메뉴 건너뛰기




Volumn 7, Issue 2, 2005, Pages 193-204

Lack of PTEN sequesters CHK1 and initiates genetic instability

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25A; CHECKPOINT KINASE 1; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SERINE; UBIQUITIN; UNCLASSIFIED DRUG;

EID: 13844251972     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2005.01.009     Document Type: Article
Times cited : (292)

References (59)
  • 1
    • 0242266953 scopus 로고    scopus 로고
    • RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development
    • I. Adini, I. Rabinovitz, J.F. Sun, G.C. Prendergast, and L.E. Benjamin RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development Genes Dev. 17 2003 2721 2732
    • (2003) Genes Dev. , vol.17 , pp. 2721-2732
    • Adini, I.1    Rabinovitz, I.2    Sun, J.F.3    Prendergast, G.C.4    Benjamin, L.E.5
  • 4
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • J. Bartek, and J. Lukas Chk1 and Chk2 kinases in checkpoint control and cancer Cancer Cell 3 2003 421 429
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 6
    • 0034636585 scopus 로고    scopus 로고
    • Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation
    • R. Bernardi, D.A. Liebermann, and B. Hoffman Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation Oncogene 19 2000 2447 2454
    • (2000) Oncogene , vol.19 , pp. 2447-2454
    • Bernardi, R.1    Liebermann, D.A.2    Hoffman, B.3
  • 8
    • 0032766844 scopus 로고    scopus 로고
    • Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases
    • I. Blomberg, and I. Hoffmann Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases Mol. Cell. Biol. 19 1999 6183 6194
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6183-6194
    • Blomberg, I.1    Hoffmann, I.2
  • 12
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • L.C. Cantley, and B.G. Neel New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Proc. Natl. Acad. Sci. USA 96 1999 4240 4245
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 13
    • 0142027900 scopus 로고    scopus 로고
    • Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding
    • M.S. Chen, C.E. Ryan, and H. Piwnica-Worms Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding Mol. Cell. Biol. 23 2003 7488 7497
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7488-7497
    • Chen, M.S.1    Ryan, C.E.2    Piwnica-Worms, H.3
  • 14
    • 4043130959 scopus 로고    scopus 로고
    • Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression
    • A.D. Choudhury, H. Xu, and R. Baer Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression J. Biol. Chem. 279 2004 33909 33918
    • (2004) J. Biol. Chem. , vol.279 , pp. 33909-33918
    • Choudhury, A.D.1    Xu, H.2    Baer, R.3
  • 15
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
    • D. Cortez, Y. Wang, J. Qin, and S.J. Elledge Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks Science 286 1999 1162 1166
    • (1999) Science , vol.286 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 16
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • S.J. Elledge Cell cycle checkpoints: Preventing an identity crisis Science 274 1996 1664 1672
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 17
    • 0037047268 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
    • N. Fujita, S. Sato, K. Katayama, and T. Tsuruo Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization J. Biol. Chem. 277 2002 28706 28713
    • (2002) J. Biol. Chem. , vol.277 , pp. 28706-28713
    • Fujita, N.1    Sato, S.2    Katayama, K.3    Tsuruo, T.4
  • 19
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Z. Guo, A. Kumagai, S.X. Wang, and W.G. Dunphy Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts Genes Dev. 14 2000 2745 2756
    • (2000) Genes Dev. , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagai, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 21
    • 0042242580 scopus 로고    scopus 로고
    • Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345
    • K. Jiang, E. Pereira, M. Maxfield, B. Russell, D.M. Goudelock, and Y. Sanchez Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345 J. Biol. Chem. 278 2003 25207 25217
    • (2003) J. Biol. Chem. , vol.278 , pp. 25207-25217
    • Jiang, K.1    Pereira, E.2    Maxfield, M.3    Russell, B.4    Goudelock, D.M.5    Sanchez, Y.6
  • 28
    • 3142552523 scopus 로고    scopus 로고
    • Chk1 is haploinsufficient for multiple functions critical to tumor suppression
    • M.H. Lam, Q. Liu, S.J. Elledge, and J.M. Rosen Chk1 is haploinsufficient for multiple functions critical to tumor suppression Cancer Cell 6 2004 45 59
    • (2004) Cancer Cell , vol.6 , pp. 45-59
    • Lam, M.H.1    Liu, Q.2    Elledge, S.J.3    Rosen, J.M.4
  • 32
    • 0033604468 scopus 로고    scopus 로고
    • The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
