메뉴 건너뛰기




Volumn 86, Issue 1, 2015, Pages 799-845

Comprehensive review in current developments of benzimidazole-based medicinal chemistry

Author keywords

anticancer; antitubercular; benzimidazole; pharmacological activity; synthesis

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ANALGESIC AGENT; ANTHELMINTIC AGENT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTICONVULSIVE AGENT; ANTIDIABETIC AGENT; ANTIFUNGAL AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTILEISHMANIAL AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTIPARASITIC AGENT; ANTIPROTOZOAL AGENT; ANTIULCER AGENT; BENZIMIDAZOLE DERIVATIVE; DIURETIC AGENT; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; INDUCIBLE NITRIC OXIDE SYNTHASE; TUBERCULOSTATIC AGENT; BENZIMIDAZOLE;

EID: 84991200182     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12462     Document Type: Article
Times cited : (235)

References (277)
  • 1
    • 84916083399 scopus 로고
    • Reduction-products of nitracetamide compounds
    • Hobrecker F., (1872) Reduction-products of nitracetamide compounds. Deut Chem Ges Ber; 5: 920-924.
    • (1872) Deut Chem Ges Ber , vol.5 , pp. 920-924
    • Hobrecker, F.1
  • 2
    • 84913968063 scopus 로고
    • Derivatives of diamines
    • Ladenberg A., (1875) Derivatives of diamines. Deut Chem Ges Ber; 8: 677-678.
    • (1875) Deut Chem Ges Ber , vol.8 , pp. 677-678
    • Ladenberg, A.1
  • 3
    • 84914312753 scopus 로고
    • Derivatives of phenylenediamines
    • Wundt E., (1878) Derivatives of phenylenediamines. Deut Chem Ges Ber; 11: 826-830.
    • (1878) Deut Chem Ges Ber , vol.11 , pp. 826-830
    • Wundt, E.1
  • 4
    • 84940448513 scopus 로고
    • U ber die einwirkung des ammoniaks auf glyoxal
    • Debus H., (1858) U ber die einwirkung des ammoniaks auf glyoxal. Justus Liebigs Ann Chem; 107: 199-208.
    • (1858) Justus Liebigs Ann Chem , vol.107 , pp. 199-208
    • Debus, H.1
  • 6
    • 0025355351 scopus 로고
    • The synthesis and chemistry of certain anthelmintic benzimidazoles
    • Townsend L.B., Wise D.S., (1990) The synthesis and chemistry of certain anthelmintic benzimidazoles. Parasitol Today; 6: 107-112.
    • (1990) Parasitol Today , vol.6 , pp. 107-112
    • Townsend, L.B.1    Wise, D.S.2
  • 8
    • 0035945983 scopus 로고    scopus 로고
    • A short synthesis of phenanthro[2,3- d]imidazoles from dehydroabietic acid. Application of the methodology as a convenient route to benzimidazoles
    • Fonseca T., Gigante B., Gilchrist T.L., (2001) A short synthesis of phenanthro[2,3- d]imidazoles from dehydroabietic acid. Application of the methodology as a convenient route to benzimidazoles. Tetrahedron; 57: 1793-1799.
    • (2001) Tetrahedron , vol.57 , pp. 1793-1799
    • Fonseca, T.1    Gigante, B.2    Gilchrist, T.L.3
  • 9
    • 26244450484 scopus 로고    scopus 로고
    • Microwave- assisted synthesis of 1-aryl-1H-indazoles via one-pot two-step Cu-catalyzed intramolecular N-arylation of arylhydrazones
    • Pabba C., Wang H.J., Mulligan S.R., Chen Z.J., Stark T.M., Gregg B.T., (2005) Microwave- assisted synthesis of 1-aryl-1H-indazoles via one-pot two-step Cu-catalyzed intramolecular N-arylation of arylhydrazones. Tetrahedron Lett; 46: 7553-7557.
    • (2005) Tetrahedron Lett , vol.46 , pp. 7553-7557
    • Pabba, C.1    Wang, H.J.2    Mulligan, S.R.3    Chen, Z.J.4    Stark, T.M.5    Gregg, B.T.6
  • 10
    • 0025020286 scopus 로고
    • Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-Intercalating agents which may not act via topoisomerase II
    • Denny W.A., Rewcastle G.W., Baguley B.C., (1990) Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-Intercalating agents which may not act via topoisomerase II. J Med Chem; 33: 814-819.
    • (1990) J Med Chem , vol.33 , pp. 814-819
    • Denny, W.A.1    Rewcastle, G.W.2    Baguley, B.C.3
  • 12
    • 0032499283 scopus 로고    scopus 로고
    • Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(β-D-ribofuranosyl)benzimidazole
    • Porcari A.R., Devivar R.V., Kucera L.S., Drach J.C., Townsend L.B., (1998) Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(β-D-ribofuranosyl)benzimidazole. J Med Chem; 41: 1252-1262.
    • (1998) J Med Chem , vol.41 , pp. 1252-1262
    • Porcari, A.R.1    Devivar, R.V.2    Kucera, L.S.3    Drach, J.C.4    Townsend, L.B.5
  • 13
    • 0032499278 scopus 로고    scopus 로고
    • Design, synthesis, and antiviral activity of r-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl) benzimidazoles
    • Migawa M.T., Girardet J.L., Walker J.A., Koszalka G.W., Chamberlain S.D., Drach J.C., Townsend L.B., (1998) Design, synthesis, and antiviral activity of r-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl) benzimidazoles. J Med Chem; 41: 1242-1251.
    • (1998) J Med Chem , vol.41 , pp. 1242-1251
    • Migawa, M.T.1    Girardet, J.L.2    Walker, J.A.3    Koszalka, G.W.4    Chamberlain, S.D.5    Drach, J.C.6    Townsend, L.B.7
  • 14
    • 0017915202 scopus 로고
    • Halobenzimidazoleribosides and RNA synthesis of cells and viruses: I
    • Tamm I., Sehgal P.B., (1978) Halobenzimidazoleribosides and RNA synthesis of cells and viruses: I. Adv Virus Res; 22: 187-258.
    • (1978) Adv Virus Res , vol.22 , pp. 187-258
    • Tamm, I.1    Sehgal, P.B.2
  • 15
    • 0040482632 scopus 로고
    • Ribonucleic acid synthesis and influenza virus multiplication
    • Tamm I., (1957) Ribonucleic acid synthesis and influenza virus multiplication. Science; 126: 1235-1236.
    • (1957) Science , vol.126 , pp. 1235-1236
    • Tamm, I.1
  • 16
    • 0031463691 scopus 로고    scopus 로고
    • Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-aryl-substituted benzimidazoles
    • Roth M., Morningstar M.L., Boyer P.L., Hughes S.H., BuckheitJr R.W., Michejda C.J., (1997) Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-aryl-substituted benzimidazoles. J Med Chem; 40: 4199-4207.
    • (1997) J Med Chem , vol.40 , pp. 4199-4207
    • Roth, M.1    Morningstar, M.L.2    Boyer, P.L.3    Hughes, S.H.4    Buckheitjr, R.W.5    Michejda, C.J.6
  • 17
    • 0001325629 scopus 로고    scopus 로고
    • Substituted 2,5′-bi-1H-benzimidazoles: Topoisomerase i inhibition and cytotoxicity
    • Kim J.S., Gatto B., Yu C., Liu A., Liu L.F., La Voie E.J., (1996) Substituted 2,5′-bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity. J Med Chem; 39: 992-998.
    • (1996) J Med Chem , vol.39 , pp. 992-998
    • Kim, J.S.1    Gatto, B.2    Yu, C.3    Liu, A.4    Liu, L.F.5    La Voie, E.J.6
  • 19
    • 0030480485 scopus 로고    scopus 로고
    • Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidicheterocycles as novel tetrazolebioisosteres
    • Kohara Y., Kubo K., Imamiya E., Wada T., Naka T., Inada Y., (1996) Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidicheterocycles as novel tetrazolebioisosteres. J Med Chem; 39: 5228-5235.
