-
1
-
-
0345636016
-
Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
-
Allsopp R.C., Morin G.B., Horner J.W., DePinho R., Harley C.B., and Weissman I.L. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat. Med. 9 (2003) 369-371
-
(2003)
Nat. Med.
, vol.9
, pp. 369-371
-
-
Allsopp, R.C.1
Morin, G.B.2
Horner, J.W.3
DePinho, R.4
Harley, C.B.5
Weissman, I.L.6
-
2
-
-
2942547243
-
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics
-
Aslanian A., Iaquinta P.J., Verona R., and Lees J.A. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 18 (2004) 1413-1422
-
(2004)
Genes Dev.
, vol.18
, pp. 1413-1422
-
-
Aslanian, A.1
Iaquinta, P.J.2
Verona, R.3
Lees, J.A.4
-
3
-
-
33645824724
-
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
-
Bardeesy N., Aguirre A.J., Chu G.C., Cheng K.H., Lopez L.V., Hezel A.F., Feng B., Brennan C., Weissleder R., Mahmood U., et al. Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc. Natl. Acad. Sci. USA 103 (2006) 5947-5952
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5947-5952
-
-
Bardeesy, N.1
Aguirre, A.J.2
Chu, G.C.3
Cheng, K.H.4
Lopez, L.V.5
Hezel, A.F.6
Feng, B.7
Brennan, C.8
Weissleder, R.9
Mahmood, U.10
-
4
-
-
0032504783
-
p14ARF links the tumour suppressors RB and p53
-
Bates S., Phillips A.C., Clark P.A., Stott F., Peters G., Ludwig R.L., and Vousden K.H. p14ARF links the tumour suppressors RB and p53. Nature 395 (1998) 124-125
-
(1998)
Nature
, vol.395
, pp. 124-125
-
-
Bates, S.1
Phillips, A.C.2
Clark, P.A.3
Stott, F.4
Peters, G.5
Ludwig, R.L.6
Vousden, K.H.7
-
5
-
-
4744371446
-
The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue
-
Ben-Saadon R., Fajerman I., Ziv T., Hellman U., Schwartz A.L., and Ciechanover A. The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue. J. Biol. Chem. 279 (2004) 41414-41421
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41414-41421
-
-
Ben-Saadon, R.1
Fajerman, I.2
Ziv, T.3
Hellman, U.4
Schwartz, A.L.5
Ciechanover, A.6
-
6
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig M., Lee S., Loddenkemper C., Rudolph C., Peters A.H., Schlegelberger B., Stein H., Dorken B., Jenuwein T., and Schmitt C.A. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436 (2005) 660-665
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.5
Schlegelberger, B.6
Stein, H.7
Dorken, B.8
Jenuwein, T.9
Schmitt, C.A.10
-
7
-
-
20544453888
-
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
-
Bruggeman S.W., Valk-Lingbeek M.E., van der Stoop P.P., Jacobs J.J., Kieboom K., Tanger E., Hulsman D., Leung C., Arsenijevic Y., Marino S., and van Lohuizen M. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev. 19 (2005) 1438-1443
-
(2005)
Genes Dev.
, vol.19
, pp. 1438-1443
-
-
Bruggeman, S.W.1
Valk-Lingbeek, M.E.2
van der Stoop, P.P.3
Jacobs, J.J.4
Kieboom, K.5
Tanger, E.6
Hulsman, D.7
Leung, C.8
Arsenijevic, Y.9
Marino, S.10
van Lohuizen, M.11
-
8
-
-
1842483852
-
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
-
Bulavin D.V., Phillips C., Nannenga B., Timofeev O., Donehower L.A., Anderson C.W., Appella E., and Fornace Jr. A.J. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 36 (2004) 343-350
-
(2004)
Nat. Genet.
, vol.36
, pp. 343-350
-
-
Bulavin, D.V.1
Phillips, C.2
Nannenga, B.3
Timofeev, O.4
Donehower, L.A.5
Anderson, C.W.6
Appella, E.7
Fornace Jr., A.J.8
-
9
-
-
0034745679
-
Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer
-
Burri N., Shaw P., Bouzourene H., Sordat I., Sordat B., Gillet M., Schorderet D., Bosman F.T., and Chaubert P. Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. Lab. Invest. 81 (2001) 217-229
-
(2001)
Lab. Invest.
