C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span

Cell

Volumn 125, Issue 6, 2006, Pages 1165-1177

  Berdichevsky, Ala ^a   Viswanathan, Mohan ^a   Horvitz, H Robert ^a   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN 14 3 3; SILENT INFORMATION REGULATOR PROTEIN 2; TRANSCRIPTION FACTOR DAF 16;

ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENETIC REGULATION; HEAT STRESS; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

CAENORHABDITIS ELEGANS;

EID: 33744976074     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.04.036     Document Type: Article

References (58)

1. Blander G., and Guarente L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73 (2004) 417-435
2. Bouras T., Fu M., Sauve A.A., Wang F., Quong A.A., Perkins N.D., Hay R.T., Gu W., and Pestell R.G. SIRT1 deacetylation and repression of P300 involves lysine residues 1020/1024 within the cell-cycle regulatory domain 1. J. Biol. Chem. 280 (2005) 10264-10276
3. Brenner S. The genetics of Caenorhabditis elegans. Genetics 77 (1974) 71-94
4. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., and Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 (1999) 857-868
5. Brunet A., Kanai F., Stehn J., Xu J., Sarbassova D., Frangioni J.V., Dalal S.N., DeCaprio J.A., Greenberg M.E., and Yaffe M.B. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J. Cell Biol. 156 (2002) 817-828
6. Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
7. Cahill C.M., Tzivion G., Nasrin N., Ogg S., Dore J., Ruvkun G., and Alexander-Bridges M. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J. Biol. Chem. 276 (2001) 13402-13410
8. Chen F., Hersh B.M., Conradt B., Zhou Z., Riemer D., Gruenbaum Y., and Horvitz H.R. Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science 287 (2000) 1485-1489
9. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., and Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (2004) 390-392
10. Durocher D., Taylor I.A., Sarbassova D., Haire L.F., Westcott S.L., Jackson S.P., Smerdon S.J., and Yaffe M.B. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6 (2000) 1169-1182
11. Essers M.A., Weijzen S., de Vries-Smits A.M., Saarloos I., de Ruiter N.D., Bos J.L., and Burgering B.M. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23 (2004) 4802-4812
12. Essers M.A., de Vries-Smits L.M., Barker N., Polderman P.E., Burgering B.M., and Korswagen H.C. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 (2005) 1181-1184
13. Finch C.E., and Ruvkun G. The genetics of aging. Annu. Rev. Genomics Hum. Genet. 2 (2001) 435-462
14. Finney M., and Ruvkun G. The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63 (1990) 895-905
15. Guarente L., and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 408 (2000) 255-262
16. Henderson S.T., and Johnson T.E. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 (2001) 1975-1980
17. Honda Y., and Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13 (1999) 1385-1393
18. Hsu A.L., Murphy C.T., and Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300 (2003) 1142-1145
19. Hwang H.Y., and Horvitz H.R. The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Proc. Natl. Acad. Sci. USA 99 (2002) 14224-14229
20. Jansen G., Hazendonk E., Thijssen K.L., and Plasterk R.H. Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Nat. Genet. 17 (1997) 119-121
21. Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
22. Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M., Kanapin A., Le Bot N., Moreno S., Sohrmann M., et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421 (2003) 231-237
23. Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 120 (2005) 449-460
24. Lamitina S.T., and Strange K. Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Am. J. Physiol. Cell Physiol. 288 (2005) C467-C474
25. Langley E., Pearson M., Faretta M., Bauer U.M., Frye R.A., Minucci S., Pelicci P.G., and Kouzarides T. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21 (2002) 2383-2396
26. Larsen P.L., Albert P.S., and Riddle D.L. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139 (1995) 1567-1583
27. Lee R.Y., Hench J., and Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11 (2001) 1950-1957
28. Lee S.S., Kennedy S., Tolonen A.C., and Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 300 (2003) 644-647
29. Libina N., Berman J.R., and Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115 (2003) 489-502
30. Lin K., Dorman J.B., Rodan A., and Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278 (1997) 1319-1322
31. Lin K., Hsin H., Libina N., and Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28 (2001) 139-145
32. Liu L.X., Spoerke J.M., Mulligan E.L., Chen J., Reardon B., Westlund B., Sun L., Abel K., Armstrong B., Hardiman G., et al. High-throughput isolation of Caenorhabditis elegans deletion mutants. Genome Res. 9 (1999) 859-867
33. Liu J., Rolef Ben-Shahar T., Riemer D., Treinin M., Spann P., Weber K., Fire A., and Gruenbaum Y. Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol. Biol. Cell 11 (2000) 3937-3947
34. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
35. McElwee J., Bubb K., and Thomas J.H. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2 (2003) 111-121
36. Morton D.G., Shakes D.C., Nugent S., Dichoso D., Wang W., Golden A., and Kemphues K.J. The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Dev. Biol. 241 (2002) 47-58
37. Motta M.C., Divecha N., Lemieux M., Kamel C., Chen D., Gu W., Bultsma Y., McBurney M., and Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell 116 (2004) 551-563
38. Murakami S., and Johnson T.E. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143 (1996) 1207-1218
39. Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., Li H., and Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 (2003) 277-283
40. Nakae J., Park B.C., and Accili D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J. Biol. Chem. 274 (1999) 15982-15985
41. Obsil T., Ghirlando R., Anderson D.E., Hickman A.B., and Dyda F. Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry 42 (2003) 15264-15272
42. Oh S.W., Mukhopadhyay A., Svrzikapa N., Jiang F., Davis R.J., and Tissenbaum H.A. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. USA 102 (2005) 4494-4499
43. Paradis S., and Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12 (1998) 2488-2498
44. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., and Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (2004) 771-776
45. Rogina B., and Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. USA 101 (2004) 15998-16003
46. Takata T., and Ishikawa F. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 301 (2003) 250-257
47. Tang E.D., Nunez G., Barr F.G., and Guan K.L. Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274 (1999) 16741-16746
48. Timmons L., Court D.L., and Fire A. Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263 (2001) 103-112
49. Tissenbaum H.A., and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410 (2001) 227-230
50. Tran H., Brunet A., Griffith E.C., and Greenberg M.E. The many forks in FOXO's road. Sci. STKE 2003 (2003) RE5
51. Tzivion G., Shen Y.H., and Zhu J. 14-3-3 proteins; bringing new definitions to scaffolding. Oncogene 20 (2001) 6331-6338
52. Van Der Heide L.P., Hoekman M.F., and Smidt M.P. The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem. J. 380 (2004) 297-309
53. van der Horst A., Tertoolen L.G., de Vries-Smits L.M., Frye R.A., Medema R.H., and Burgering B.M. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J. Biol. Chem. 279 (2004) 28873-28879
54. Vanfleteren J.R., and Braeckman B.P. Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol. Aging 20 (1999) 487-502
55. Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., and Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 (2004) 93-105
56. Viswanathan M., Kim S.K., Berdichevsky A., and Guarente L. A role for sir-2.1 regulation of ER stress response genes in determining C. elegans lifespan. Dev. Cell 9 (2005) 605-615
57. Wang W., and Shakes D.C. Expression patterns and transcript processing of ftt-1 and ftt-2, two C. elegans 14-3-3 homologues. J. Mol. Biol. 268 (1997) 619-630
58. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., and Mayo M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23 (2004) 2369-2380