Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

Cell Metabolism

Volumn 2, Issue 1, 2005, Pages 67-76

  Chua, Katrin F ^a,d   Mostoslavsky, Raul ^a   Lombard, David B ^a,c   Pang, Wendy W ^a   Saito, Shin'ichi ^b   Franco, Sonia ^a   Kaushal, Dhruv ^a   Cheng, Hwei Ling ^a   Fischer, Miriam R ^a   Stokes, Nicole ^a   Murphy, Michael M ^a   Appella, Ettore ^b   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEIN P190; PROTEIN P53; SILENT INFORMATION REGULATOR PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 1; SILENT INFORMATION REGULATOR PROTEIN 2; UNCLASSIFIED DRUG; CDKN2A PROTEIN, MOUSE; DOXORUBICIN; HYDROGEN PEROXIDE; PROTEIN P14ARF; PROTEIN P16INK4A; SIRT1 PROTEIN, MOUSE; SIRTUIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; FEMALE; FIBROBLAST; GENE EXPRESSION; GENOMIC INSTABILITY; LIFESPAN; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; SENESCENCE; UPREGULATION; ANIMAL; CELL AGING; CELL CYCLE S PHASE; CELL STRAIN 3T3; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; ONCOGENE RAS;

ANIMALIA; MAMMALIA; SACCHAROMYCES CEREVISIAE;

ANIMALS; CELL AGING; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; DOXORUBICIN; FIBROBLASTS; GENES, RAS; HYDROGEN PEROXIDE; MICE; MICE, KNOCKOUT; NIH 3T3 CELLS; OXIDATIVE STRESS; S PHASE; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 27244435939     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2005.06.007     Document Type: Article

References (64)

