Medecine: Extension of murine life span by overexpression of catalase targeted to mitochondria

Science

Volumn 308, Issue 5730, 2005, Pages 1909-1911

  Schriner, Samuel E ^a,b   Linford, Nancy J ^a   Martin, George M ^a   Treuting, Piper ^a   Ogburn, Charles E ^a   Emond, Mary ^a   Coskun, Pinar E ^b   Ladiges, Warren ^a   Wolf, Norman ^a   Van Remmen, Holly ^c   Wallace, Douglas C ^b   Rabinovitch, Peter S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of Texas Health Science Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING OF MATERIALS; CELLS; FREE RADICALS; HYDROGEN PEROXIDE; OXIDATION; PATHOLOGY;

MITOCHONDRIA; OXIDATIVE DAMAGE; REACTIVE OXYGEN; SPECIES;

ENZYMES;

8 HYDROXYDEOXYGUANOSINE; ACONITATE HYDRATASE; CATALASE; FREE RADICAL; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THIOREDOXIN; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYGUANOSINE; DNA; DRUG DERIVATIVE; SUPEROXIDE DISMUTASE;

MEDICINE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOSYNTHESIS; CATARACT; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME LOCALIZATION; FEMALE; HEART; HEART DISEASE; HISTOPATHOLOGY; HYPOTHESIS; LIFESPAN; LONGEVITY; MALE; MITOCHONDRION; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PEROXISOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; ARTERIOSCLEROSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; HEART MITOCHONDRION; HEART MUSCLE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

ANIMALIA; MAMMALIA; MURINAE; MUS MUSCULUS;

ACONITATE HYDRATASE; AGING; ANIMALS; ARTERIOSCLEROSIS; CATALASE; CATARACT; CELL NUCLEUS; DEOXYGUANOSINE; DNA; FEMALE; FREE RADICALS; HEART DISEASES; HUMANS; HYDROGEN PEROXIDE; LONGEVITY; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIA, HEART; MUSCLE, SKELETAL; MYOCARDIUM; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEROXISOMES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 21144434217     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1106653     Document Type: Article

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22. We thank L. Loeb, B. Preston, and E. Ruiz-Pesini for insightful comments; S. Chen, S. Tsang, S. Knoblaugh, R. Mangalindan, and N. Hudson for technical contributions; and C. Epstein for SOD1-overexpressing animals. Supported by NIH grants AG001751, ES07033, and AG13280.