, vol.81
, pp. 217-229
-
-
Burri, N.1
Shaw, P.2
Bouzourene, H.3
Sordat, I.4
Sordat, B.5
Gillet, M.6
Schorderet, D.7
Bosman, F.T.8
Chaubert, P.9
-
10
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 (2005) 513-522
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
11
-
-
10344260912
-
Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts
-
Chen J.H., Stoeber K., Kingsbury S., Ozanne S.E., Williams G.H., and Hales C.N. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J. Biol. Chem. 279 (2004) 49439-49446
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49439-49446
-
-
Chen, J.H.1
Stoeber, K.2
Kingsbury, S.3
Ozanne, S.E.4
Williams, G.H.5
Hales, C.N.6
-
12
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
Chen Z., Trotman L.C., Shaffer D., Lin H.K., Dotan Z.A., Niki M., Koutcher J.A., Scher H.I., Ludwig T., Gerald W., et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436 (2005) 725-730
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.K.4
Dotan, Z.A.5
Niki, M.6
Koutcher, J.A.7
Scher, H.I.8
Ludwig, T.9
Gerald, W.10
-
13
-
-
23244447893
-
Tumour biology: senescence in premalignant tumours
-
Collado M., Gil J., Efeyan A., Guerra C., Schuhmacher A.J., Barradas M., Benguria A., Zaballos A., Flores J.M., Barbacid M., et al. Tumour biology: senescence in premalignant tumours. Nature 436 (2005) 642
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguria, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
-
14
-
-
33645526300
-
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant
-
Colombo E., Martinelli P., Zamponi R., Shing D.C., Bonetti P., Luzi L., Volorio S., Bernard L., Pruneri G., Alcalay M., and Pelicci P.G. Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant. Cancer Res. 66 (2006) 3044-3050
-
(2006)
Cancer Res.
, vol.66
, pp. 3044-3050
-
-
Colombo, E.1
Martinelli, P.2
Zamponi, R.3
Shing, D.C.4
Bonetti, P.5
Luzi, L.6
Volorio, S.7
Bernard, L.8
Pruneri, G.9
Alcalay, M.10
Pelicci, P.G.11
-
15
-
-
0034704848
-
p16 INK4a can initiate an autonomous senescence program
-
Dai C.Y., and Enders G.H. p16 INK4a can initiate an autonomous senescence program. Oncogene 19 (2000) 1613-1622
-
(2000)
Oncogene
, vol.19
, pp. 1613-1622
-
-
Dai, C.Y.1
Enders, G.H.2
-
16
-
-
0033562357
-
Dynamic changes in mouse hematopoietic stem cell numbers during aging
-
de Haan G., and Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 93 (1999) 3294-3301
-
(1999)
Blood
, vol.93
, pp. 3294-3301
-
-
de Haan, G.1
Van Zant, G.2
-
17
-
-
0030738479
-
Distinct roles for E2F proteins in cell growth control and apoptosis
-
DeGregori J., Leone G., Miron A., Jakoi L., and Nevins J.R. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94 (1997) 7245-7250
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 7245-7250
-
-
DeGregori, J.1
Leone, G.2
Miron, A.3
Jakoi, L.4
Nevins, J.R.5
-
19
-
-
19944427850
-
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
-
Falini B., Mecucci C., Tiacci E., Alcalay M., Rosati R., Pasqualucci L., La Starza R., Diverio D., Colombo E., Santucci A., et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N. Engl. J. Med. 352 (2005) 254-266
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 254-266
-
-
Falini, B.1
Mecucci, C.2
Tiacci, E.3
Alcalay, M.4
Rosati, R.5
Pasqualucci, L.6
La Starza, R.7
Diverio, D.8
Colombo, E.9
Santucci, A.10
-
20
-
-
31444451841
-
Cosmic 2005
-
Forbes S., Clements J., Dawson E., Bamford S., Webb T., Dogan A., Flanagan A., Teague J., Wooster R., Futreal P.A., and Stratton M.R. Cosmic 2005. Br. J. Cancer 94 (2006) 318-322
-
(2006)
Br. J. Cancer
, vol.94
, pp. 318-322
-
-
Forbes, S.1
Clements, J.2
Dawson, E.3
Bamford, S.4
Webb, T.5
Dogan, A.6
Flanagan, A.7
Teague, J.8
Wooster, R.9
Futreal, P.A.10
Stratton, M.R.11
-
21
-
-
15744376691
-
Toward biochemical understanding of a transcriptionally silenced chromosomal domain in Saccharomyces cerevisiae
-