    • Y. Lu, Y.Z. Lin, R. LaPushin, B. Cuevas, X. Fang, S.X. Yu, M.A. Davies, H. Khan, T. Furui, and M. Mao The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells Oncogene 18 1999 7034 7045
    • (1999) Oncogene , vol.18 , pp. 7034-7045
    • Lu, Y.1    Lin, Y.Z.2    Lapushin, R.3    Cuevas, B.4    Fang, X.5    Yu, S.X.6    Davies, M.A.7    Khan, H.8    Furui, T.9    Mao, M.10
  • 33
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • T. Maehama, and J.E. Dixon The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J. Biol. Chem. 273 1998 13375 13378
    • (1998) J. Biol. Chem. , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 36
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • L.D. Mayo, and D.B. Donner A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus Proc. Natl. Acad. Sci. USA 98 2001 11598 11603
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 37
    • 0037085271 scopus 로고    scopus 로고
    • PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
    • L.D. Mayo, J.E. Dixon, D.L. Durden, N.K. Tonks, and D.B. Donner PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy J. Biol. Chem. 277 2001 5484 5489
    • (2001) J. Biol. Chem. , vol.277 , pp. 5484-5489
    • Mayo, L.D.1    Dixon, J.E.2    Durden, D.L.3    Tonks, N.K.4    Donner, D.B.5
  • 39
    • 0034941567 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells
    • L. Rossig, A.S. Jadidi, C. Urbich, C. Badorff, A.M. Zeiher, and S. Dimmeler Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells Mol. Cell. Biol. 21 2001 5644 5657
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5644-5657
    • Rossig, L.1    Jadidi, A.S.2    Urbich, C.3    Badorff, C.4    Zeiher, A.M.5    Dimmeler, S.6
  • 42
    • 0036799377 scopus 로고    scopus 로고
    • PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
    • I. Shin, F.M. Yakes, F. Rojo, N.Y. Shin, A.V. Bakin, J. Baselga, and C.L. Arteaga PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization Nat. Med. 8 2002 1145 1152
    • (2002) Nat. Med. , vol.8 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.Y.4    Bakin, A.V.5    Baselga, J.6    Arteaga, C.L.7
  • 43
    • 0037018847 scopus 로고    scopus 로고
    • A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
    • E. Shtivelman, J. Sussman, and D. Stokoe A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle Curr. Biol. 12 2002 919 924
    • (2002) Curr. Biol. , vol.12 , pp. 919-924
    • Shtivelman, E.1    Sussman, J.2    Stokoe, D.3
  • 45
    • 0012966157 scopus 로고    scopus 로고
    • Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    • C.S. Sorensen, R.G. Syljuasen, J. Falck, T. Schroeder, L. Ronnstrand, K.K. Khanna, B.B. Zhou, J. Bartek, and J. Lukas Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A Cancer Cell 3 2003 247 258
    • (2003) Cancer Cell , vol.3 , pp. 247-258
    • Sorensen, C.S.1    Syljuasen, R.G.2    Falck, J.3    Schroeder, T.4    Ronnstrand, L.5    Khanna, K.K.6    Zhou, B.B.7    Bartek, J.8    Lukas, J.9
  • 46
    • 0033575920 scopus 로고    scopus 로고
    • Deregulated cyclin e induces chromosome instability
    • C.H. Spruck, K.A. Won, and S.I. Reed Deregulated cyclin E induces chromosome instability Nature 401 1999 297 300
    • (1999) Nature , vol.401 , pp. 297-300
    • Spruck, C.H.1    Won, K.A.2    Reed, S.I.3
  • 49
    • 0142011466 scopus 로고    scopus 로고
    • PTEN: From pathology to biology
    • M.L. Sulis, and R. Parsons PTEN: From pathology to biology Trends Cell Biol. 13 2003 478 483
    • (2003) Trends Cell Biol. , vol.13 , pp. 478-483
    • Sulis, M.L.1    Parsons, R.2
  • 55
    • 0036899518 scopus 로고    scopus 로고
    • PTEN and myotubularin phosphatases: From 3-phosphoinositide dephosphorylation to disease. Phosphatase and tensin homolog deleted on chromosome ten
    • M.J. Wishart, and J.E. Dixon PTEN and myotubularin phosphatases: From 3-phosphoinositide dephosphorylation to disease. Phosphatase and tensin homolog deleted on chromosome ten Trends Cell Biol. 12 2002 579 585
    • (2002) Trends Cell Biol. , vol.12 , pp. 579-585
    • Wishart, M.J.1    Dixon, J.E.2
  • 57
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • H. Zhao, and H. Piwnica-Worms ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Mol. Cell. Biol. 21 2001 4129 4139
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 58
    • 0037069326 scopus 로고    scopus 로고
    • Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
    • H. Zhao, J.L. Watkins, and H. Piwnica-Worms Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints Proc. Natl. Acad. Sci. USA 99 2002 14795 14800
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14795-14800
    • Zhao, H.1    Watkins, J.L.2    Piwnica-Worms, H.3
  • 59
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • B.P. Zhou, Y. Liao, W. Xia, Y. Zou, B. Spohn, and M.C. Hung HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation Nat. Cell Biol. 3 2001 973 982
    • (2001) Nat. Cell Biol. , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.