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Volumn 404, Issue 6777, 2000, Pages 510-514

Dna repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; ARTICLE; CANCER SUSCEPTIBILITY; CELL VIABILITY; CHROMOSOME ABERRATION; DNA REPAIR; DNA STRAND BREAKAGE; GENE REARRANGEMENT; GENE TARGETING; IONIZING RADIATION; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL;

EID: 0034732239     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35006670     Document Type: Article
Times cited : (483)

References (30)
  • 1
    • 0030932869 scopus 로고    scopus 로고
    • Gatekeepers and caretakers
    • Kinzler, K. W. & Vogelstein, B. Gatekeepers and caretakers. Nature 386, 761-763 (1997).
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 3
    • 0029778191 scopus 로고    scopus 로고
    • Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
    • Nussenzweig, A. et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382, 551-555 (1996).
    • (1996) Nature , vol.382 , pp. 551-555
    • Nussenzweig, A.1
  • 4
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu, C., Bogue, M. A., Lim, D. S., Hasty, P. & Roth, D. B. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86, 379-389 (1996).
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 5
    • 0030885974 scopus 로고    scopus 로고
    • Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo
    • Ouyang, H. et al. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo. J. Exp. Med. 186, 921-929 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 921-929
    • Ouyang, H.1
  • 6
    • 0031433517 scopus 로고    scopus 로고
    • Growth retardation and leaky SCID phenotype of Ku70-deficient mice
    • Gu, Y. et al. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 367-376 (1997).
    • (1997) Immunity , vol.7 , pp. 367-376
    • Gu, Y.1
  • 7
    • 0032417640 scopus 로고    scopus 로고
    • A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
    • Gao, Y. et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95, 891-902 (1998).
    • (1998) Cell , vol.95 , pp. 891-902
    • Gao, Y.1
  • 8
    • 0032511976 scopus 로고    scopus 로고
    • Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
    • Frank, K. M. et al. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173-177 (1998).
    • (1998) Nature , vol.396 , pp. 173-177
    • Frank, K.M.1
  • 9
    • 0032585526 scopus 로고    scopus 로고
    • Targeted disruption of the gene encoding DNA Iigase IV leads to lethality in embryonic mice
    • Barnes, D. E., Stamp, G., Rosewell, I., Denzel, A. & Lindahl, T. Targeted disruption of the gene encoding DNA Iigase IV leads to lethality in embryonic mice. Curr. Biol. 8, 1395-1398 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 1395-1398
    • Barnes, D.E.1    Stamp, G.2    Rosewell, I.3    Denzel, A.4    Lindahl, T.5
  • 10
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell 88, 323-331 (1997).
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 11
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7 (1994).
    • (1994) Curr. Biol. , vol.4 , pp. 1-7
    • Jacks, T.1
  • 12
    • 16144368671 scopus 로고    scopus 로고
    • Multicolour spectral karyotyping of mouse chromosomes
    • Liyanage, M. et al. Multicolour spectral karyotyping of mouse chromosomes. Nature Genet. 14, 312-315 (1996).
    • (1996) Nature Genet. , vol.14 , pp. 312-315
    • Liyanage, M.1
  • 13
    • 0001292985 scopus 로고
    • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
    • Taub, R. et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc. Natl Acad. Sci. USA 79, 7837-7841 (1982).
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 7837-7841
    • Taub, R.1
  • 14
    • 0344541696 scopus 로고    scopus 로고
    • Genetic pathway to recurrent chromsome translocations in murine lymphoma involves V(D)J recombinase
    • Vanasse, G. J. et al. Genetic pathway to recurrent chromsome translocations in murine lymphoma involves V(D)J recombinase. J. Clin. Invest. 103, 1669-1675 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 1669-1675
    • Vanasse, G.J.1
  • 15
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • Gao, Y. et al. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9, 367-376 (1998).
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1
  • 16
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643-649 (1998).
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 17
    • 0033576687 scopus 로고    scopus 로고
    • The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
    • Katanjawala, Z. E., Grawunder, U., Hsieh, C. L. & Lieber, M. R. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr. Biol. 9, 1501-1504 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 1501-1504
    • Katanjawala, Z.E.1    Grawunder, U.2    Hsieh, C.L.3    Lieber, M.R.4
  • 18
  • 19
    • 0033106326 scopus 로고    scopus 로고
    • Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • Xu, X. et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3, 389-395 (1999).
    • (1999) Mol. Cell , vol.3 , pp. 389-395
    • Xu, X.1
  • 20
    • 0032551829 scopus 로고    scopus 로고
    • Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    • Agrawal, A., Eastman, Q. M. & Schatz, D. G. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394, 744-751 (1998).
    • (1998) Nature , vol.394 , pp. 744-751
    • Agrawal, A.1    Eastman, Q.M.2    Schatz, D.G.3
  • 21
    • 0032555758 scopus 로고    scopus 로고
    • DNA transposition by the Rag1 and Rag2 proteins: A possible source of oncogenic translocations
    • Hiom, K., Melek, M. & Gellert, M. DNA transposition by the Rag1 and Rag2 proteins: a possible source of oncogenic translocations. Cell 94, 463-470 (1998).
    • (1998) Cell , vol.94 , pp. 463-470
    • Hiom, K.1    Melek, M.2    Gellert, M.3
  • 22
    • 0032518680 scopus 로고    scopus 로고
    • Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
    • Ramsden, D. A. & Gellert, M. Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J 17, 609-614 (1998).
    • (1998) EMBO J , vol.17 , pp. 609-614
    • Ramsden, D.A.1    Gellert, M.2
  • 23
    • 0033560796 scopus 로고    scopus 로고
    • The DMA-dependent protein kinase
    • Smith, G. C. M. & Jackson, S. P. The DMA-dependent protein kinase. Genes Dev. 13, 916-934 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 916-934
    • Smith, G.C.M.1    Jackson, S.P.2
  • 24
    • 0032109778 scopus 로고    scopus 로고
    • Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair
    • Chen, C., Umezu, K. & Kolodner, R. D. Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol. Cell 2, 9-22 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 9-22
    • Chen, C.1    Umezu, K.2    Kolodner, R.D.3
  • 25
  • 26
    • 0033598437 scopus 로고    scopus 로고
    • Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    • Johnson, R. D., Liu, N. & Jasin, M. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature 401, 397-399 (1999).
    • (1999) Nature , vol.401 , pp. 397-399
    • Johnson, R.D.1    Liu, N.2    Jasin, M.3
  • 27
    • 0027981995 scopus 로고
    • Rapid allelotype analysis of p53 knockout mice
    • Timme, T. L. & Thompson, T. C. Rapid allelotype analysis of p53 knockout mice. Biotechniques 17, 462-463 (1994).
    • (1994) Biotechniques , vol.17 , pp. 462-463
    • Timme, T.L.1    Thompson, T.C.2
  • 28
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221 (1992).
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 29
    • 0033989262 scopus 로고    scopus 로고
    • Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations
    • Ghadimi, B. M. et al. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer 27, 183-190 (2000).
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 183-190
    • Ghadimi, B.M.1
  • 30
    • 0026636784 scopus 로고
    • Quantitation of immunoglobulin μ-γ1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method
    • Chu, C. C., Paul, W. E. & Max, E. E. Quantitation of immunoglobulin μ-γ1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc. Natl Acad. Sci. USA 89, 6978-6982 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 6978-6982
    • Chu, C.C.1    Paul, W.E.2    Max, E.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.