 1:2003;207-218
    • (2003) Mol. Cancer Res. , vol.1 , pp. 207-218
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 25
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the mre11 complex
    • Mirzoeva O.K., Petrini J.H. DNA damage-dependent nuclear dynamics of the mre11 complex. Mol. Cell. Biol. 21:2001;281-288
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 30
    • 0036510055 scopus 로고    scopus 로고
    • The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
    • Falck J., Petrini J.H., Williams B.R., Lukas J., Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat. Genet. 30:2002;290-294
    • (2002) Nat. Genet. , vol.30 , pp. 290-294
    • Falck, J.1    Petrini, J.H.2    Williams, B.R.3    Lukas, J.4    Bartek, J.5
  • 31
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J., Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 3:2003;421-429
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 32
    • 0037341599 scopus 로고    scopus 로고
    • Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
    • Lukas C., Falck J., Bartkova J., Bartek J., Lukas J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell. Biol. 5:2003;255-260
    • (2003) Nat. Cell. Biol. , vol.5 , pp. 255-260
    • Lukas, C.1    Falck, J.2    Bartkova, J.3    Bartek, J.4    Lukas, J.5
  • 33
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck J., Mailand N., Syljuasen R.G., Bartek J., Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 410:2001;842-847
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Mailand, N.2    Syljuasen, R.G.3    Bartek, J.4    Lukas, J.5
  • 35
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim S.-T., Xu B., Kastan M.B. Involvement of the cohesin protein Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16:2002;560-570
    • (2002) Genes Dev. , vol.16 , pp. 560-570
    • Kim, S.-T.1    Xu, B.2    Kastan, M.B.3
  • 37
    • 0035930329 scopus 로고    scopus 로고
    • Human Rad50/Mre11 is a flexible complex that can tether DNA ends
    • de Jager M., Noort V. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell. 8:2001;1129-1135
    • (2001) Mol. Cell. , vol.8 , pp. 1129-1135
    • De Jager, M.1    Noort, V.2
  • 39
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • Xiao Y., Weaver D.T. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25:1997;2985-2991
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 40
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • Zhu J., Petersen S., Tessarollo L., Nussenzweig A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11:2001;105-109
    • (2001) Curr. Biol. , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4
  • 41
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • Luo G., Yao M.S., Bender C.F., Mills M., Bladl A.R., Bradley A., Petrini J.H. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl. Acad. Sci. U.S.A. 96:1999;7376-7381
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 44
    • 0037086702 scopus 로고    scopus 로고
    • Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
    • Kang J., Bronson R., Xu Y. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. EMBO J. 21:2002;1447-1455
    • (2002) EMBO J. , vol.21 , pp. 1447-1455
    • Kang, J.1    Bronson, R.2    Xu, Y.3
  • 45
    • 0036900120 scopus 로고    scopus 로고
    • Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
    • (table of contents)
    • Symington L.S. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol. Mol. Biol. Rev. 66:2002;630-670. (table of contents)
    • (2002) Microbiol. Mol. Biol. Rev. , vol.66 , pp. 630-670
    • Symington, L.S.1
  • 46
    • 0142147272 scopus 로고    scopus 로고
    • The BRCT domain is a phospho-protein binding domain
    • Yu X., Chini C.C., He M., Mer G., Chen J. The BRCT domain is a phospho-protein binding domain. Science. 302:2003;639-642
    • (2003) Science , vol.302 , pp. 639-642
    • Yu, X.1    Chini, C.C.2    He, M.3    Mer, G.4    Chen, J.5
  • 47
    • 0142240342 scopus 로고    scopus 로고
    • BRCT repeats as phosphopeptide-binding modules involved in protein targeting
    • Manke I.A., Lowery D.M., Nguyen A., Yaffe M.B. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 302:2003;636-639
    • (2003) Science , vol.302 , pp. 636-639
    • Manke, I.A.1    Lowery, D.M.2    Nguyen, A.3    Yaffe, M.B.4
  • 48
    • 0033638454 scopus 로고    scopus 로고
    • The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms
    • Durocher D., Taylor I.A., Sarbassova D., Haire L.F., Westcott S.L., Jackson S.P., Smerdon S.J., Yaffe M.B. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell. 6:2000;1169-1182
    • (2000) Mol. Cell. , vol.6 , pp. 1169-1182
    • Durocher, D.1    Taylor, I.A.2    Sarbassova, D.3    Haire, L.F.4    Westcott, S.L.5    Jackson, S.P.6    Smerdon, S.J.7    Yaffe, M.B.8
  • 50
    • 0035068565 scopus 로고    scopus 로고
    • An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele
    • Maser R.S., Zinkel R., Petrini J.H.J. An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Nat. Genet. 27:2001;417-421
    • (2001) Nat. Genet. , vol.27 , pp. 417-421
    • Maser, R.S.1    Zinkel, R.2    Petrini, J.H.J.3
  • 55
    • 0037007074 scopus 로고    scopus 로고
    • Inaugural article: Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae
    • Myung K., Kolodner R.D. Inaugural article: suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 99:2002;4500-4507
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 4500-4507
    • Myung, K.1    Kolodner, R.D.2
  • 58
    • 0034841849 scopus 로고    scopus 로고
    • Introducing defined chromosomal rearrangements into the mouse genome
    • Zheng B., Mills A.A., Bradley A. Introducing defined chromosomal rearrangements into the mouse genome. Methods. 24:2001;81-94
    • (2001) Methods , vol.24 , pp. 81-94
    • Zheng, B.1    Mills, A.A.2    Bradley, A.3
  • 59
    • 0033985437 scopus 로고    scopus 로고