1. S.U. Astrom T.W. Cline J. Rine The Drosophila melanogaster sir2(+) gene is nonessential and has only minor effects on position-effect variegation Genetics 163 2003 931-937
2. N. Bardeesy M. Sinha A.F. Hezel S. Signoretti N.A. Hathaway N.E. Sharpless M. Loda D.R. Carrasco R.A. DePinho Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation Nature 419 2002 162-167
3. Ben-Porath and Weinberg, 2004 I. Ben-Porath R.A. Weinberg When cells get stressed: An integrative view of cellular senescence J. Clin. Invest. 113 2004 8-13
4. G. Blander L. Guarente The sir2 family of protein deacetylases Annu. Rev. Biochem. 73 2004 417-435
5. A. Brunet L.B. Sweeney J.F. Sturgill K.F. Chua P.L. Greer Y. Lin H. Tran S.E. Ross R. Mostoslavsky H.Y. Cohen et. al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011-2015
6. R.A. Busuttil M. Dolle J. Campisi J. Vijg Genomic instability, aging, and cellular senescence Ann. N Y Acad. Sci. 1019 2004 245-255
7. J. Campisi Aging and cancer: The double-edged sword of replicative senescence J. Am. Geriatr. Soc. 45 1997 482-488
8. J. Campisi Cancer, aging and cellular senescence In Vivo 14 2000 183-188
9. H. Carlson S. Ota Y. Song Y. Chen P.J. Hurlin Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation Oncogene 21 2002 3827-3835
10. Q. Chen A. Fischer J.D. Reagan L.J. Yan B.N. Ames Oxidative DNA damage and senescence of human diploid fibroblast cells Proc. Natl. Acad. Sci. USA 92 1995 4337-4341
11. H. Cheng R. Mostoslavsky S. Saito J.P. Manis Y. Gu P. Patel R. Bronson E. Appella F.W. Alt K.F. Chua Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice Proc. Natl. Acad. Sci. USA 100 2003 10794-10799
12. H.Y. Cohen S. Lavu K.J. Bitterman B. Hekking T.A. Imahiyerobo C. Miller R. Frye H. Ploegh B.M. Kessler D.A. Sinclair Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis Mol. Cell 13 2004 627-638
13. H.Y. Cohen C. Miller K.J. Bitterman N.R. Wall B. Hekking B. Kessler K.T. Howitz M. Gorospe R. de Cabo D.A. Sinclair Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390-392
14. H. Daitoku M. Hatta H. Matsuzaki S. Aratani T. Ohshima M. Miyagishi T. Nakajima A. Fukamizu Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proc. Natl. Acad. Sci. USA 101 2004 10042-10047
15. J.H. Dannenberg A. van Rossum L. Schuijff H. te Riele Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions Genes Dev. 14 2000 3051-3064
16. T. Finkel N.J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 408 2000 239-247
17. R.A. Frye Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins Biochem. Biophys. Res. Commun. 273 2000 793-798
18. L. Hayflick P.S. Moorhead The serial cultivation of human diploid cell strains Exp. Cell Res. 25 1961 585-621
19. K. Irani Y. Xia J.L. Zweier S.J. Sollott C.J. Der E.R. Fearon M. Sundaresan T. Finkel P.J. Goldschmidt-Clermont Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts Science 275 1997 1649-1652
20. A. Iwama H. Oguro M. Negishi Y. Kato Y. Morita H. Tsukui H. Ema T. Kamijo Y. Katoh-Fukui H. Koseki et. al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1 Immunity 21 2004 843-851
21. J.J. Jacobs K. Kieboom S. Marino R.A. DePinho M. van Lohuizen The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus Nature 397 1999 164-168
22. J.J. Jacobs P. Keblusek E. Robanus-Maandag P. Kristel M. Lingbeek P.M. Nederlof T. van Welsem M.J. van de Vijver E.Y. Koh G.Q. Daley M. van Lohuizen Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers Nat. Genet. 26 2000 291-299
23. M. Kaeberlein M. McVey L. Guarente The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Genes Dev. 13 1999 2570-2580
24. T. Kamijo F. Zindy M.F. Roussel D.E. Quelle J.R. Downing R.A. Ashmun G. Grosveld C.J. Sherr Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF Cell 91 1997 649-659
25. K.R. Kranc S.D. Bamforth J. Braganca C. Norbury M. van Lohuizen S. Bhattacharya Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF Mol. Cell. Biol. 23 2003 7658-7666
26. A. Krtolica J. Campisi Cancer and aging: A model for the cancer promoting effects of the aging stroma Int. J. Biochem. Cell Biol. 34 2002 1401-1414
27. M.L. Kuo W. den Besten C.J. Sherr N-terminal polyubiquitination of the ARF tumor suppressor, a natural lysine-less protein Cell Cycle 3 2004 1367-1369
28. K. Kurokawa T. Tanaka J. Kato p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts Oncogene 18 1999 2718-2727
29. E. Langley M. Pearson M. Faretta U.M. Bauer R.A. Frye S. Minucci P.G. Pelicci T. Kouzarides Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence EMBO J. 21 2002 2383-2396
30. A.C. Lee B.E. Fenster H. Ito K. Takeda N.S. Bae T. Hirai Z.X. Yu V.J. Ferrans B.H. Howard T. Finkel Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species J. Biol. Chem. 274 1999 7936-7940
31. J. Luo A.Y. Nikolaev S. Imai D. Chen F. Su A. Shiloh L. Guarente W. Gu Negative control of p53 by Sir2alpha promotes cell survival under stress Cell 107 2001 137-148
