Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Science

Volumn 316, Issue 5829, 2007, Pages 1331-1336

  Saxena, Richa ^a,b,c   Voight, Benjamin F ^a,b,c   Lyssenko, Valeriya ^d   Burtt, Noël P ^a   De Bakker, Paul I W ^a,b,c   Chen, Hong ^e   Roix, Jeffrey J ^e   Kathiresan, Sekar ^a,b,c   Hirschhorn, Joel N ^a,c,f   Daly, Mark J ^a,b,c   Hughes, Thomas E ^e   Groop, Leif ^d,g   Altshuler, David ^a,b,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

^g HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE REGULATORY PROTEIN; REGULATOR PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

DIABETES; ETIOLOGY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC MARKER; GENOMICS; GLUCOSE; LIPID; MOLECULAR ANALYSIS; PATHOGENICITY; PROTEIN;

ARTICLE; BLOOD PRESSURE; CDKAL1 GENE; CDKN2A GENE; CDKN2B ENE; CONTROLLED STUDY; GENE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC ASSOCIATION; GENOTYPE; GLUCOSE METABOLISM; HHEX GENE; HUMAN; HUMAN GENOME; IGF2BP2 GENE; INTRON; LIPID METABOLISM; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SLC3OA8 GENE; TRIACYLGLYCEROL BLOOD LEVEL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; ALLELES; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 9; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOTYPE; HAPLOTYPES; HUMANS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INTRONS; MALE; META-ANALYSIS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; TRIGLYCERIDES;

EID: 34249888775     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142358     Document Type: Article

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32. We are indebted to all participants in the studies for their support and contributions. This work was supported by Novartis Institutes for BioMedical Research (D.A.), with additional support from The Richard and Susan Smith Family Foundation/American Diabetes Association Pinnacle Program Project Award (D.A., J.N.H., M.J.D.). We thank our colleagues from the UKT2D study and the FUSION study for sharing data before publication and for close and enjoyable collaboration. We thank P. Donnelly for sharing results before publication on behalf of the WTCCC. The following are supported by NIH Research Career Awards: J.C.F. (K23 DK65978-04), H.N.L. [National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K23 DK067288], NIH Research Service Award (R.S.), and a NIH Training grant award (E.K.S.). G.L. is supported by March of Dimes research grant (6-FY04-61). S.K.'s work is supported by grants from the Doris Duke Charitable Foundation, the Fannie E. Rippel Foundation, and NIH (grant K23-HL083102). M.J.D., D.A., S.P., and P.I.W.dB. acknowledge support from NIH/National Heart, Lung, and Blood Institute (grant U01 HG004171). D.A. Is a Burroughs Wellcome Fund Clinical Scholar in Translational Research, and a Distinguished Clinical Scholar of the Doris Duke Charitable Foundation. L.G., T.T., B.I., M.R.T., and the Botnia Study are principally supported by the Sigrid Juselius Foundation, the Finnish Diabetes Research Foundation, The Folkhalsan Research Foundation, and Clinical Research Institute HUCH Ltd; work in Malmō, Sweden, was also funded by a Linné grant from the Swedish Research Council (349-2006-237). We thank H. Hilden, H. Perttunen-Nio, and S. Mahan for technical assistance. We thank the Botnia and Skara research teams for clinical contributions and colleagues at Massachusetts General Hospital, Harvard, Broad, and Novartis for helpful discussions. We thank J. Avruch, M. Fishman, E. Lander, R. Lifton, and E. Scolnick for support and helpful comments on the manuscript.