    • Engineering mouse chromosomes with Cre-loxP: Range, efficiency, and somatic applications
    • Zheng B., Sage M., Sheppeard E.A., Jurecic V., Bradley A. Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol. Cell. Biol. 20:2000;648-655
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 648-655
    • Zheng, B.1    Sage, M.2    Sheppeard, E.A.3    Jurecic, V.4    Bradley, A.5
  • 60
    • 0030885998 scopus 로고    scopus 로고
    • Mre11S-a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis
    • Nairz K., Klein F. Mre11S-a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis. Genes Dev. 11:1997;2272-2290
    • (1997) Genes Dev. , vol.11 , pp. 2272-2290
    • Nairz, K.1    Klein, F.2
  • 61
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • Furuse M., Nagase Y., Tsubouchi H., Murakami-Murofushi K., Shibata T., Ohta K. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 17:1998;6412-6425
    • (1998) EMBO J. , vol.17 , pp. 6412-6425
    • Furuse, M.1    Nagase, Y.2    Tsubouchi, H.3    Murakami-Murofushi, K.4    Shibata, T.5    Ohta, K.6
  • 62
    • 0028789631 scopus 로고
    • Covalent protein-DNA complexes at the 5′ strand termini of meiosis-specific double-strand breaks in yeast
    • Keeney S., Kleckner N. Covalent protein-DNA complexes at the 5′ strand termini of meiosis-specific double-strand breaks in yeast. Proc. Natl. Acad. Sci. U.S.A. 92:1995;11274-11278
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 11274-11278
    • Keeney, S.1    Kleckner, N.2
  • 63
    • 0030893115 scopus 로고    scopus 로고
    • Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family
    • Keeney S., Giroux C.N., Kleckner N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell. 88:1997;375-384
    • (1997) Cell , vol.88 , pp. 375-384
    • Keeney, S.1    Giroux, C.N.2    Kleckner, N.3
  • 64
    • 0035902495 scopus 로고    scopus 로고
    • Links between replication and recombination in Saccharomyces cerevisiae: A hypersensitive requirement for homologous recombination in the absence of Rad27 activity
    • Debrauwere H., Loeillet S., Lin W., Lopes J., Nicolas A. Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8263-8269
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 8263-8269
    • Debrauwere, H.1    Loeillet, S.2    Lin, W.3    Lopes, J.4    Nicolas, A.5
  • 65
    • 0034964498 scopus 로고    scopus 로고
    • A DNA damage response pathway controlled by Tel1 and the Mre11 complex
    • Usui T., Ogawa H., Petrini J.H. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell. 7:2001;1255-1266
    • (2001) Mol. Cell. , vol.7 , pp. 1255-1266
    • Usui, T.1    Ogawa, H.2    Petrini, J.H.3
  • 68
    • 0031466618 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
    • Shiloh Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31:1997;635-662
    • (1997) Annu. Rev. Genet. , vol.31 , pp. 635-662
    • Shiloh, Y.1
  • 70
    • 0000770165 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome
    • T.I.N.B.S.S. Group, Nijmegen breakage syndrome, Arch. Dis. Child 82 (2000) 400-406.
    • (2000) Arch. Dis. Child , vol.82 , pp. 400-406
  • 73
    • 0030786912 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation
    • Jongmans W., Vuillaume M., Chrzanowska K., Smeets D., Sperling K., Hall J. Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol. Cell. Biol. 17:1997;5016-5022
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5016-5022
    • Jongmans, W.1    Vuillaume, M.2    Chrzanowska, K.3    Smeets, D.4    Sperling, K.5    Hall, J.6
  • 74
    • 0032101583 scopus 로고    scopus 로고
    • Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells
    • Yamazaki V., Wegner R.D., Kirchgessner C.U. Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells. Cancer Res. 58:1998;2316-2322
    • (1998) Cancer Res. , vol.58 , pp. 2316-2322
    • Yamazaki, V.1    Wegner, R.D.2    Kirchgessner, C.U.3
  • 75
    • 0037142619 scopus 로고    scopus 로고
    • Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest
    • Girard P.M., Riballo E., Begg A.C., Waugh A., Jeggo P.A. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene. 21:2002;4191-4199
    • (2002) Oncogene , vol.21 , pp. 4191-4199
    • Girard, P.M.1    Riballo, E.2    Begg, A.C.3    Waugh, A.4    Jeggo, P.A.5
  • 76
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brcal in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu B., Kim S., Kastan M.B. Involvement of Brcal in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21:2001;3445-3450
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.2    Kastan, M.B.3
  • 79
    • 0034650582 scopus 로고    scopus 로고
    • Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice
    • Bishop A.J., Barlow C., Wynshaw-Boris A.J., Schiestl R.H. Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice. Cancer Res. 60:2000;395-399
    • (2000) Cancer Res. , vol.60 , pp. 395-399
    • Bishop, A.J.1    Barlow, C.2    Wynshaw-Boris, A.J.3    Schiestl, R.H.4
  • 81
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu Y., Ashley T., Brainerd E.E., Bronson R.T., Meyn M.S., Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:1996;2411-2422
    • (1996) Genes Dev. , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 83
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
    • D'Amours D., Jackson S.P. The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell. Biol. 3:2002;317-327
    • (2002) Nat. Rev. Mol. Cell. Biol. , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 85
    • 0034997651 scopus 로고    scopus 로고
    • Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
    • Desai-Mehta A., Cerosaletti K.M., Concannon P. Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol. Cell. Biol. 21:2001;2184-2191
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2184-2191
    • Desai-Mehta, A.1    Cerosaletti, K.M.2    Concannon, P.3


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