32. T. Maeda R.M. Hobbs T. Merghoub I. Guernah A. Zelent C. Cordon-Cardo J. Teruya-Feldstein P.P. Pandolfi Role of the proto-oncogene Pokemon in cellular transformation and ARF repression Nature 433 2005 278-285
33. M.W. McBurney X. Yang K. Jardine M. Hixon K. Boekelheide J.R. Webb P.M. Lansdorp M. Lemieux The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis Mol. Cell. Biol. 23 2003 38-54
34. M. Mikula E. Fuchs H. Huber H. Beug R. Schulte-Hermann W. Mikulits Immortalized p19ARF null hepatocytes restore liver injury and generate hepatic progenitors after transplantation Hepatology 39 2004 628-634
35. M.C. Motta N. Divecha M. Lemieux C. Kamel D. Chen W. Gu Y. Bultsma M. McBurney L. Guarente Mammalian SIRT1 represses forkhead transcription factors Cell 116 2004 551-563
36. S. Nemoto T. Finkel Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway Science 295 2002 2450-2452
37. S. Nemoto M.M. Fergusson T. Finkel Nutrient availability regulates SIRT1 through a forkhead-dependent pathway Science 306 2004 2105-2108
38. Oren, 2003 M. Oren Decision making by p53: Life, death and cancer Cell Death Differ. 10 2003 431-442
39. I. Palmero M. Serrano Induction of senescence by oncogenic Ras Methods Enzymol. 333 2001 247-256
40. I. Palmero C. Pantoja M. Serrano p19ARF links the tumour suppressor p53 to Ras Nature 395 1998 125-126
41. S. Parrinello E. Samper A. Krtolica J. Goldstein S. Melov J. Campisi Oxygen sensitivity severely limits the replicative life span of murine fibroblasts Nat. Cell Biol. 5 2003 741-747
42. M. Pearson R. Carbone C. Sebastiani M. Cioce M. Fagioli S. Saito Y. Higashimoto E. Appella S. Minucci P.P. Pandolfi P.G. Pelicci PML regulates p53 acetylation and premature senescence induced by oncogenic Ras Nature 406 2000 207-210
43. J. Pomerantz N. Schreiber-Agus N.J. Liegeois A. Silverman L. Alland L. Chin J. Potes K. Chen I. Orlow H.W. Lee et. al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2, and neutralizes MDM2's inhibition of p53 Cell 92 1998 713-723
44. C. Prives J.L. Manley Why is p53 acetylated? Cell 107 2001 815-818
45. D.E. Quelle F. Zindy R.A. Ashmun C.J. Sherr Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest Cell 83 1995 993-1000
46. S.J. Robles G.R. Adami Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts Oncogene 16 1998 1113-1123
47. B. Rogina S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998-16003
48. J. Sage G.J. Mulligan L.D. Attardi A. Miller S. Chen B. Williams E. Theodorou T. Jacks Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization Genes Dev. 14 2000 3037-3050
49. O.A. Sedelnikova I. Horikawa D.B. Zimonjic N.C. Popescu W.M. Bonner J.C. Barrett Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks Nat. Cell Biol. 6 2004 168-170
50. M. Serrano A.W. Lin M.E. McCurrach D. Beach S.W. Lowe Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88 1997 593-602
51. C.J. Sherr R.A. DePinho Cellular senescence: mitotic clock or culture shock? Cell 102 2000 407-410
52. D.A. Sinclair L. Guarente Extrachromosomal rDNA circles - a cause of aging in yeast Cell 91 1997 1033-1042
53. F.J. Stott S. Bates M.C. James B.B. McConnell M. Starborg S. Brookes I. Palmero K. Ryan E. Hara K.H. Vousden G. Peters The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2 EMBO J. 17 1998 5001-5014
54. M. Sundaresan Z.X. Yu V.J. Ferrans D.J. Sulciner J.S. Gutkind K. Irani P.J. Goldschmidt-Clermont T. Finkel Regulation of reactive-oxygen-species generation in fibroblasts by Rac1 Biochem. J. 318 1996 379-382
55. H.A. Tissenbaum L. Guarente Increased dosage of a sir-2 gene extends life span in Caenorhabditis elegans Nature 410 2001 227-230
56. G.J. Todaro H. Green Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines J. Cell Biol. 17 1963 299-313
57. A. Van Der Horst L.G. Tertoolen L.M. De Vries-Smits R.A. Frye R.H. Medema B.M. Burgering FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1 J. Biol. Chem. 279 2004 28873-28879
58. H. Vaziri S.K. Dessain E. Ng Eaton S.I. Imai R.A. Frye T.K. Pandita L. Guarente R.A. Weinberg hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 2001 149-159
59. K.H. Vousden X. Lu Live or let die: The cell's response to p53 Nat. Rev. Cancer 2 2002 594-604
60. J.G. Wood B. Rogina S. Lavu K. Howitz S.L. Helfand M. Tatar D. Sinclair Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 2004 686-689
61. W.E. Wright J.W. Shay Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology Nat. Med. 6 2000 849-851
62. Y. Zhang Y. Xiong W.G. Yarbrough ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways Cell 92 1998 725-734
63. F. Zindy D.E. Quelle M.F. Roussel C.J. Sherr Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging Oncogene 15 1997 203-211
64. F. Zindy C.M. Eischen D.H. Randle T. Kamijo J.L. Cleveland C.J. Sherr M.F. Roussel Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization Genes Dev. 12 1998 2424-2433