Fox C.A., and McConnell K.H. Toward biochemical understanding of a transcriptionally silenced chromosomal domain in Saccharomyces cerevisiae. J. Biol. Chem. 280 (2005) 8629-8632
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 8629-8632
-
-
Fox, C.A.1
McConnell, K.H.2
-
23
-
-
33645460360
-
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
-
Gonzalez S., Klatt P., Delgado S., Conde E., Lopez-Rios F., Sanchez-Cespedes M., Mendez J., Antequera F., and Serrano M. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440 (2006) 702-706
-
(2006)
Nature
, vol.440
, pp. 702-706
-
-
Gonzalez, S.1
Klatt, P.2
Delgado, S.3
Conde, E.4
Lopez-Rios, F.5
Sanchez-Cespedes, M.6
Mendez, J.7
Antequera, F.8
Serrano, M.9
-
24
-
-
33747192833
-
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
-
Gray-Schopfer V.C., Cheong S.C., Chong H., Chow J., Moss T., Abdel-Malek Z.A., Marais R., Wynford-Thomas D., and Bennett D.C. Cellular senescence in naevi and immortalisation in melanoma: a role for p16?. Br. J. Cancer 95 (2006) 496-505
-
(2006)
Br. J. Cancer
, vol.95
, pp. 496-505
-
-
Gray-Schopfer, V.C.1
Cheong, S.C.2
Chong, H.3
Chow, J.4
Moss, T.5
Abdel-Malek, Z.A.6
Marais, R.7
Wynford-Thomas, D.8
Bennett, D.C.9
-
25
-
-
0037468254
-
Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants
-
Greenblatt M.S., Beaudet J.G., Gump J.R., Godin K.S., Trombley L., Koh J., and Bond J.P. Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants. Oncogene 22 (2003) 1150-1163
-
(2003)
Oncogene
, vol.22
, pp. 1150-1163
-
-
Greenblatt, M.S.1
Beaudet, J.G.2
Gump, J.R.3
Godin, K.S.4
Trombley, L.5
Koh, J.6
Bond, J.P.7
-
26
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U., Ferreira M., Condel L., Carey D., and Sedivy J.M. Cellular senescence in aging primates. Science 311 (2006) 1257
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
27
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig U., Jobling W.A., Chen B.P., Chen D.J., and Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 (2004) 501-513
-
(2004)
Mol. Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.3
Chen, D.J.4
Sedivy, J.M.5
-
28
-
-
0030046322
-
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
-
Herman J.G., Jen J., Merlo A., and Baylin S.B. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res. 56 (1996) 722-727
-
(1996)
Cancer Res.
, vol.56
, pp. 722-727
-
-
Herman, J.G.1
Jen, J.2
Merlo, A.3
Baylin, S.B.4
-
29
-
-
0037093319
-
Germline mutation of ARF in a melanoma kindred
-
Hewitt C., Lee Wu C., Evans G., Howell A., Elles R.G., Jordan R., Sloan P., Read A.P., and Thakker N. Germline mutation of ARF in a melanoma kindred. Hum. Mol. Genet. 11 (2002) 1273-1279
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 1273-1279
-
-
Hewitt, C.1
Lee Wu, C.2
Evans, G.3
Howell, A.4
Elles, R.G.5
Jordan, R.6
Sloan, P.7
Read, A.P.8
Thakker, N.9
-
30
-
-
18644365331
-
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts
-
Huot T.J., Rowe J., Harland M., Drayton S., Brookes S., Gooptu C., Purkis P., Fried M., Bataille V., Hara E., et al. Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol. Cell. Biol. 22 (2002) 8135-8143
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8135-8143
-
-
Huot, T.J.1
Rowe, J.2
Harland, M.3
Drayton, S.4
Brookes, S.5
Gooptu, C.6
Purkis, P.7
Fried, M.8
Bataille, V.9
Hara, E.10
-
31
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K., Hirao A., Arai F., Matsuoka S., Takubo K., Hamaguchi I., Nomiyama K., Hosokawa K., Sakurada K., Nakagata N., et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431 (2004) 997-1002
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Matsuoka, S.4
Takubo, K.5
Hamaguchi, I.6
Nomiyama, K.7
Hosokawa, K.8
Sakurada, K.9
Nakagata, N.10
-
32
-
-
33645730667
-
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
-
Ito K., Hirao A., Arai F., Takubo K., Matsuoka S., Miyamoto K., Ohmura M., Naka K., Hosokawa K., Ikeda Y., and Suda T. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med. 12 (2006) 446-451
-
(2006)
Nat. Med.
