DNA repair is limiting for haematopoietic stem cells during ageing

Nature

Volumn 447, Issue 7145, 2007, Pages 686-690

  Nijnik, Anastasia ^a   Woodbine, Lisa ^b   Marchetti, Caterina ^b,c   Dawson, Sara ^d   Lambe, Teresa ^a   Liu, Cong ^b   Rodrigues, Neil P ^e   Crockford, Tanya L ^a   Cabuy, Erik ^f   Vindigni, Alessandro ^c   Enver, Tariq ^e   Bell, John I ^a   Slijepcevic, Predrag ^f   Goodnow, Christopher C ^d   Jeggo, Penelope A ^b   Cornall, Richard J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^d Biology and Environment   (Australia)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA LIGASE IV; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

DNA; ENZYME ACTIVITY; GENETIC ANALYSIS; GROWTH RESPONSE; MUTATION; PHYSIOLOGY; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL AGING; CELL FUNCTION; CELL LOSS; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO; GROWTH RETARDATION; HEMATOPOIETIC STEM CELL; IMMUNE DEFICIENCY; LIG4 SYNDROME; MOUSE; MUTAGENESIS; NONHUMAN; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; TISSUE CULTURE; TISSUE TRANSPLANTATION;

EID: 34250001450     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05875     Document Type: Article

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