, vol.12
, pp. 446-451
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Takubo, K.4
Matsuoka, S.5
Miyamoto, K.6
Ohmura, M.7
Naka, K.8
Hosokawa, K.9
Ikeda, Y.10
Suda, T.11
-
33
-
-
0345932931
-
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
-
Iwasa H., Han J., and Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8 (2003) 131-144
-
(2003)
Genes Cells
, vol.8
, pp. 131-144
-
-
Iwasa, H.1
Han, J.2
Ishikawa, F.3
-
34
-
-
11144268164
-
Significant role for p16INK4a in p53-independent telomere-directed senescence
-
Jacobs J.J., and de Lange T. Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr. Biol. 14 (2004) 2302-2308
-
(2004)
Curr. Biol.
, vol.14
, pp. 2302-2308
-
-
Jacobs, J.J.1
de Lange, T.2
-
35
-
-
0033552813
-
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
-
Jacobs J.J., Kieboom K., Marino S., DePinho R.A., and van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397 (1999) 164-168
-
(1999)
Nature
, vol.397
, pp. 164-168
-
-
Jacobs, J.J.1
Kieboom, K.2
Marino, S.3
DePinho, R.A.4
van Lohuizen, M.5
-
36
-
-
0033764030
-
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
-
Jacobs J.J., Keblusek P., Robanus-Maandag E., Kristel P., Lingbeek M., Nederlof P.M., van Welsem T., van de Vijver M.J., Koh E.Y., Daley G.Q., and van Lohuizen M. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nat. Genet. 26 (2000) 291-299
-
(2000)
Nat. Genet.
, vol.26
, pp. 291-299
-
-
Jacobs, J.J.1
Keblusek, P.2
Robanus-Maandag, E.3
Kristel, P.4
Lingbeek, M.5
Nederlof, P.M.6
van Welsem, T.7
van de Vijver, M.J.8
Koh, E.Y.9
Daley, G.Q.10
van Lohuizen, M.11
-
37
-
-
33749172559
-
Stem cell aging modified by the cyclin dependent kinase inhibitor, p16INK4a
-
Janzen V., Forkert R., Fleming H., Saito Y., Waring M., Dombkowski D., Cheng T., DePinho R., Sharpless N., and Scadden D. Stem cell aging modified by the cyclin dependent kinase inhibitor, p16INK4a. Nature 443 (2006) 421-426
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.3
Saito, Y.4
Waring, M.5
Dombkowski, D.6
Cheng, T.7
DePinho, R.8
Sharpless, N.9
Scadden, D.10
-
38
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo T., Zindy F., Roussel M.F., Quelle D.E., Downing J.R., Ashmun R.A., Grosveld G., and Sherr C.J. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91 (1997) 649-659
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
39
-
-
4544242851
-
Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
-
Kawasaki H., and Taira K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 431 (2004) 211-217
-
(2004)
Nature
, vol.431
, pp. 211-217
-
-
Kawasaki, H.1
Taira, K.2
-
40
-
-
0036133108
-
ARF function does not require p53 stabilization or Mdm2 relocalization
-
Korgaonkar C., Zhao L., Modestou M., and Quelle D.E. ARF function does not require p53 stabilization or Mdm2 relocalization. Mol. Cell. Biol. 22 (2002) 196-206
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 196-206
-
-
Korgaonkar, C.1
Zhao, L.2
Modestou, M.3
Quelle, D.E.4
-
41
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J., Torrice C., Ramsey M.R., Kovalev G.I., Al-Regaiey K., Su L., and Sharpless N.E. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114 (2004) 1299-1307
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
42
-
-
33749187810
-
p16INK4a induces an age-dependent decline in islet regenerative potential
-
Krishnamurthy J., Ramsey M., Ligon K., Torrice C., Koh A., Bonner-Weir S., and Sharpless N. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 (2006) 453-457
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.2
Ligon, K.3
Torrice, C.4
Koh, A.5
Bonner-Weir, S.6
Sharpless, N.7
-
43
-
-
3543148255
-
N-terminal polyubiquitination and degradation of the Arf tumor suppressor
-
Kuo M.L., den Besten W., Bertwistle D., Roussel M.F., and Sherr C.J. N-terminal polyubiquitination and degradation of the Arf tumor suppressor. Genes Dev. 18 (2004) 1862-1874
-
(2004)
Genes Dev.
, vol.18
, pp. 1862-1874
-
-
Kuo, M.L.1
den Besten, W.2
Bertwistle, D.3
Roussel, M.F.4
Sherr, C.J.5
-
44
-
-
0034600841
-
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis
-
Latres E., Malumbres M., Sotillo R., Martin J., Ortega S., Martin-Caballero J., Flores J.M., Cordon-Cardo C., and Barbacid M. Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 19 (2000) 3496-3506
-
(2000)
EMBO J.
, vol.19
, pp. 3496-3506
-
-
Latres, E.1
Malumbres, M.2
Sotillo, R.3
Martin, J.4
Ortega, S.5
Martin-Caballero, J.6
Flores, J.M.7
Cordon-Cardo, C.8
Barbacid, M.9
-
46
-
-
8644284936
-
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
-
Matheu A., Pantoja C., Efeyan A., Criado L.M., Martin-Caballero J., Flores J.M., Klatt P., and Serrano M. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev. 18 (2004) 2736-2746
-
(2004)
Genes Dev.
, vol.18
, pp. 2736-2746
-
-
Matheu, A.1
Pantoja, C.2
Efeyan, A.3
Criado, L.M.4
Martin-Caballero, J.5
Flores, J.M.6
Klatt, P.7
Serrano, M.8
-
47
-
-
33747625689
-
Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress
-
Matthews C., Gorenne I., Scott S., Figg N., Kirkpatrick P., Ritchie A., Goddard M., and Bennett M. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. Circ. Res. 99 (2006) 156-164
-
(2006)
Circ. Res.
, vol.99
, pp. 156-164
-
-
Matthews, C.1
Gorenne, I.2
Scott, S.3
Figg, N.4
Kirkpatrick, P.5
Ritchie, A.6
Goddard, M.7
Bennett, M.8
-
48
-
-
33644979481
-
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells
-
10.1371/journal.pbio.0040051
-
McDermott K.M., Zhang J., Holst C.R., Kozakiewicz B.K., Singla V., and Tlsty T.D. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol. 4 (2006) e51 10.1371/journal.pbio.0040051
-
(2006)
PLoS Biol.
, vol.4
-
-
McDermott, K.M.1
Zhang, J.2
Holst, C.R.3
Kozakiewicz, B.K.4
Singla, V.5
Tlsty, T.D.6
-
49
-
-
0037133685
-
The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development
-
McKeller R.N., Fowler J.L., Cunningham J.J., Warner N., Smeyne R.J., Zindy F., and Skapek S.X. The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development. Proc. Natl. Acad. Sci. USA 99 (2002) 3848-3853
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3848-3853
-
-
McKeller, R.N.1
Fowler, J.L.2
Cunningham, J.J.3
Warner, N.4
Smeyne, R.J.5
Zindy, F.6
Skapek, S.X.7
-
50
-
-
0037850928
-
Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
-
Melk A., Kittikowit W., Sandhu I., Halloran K.M., Grimm P., Schmidt B.M., and Halloran P.F. Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int. 63 (2003) 2134-2143
-
(2003)
Kidney Int.
, vol.63
, pp. 2134-2143
-
-
Melk, A.1
Kittikowit, W.2
Sandhu, I.3
Halloran, K.M.4
Grimm, P.5
Schmidt, B.M.6
Halloran, P.F.7
-
51
-
-
1642561702
-
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
-
Melk A., Schmidt B.M., Takeuchi O., Sawitzki B., Rayner D.C., and Halloran P.F. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int. 65 (2004) 510-520
-
(2004)
Kidney Int.
, vol.65
, pp. 510-520
-
-
Melk, A.1
Schmidt, B.M.2
Takeuchi, O.3
Sawitzki, B.4
Rayner, D.C.5
Halloran, P.F.6
-
52
-
-
0141482100
-
Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells
-
Meng A., Wang Y., Van Zant G., and Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res. 63 (2003) 5414-5419
-
(2003)
Cancer Res.
, vol.63
, pp. 5414-5419
-
-
Meng, A.1
Wang, Y.2
Van Zant, G.3
Zhou, D.4
-
53
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C., Vredeveld L.C., Soengas M.S., Denoyelle C., Kuilman T., van der Horst C.M., Majoor D.M., Shay J.W., Mooi W.J., and Peeper D.S. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436 (2005) 720-724
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
van der Horst, C.M.6
Majoor, D.M.7
Shay, J.W.8
Mooi, W.J.9
Peeper, D.S.10
-
54
-
-
0242667922
-
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
-
Molofsky A.V., Pardal R., Iwashita T., Park I.K., Clarke M.F., and Morrison S.J. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425 (2003) 962-967
-
(2003)
Nature
, vol.425
, pp. 962-967
-
-
Molofsky, A.V.1
Pardal, R.2
Iwashita, T.3
Park, I.K.4
Clarke, M.F.5
Morrison, S.J.6
-
55
-
-
22344449361
-
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
-
Molofsky A.V., He S., Bydon M., Morrison S.J., and Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev. 19 (2005) 1432-1437
-
(2005)
Genes Dev.
, vol.19
, pp. 1432-1437
-
-
Molofsky, A.V.1
He, S.2
Bydon, M.3
Morrison, S.J.4
Pardal, R.5
-
56
-
-
33749171885
-
Increasing Ink4a expression reduces forebrain progenitor function and neurogenesis during aging
-
Molofsky A.V., Slutsky S.G., Joseph N.M., He S., Pardal R., Krishnamurthy J., Sharpless N.E., and Morrison S.J. Increasing Ink4a expression reduces forebrain progenitor function and neurogenesis during aging. Nature 443 (2006) 448-452
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
He, S.4
Pardal, R.5
Krishnamurthy, J.6
Sharpless, N.E.7
Morrison, S.J.8
-
57
-
-
4344705410
-
Small interfering RNA-induced transcriptional gene silencing in human cells
-
Morris K.V., Chan S.W., Jacobsen S.E., and Looney D.J. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 305 (2004) 1289-1292
-
(2004)
Science
, vol.305
, pp. 1289-1292
-
-
Morris, K.V.1
Chan, S.W.2
Jacobsen, S.E.3
Looney, D.J.4
-
58
-
-
0029813378
-
The aging of hematopoietic stem cells
-
Morrison S.J., Wandycz A.M., Akashi K., Globerson A., and Weissman I.L. The aging of hematopoietic stem cells. Nat. Med. 9 (1996) 1011-1016
-
(1996)
Nat. Med.
, vol.9
, pp. 1011-1016
-
-
Morrison, S.J.1
Wandycz, A.M.2
Akashi, K.3
Globerson, A.4
Weissman, I.L.5
-
59
-
-
0033152226
-
Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization
-
Munro J., Stott F.J., Vousden K.H., Peters G., and Parkinson E.K. Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization. Cancer Res. 59 (1999) 2516-2521
-
(1999)
Cancer Res.
, vol.59
, pp. 2516-2521
-
-
Munro, J.1
Stott, F.J.2
Vousden, K.H.3
Peters, G.4
Parkinson, E.K.5
-
60
-
-
0029804029
-
A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids
-
Nairn R.S., Kazianis S., McEntire B.B., Della Coletta L., Walter R.B., and Morizot D.C. A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids. Proc. Natl. Acad. Sci. USA 93 (1996) 13042-13047
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13042-13047
-
-
Nairn, R.S.1
Kazianis, S.2
McEntire, B.B.3
Della Coletta, L.4
Walter, R.B.5
Morizot, D.C.6
-
61
-
-
0032589106
-
Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues
-
Nielsen G.P., Stemmer-Rachamimov A.O., Shaw J., Roy J.E., Koh J., and Louis D.N. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab. Invest. 79 (1999) 1137-1143
-
(1999)
Lab. Invest.
, vol.79
, pp. 1137-1143
-
-
Nielsen, G.P.1
Stemmer-Rachamimov, A.O.2
Shaw, J.3
Roy, J.E.4
Koh, J.5
Louis, D.N.6
-
62
-
-
0035931859
-
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
-
Ohtani N., Zebedee Z., Huot T.J., Stinson J.A., Sugimoto M., Ohashi Y., Sharrocks A.D., Peters G., and Hara E. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409 (2001) 1067-1070
-
(2001)
Nature
, vol.409
, pp. 1067-1070
-
-
Ohtani, N.1
Zebedee, Z.2
Huot, T.J.3
Stinson, J.A.4
Sugimoto, M.5
Ohashi, Y.6
Sharrocks, A.D.7
Peters, G.8
Hara, E.9
-
63
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
Park I.K., Qian D., Kiel M., Becker M.W., Pihalja M., Weissman I.L., Morrison S.J., and Clarke M.F. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423 (2003) 302-305
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
Becker, M.W.4
Pihalja, M.5
Weissman, I.L.6
Morrison, S.J.7
Clarke, M.F.8
-
64
-
-
0033200066
-
Ultraviolet radiation induces p16CDKN2A expression in human skin
-
Pavey S., Conroy S., Russell T., and Gabrielli B. Ultraviolet radiation induces p16CDKN2A expression in human skin. Cancer Res. 59 (1999) 4185-4189
-
(1999)
Cancer Res.
, vol.59
, pp. 4185-4189
-
-
Pavey, S.1
Conroy, S.2
Russell, T.3
Gabrielli, B.4
-
65
-
-
0034122707
-
The expression of p16(INK4a), the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation
-
Piepkorn M. The expression of p16(INK4a), the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation. J. Am. Acad. Dermatol. 42 (2000) 741-745
-
(2000)
J. Am. Acad. Dermatol.
, vol.42
, pp. 741-745
-
-
Piepkorn, M.1
-
66
-
-
0035170850
-
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family
-
Randerson-Moor J.A., Harland M., Williams S., Cuthbert-Heavens D., Sheridan E., Aveyard J., Sibley K., Whitaker L., Knowles M., Newton Bishop J., and Bishop D.T. A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family. Hum. Mol. Genet. 10 (2001) 55-62
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 55-62
-
-
Randerson-Moor, J.A.1
Harland, M.2
Williams, S.3
Cuthbert-Heavens, D.4
Sheridan, E.5
Aveyard, J.6
Sibley, K.7
Whitaker, L.8
Knowles, M.9
Newton Bishop, J.10
Bishop, D.T.11
-
67
-
-
0029153609
-
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
-
Reynisdottir I., Polyak K., Iavarone A., and Massague J. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9 (1995) 1831-1845
-
(1995)
Genes Dev.
, vol.9
, pp. 1831-1845
-
-
Reynisdottir, I.1
Polyak, K.2
Iavarone, A.3
Massague, J.4
-
68
-
-
0035817722
-
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF
-
Rizos H., Puig S., Badenas C., Malvehy J., Darmanian A.P., Jimenez L., Mila M., and Kefford R.F. A melanoma-associated germline mutation in exon 1beta inactivates p14ARF. Oncogene 20 (2001) 5543-5547
-
(2001)
Oncogene
, vol.20
, pp. 5543-5547
-
-
Rizos, H.1
Puig, S.2
Badenas, C.3
Malvehy, J.4
Darmanian, A.P.5
Jimenez, L.6
Mila, M.7
Kefford, R.F.8
-
69
-
-
0032485213
-
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
-
Robles S.J., and Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16 (1998) 1113-1123
-
(1998)
Oncogene
, vol.16
, pp. 1113-1123
-
-
Robles, S.J.1
Adami, G.R.2
-
70
-
-
0033637086
-
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
-
Sage J., Mulligan G.J., Attardi L.D., Miller A., Chen S., Williams B., Theodorou E., and Jacks T. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev. 14 (2000) 3037-3050
-
(2000)
Genes Dev.
, vol.14
, pp. 3037-3050
-
-
Sage, J.1
Mulligan, G.J.2
Attardi, L.D.3
Miller, A.4
Chen, S.5
Williams, B.6
Theodorou, E.7
Jacks, T.8
-
71
-
-
2942529456
-
Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling
-
Satyanarayana A., Greenberg R.A., Schaetzlein S., Buer J., Masutomi K., Hahn W.C., Zimmermann S., Martens U., Manns M.P., and Rudolph K.L. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol. Cell. Biol. 24 (2004) 5459-5474
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5459-5474
-
-
Satyanarayana, A.1
Greenberg, R.A.2
Schaetzlein, S.3
Buer, J.4
Masutomi, K.5
Hahn, W.C.6
Zimmermann, S.7
Martens, U.8
Manns, M.P.9
Rudolph, K.L.10
-
72
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M., Lin A.W., McCurrach M.E., Beach D., and Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 (1997) 593-602
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
73
-
-
22144489899
-
INK4a/ARF: a multifunctional tumor suppressor locus
-
Sharpless N.E. INK4a/ARF: a multifunctional tumor suppressor locus. Mutat. Res. 576 (2005) 22-38
-
(2005)
Mutat. Res.
, vol.576
, pp. 22-38
-
-
Sharpless, N.E.1
-
74
-
-
0842265035
-
The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis
-
Sharpless N.E., Ramsey M.R., Balasubramanian P., Castrillon D.H., and DePinho R.A. The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene 23 (2004) 379-385
-
(2004)
Oncogene
, vol.23
, pp. 379-385
-
-
Sharpless, N.E.1
Ramsey, M.R.2
Balasubramanian, P.3
Castrillon, D.H.4
DePinho, R.A.5
-
75
-
-
0034660892
-
The Pezcoller lecture: cancer cell cycles revisited
-
Sherr C.J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 60 (2000) 3689-3695
-
(2000)
Cancer Res.
, vol.60
, pp. 3689-3695
-
-
Sherr, C.J.1
-
76
-
-
11144256284
-
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor
-
Sreeramaneni R., Chaudhry A., McMahon M., Sherr C.J., and Inoue K. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Mol. Cell. Biol. 25 (2005) 220-232
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 220-232
-
-
Sreeramaneni, R.1
Chaudhry, A.2
McMahon, M.3
Sherr, C.J.4
Inoue, K.5
-
77
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein G.H., Drullinger L.F., Soulard A., and Dulic V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 19 (1999) 2109-2117
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
78
-
-
23044461852
-
A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
-
Stepanova L., and Sorrentino B.P. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood 106 (2005) 827-832
-
(2005)
Blood
, vol.106
, pp. 827-832
-
-
Stepanova, L.1
Sorrentino, B.P.2
-
79
-
-
33744988093
-
Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts
-
Stockl P., Hutter E., Zwerschke W., and Jansen-Durr P. Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts. Exp. Gerontol. 41 (2006) 674-682
-
(2006)
Exp. Gerontol.
, vol.41
, pp. 674-682
-
-
Stockl, P.1
Hutter, E.2
Zwerschke, W.3
Jansen-Durr, P.4
-
80
-
-
0030612423
-
Hypermethylation of the p15INK4B gene in myelodysplastic syndromes
-
Uchida T., Kinoshita T., Nagai H., Nakahara Y., Saito H., Hotta T., and Murate T. Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood 90 (1997) 1403-1409
-
(1997)
Blood
, vol.90
, pp. 1403-1409
-
-
Uchida, T.1
Kinoshita, T.2
Nagai, H.3
Nakahara, Y.4
Saito, H.5
Hotta, T.6
Murate, T.7
-
81
-
-
30144439380
-
Total body irradiation selectively induces murine hematopoietic stem cell senescence
-
Wang Y., Schulte B.A., Larue A.C., Ogawa M., and Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 107 (2006) 358-366
-
(2006)
Blood
, vol.107
, pp. 358-366
-
-
Wang, Y.1
Schulte, B.A.2
Larue, A.C.3
Ogawa, M.4
Zhou, D.5
-
82
-
-
0034665749
-
p53-independent functions of the p19(ARF) tumor suppressor
-
Weber J.D., Jeffers J.R., Rehg J.E., Randle D.H., Lozano G., Roussel M.F., Sherr C.J., and Zambetti G.P. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev. 14 (2000) 2358-2365
-
(2000)
Genes Dev.
, vol.14
, pp. 2358-2365
-
-
Weber, J.D.1
Jeffers, J.R.2
Rehg, J.E.3
Randle, D.H.4
Lozano, G.5
Roussel, M.F.6
Sherr, C.J.7
Zambetti, G.P.8
-
83
-
-
0030612349
-
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
-
Zindy F., Quelle D.E., Roussel M.F., and Sherr C.J. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15 (1997) 203-211
-
(1997)
Oncogene
, vol.15
, pp. 203-211
-
-
Zindy, F.1
Quelle, D.E.2
Roussel, M.F.3
Sherr, C.J.4
|