    • (1996) J Med Chem , vol.39 , pp. 5228-5235
    • Kohara, Y.1    Kubo, K.2    Imamiya, E.3    Wada, T.4    Naka, T.5    Inada, Y.6
  • 22
    • 33947458464 scopus 로고
    • The chemistry of the benzimidazoles
    • Wright J.B., (1951) The chemistry of the benzimidazoles. Chem Rev; 48: 397-541.
    • (1951) Chem Rev , vol.48 , pp. 397-541
    • Wright, J.B.1
  • 23
    • 0016146471 scopus 로고
    • Synthesis, reactions, and spectroscopic properties of benzimidazoles
    • Preston P.N., (1974) Synthesis, reactions, and spectroscopic properties of benzimidazoles. Chem Rev; 74: 279-314.
    • (1974) Chem Rev , vol.74 , pp. 279-314
    • Preston, P.N.1
  • 24
    • 0025486534 scopus 로고
    • The benzimidazole anthelmintic agents-A review
    • McKellar Q.A., Scott E.W., (1990) The benzimidazole anthelmintic agents-A review. J Vet Pharmacol Ther; 13: 223-247.
    • (1990) J Vet Pharmacol Ther , vol.13 , pp. 223-247
    • McKellar, Q.A.1    Scott, E.W.2
  • 25
    • 84867571228 scopus 로고    scopus 로고
    • Benzimidazoles in a wormy world
    • Dubey A.K., Sanyal P.K., (2010) Benzimidazoles in a wormy world. Online Vet J; 5: 63-66.
    • (2010) Online Vet J , vol.5 , pp. 63-66
    • Dubey, A.K.1    Sanyal, P.K.2
  • 26
    • 16444367024 scopus 로고    scopus 로고
    • Imidazole and benzimidazole derivatives as chemotherapeutic agents
    • Boiani M., Gonzalez M., (2005) Imidazole and benzimidazole derivatives as chemotherapeutic agents. Mini Rev Med Chem; 5: 409-424.
    • (2005) Mini Rev Med Chem , vol.5 , pp. 409-424
    • Boiani, M.1    Gonzalez, M.2
  • 27
    • 84867581119 scopus 로고    scopus 로고
    • The therapeutic journey of benzimidazoles. A review
    • Bansal Y., Silakari O., (2012) The therapeutic journey of benzimidazoles. A review. Bioorg Med Chem; 20: 6208-6236.
    • (2012) Bioorg Med Chem , vol.20 , pp. 6208-6236
    • Bansal, Y.1    Silakari, O.2
  • 28
    • 78649319180 scopus 로고    scopus 로고
    • Post Groebkee-Blackburn multicomponent protocol: Synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a] pyrimidine derivatives as potential antimicrobial agents
    • Al-Tel T.H., Al-Qawasmeh R.A., (2010) Post Groebkee-Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a] pyrimidine derivatives as potential antimicrobial agents. Eur J Med Chem; 45: 5848-5855.
    • (2010) Eur J Med Chem , vol.45 , pp. 5848-5855
    • Al-Tel, T.H.1    Al-Qawasmeh, R.A.2
  • 29
    • 77955560154 scopus 로고    scopus 로고
    • Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents
    • Fang B., Zhou C., Rao X., (2010) Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. Eur J Med Chem; 45: 4388-4398.
    • (2010) Eur J Med Chem , vol.45 , pp. 4388-4398
    • Fang, B.1    Zhou, C.2    Rao, X.3
  • 31
    • 84863094776 scopus 로고    scopus 로고
    • Conventional and greener approach for the synthesis of some novel substituted -4-oxothiazolidine and their 5-arylidene derivatives of 2-methyl-benzimidazole:antimicrobial activities
    • Dua R., Sonwane S.K., Srivastava S.K., Srivastava S.D., (2010) Conventional and greener approach for the synthesis of some novel substituted -4-oxothiazolidine and their 5-arylidene derivatives of 2-methyl-benzimidazole:antimicrobial activities. J Chem Pharm Res; 2: 415-423.
    • (2010) J Chem Pharm Res , vol.2 , pp. 415-423
    • Dua, R.1    Sonwane, S.K.2    Srivastava, S.K.3    Srivastava, S.D.4
  • 32
    • 80052022193 scopus 로고    scopus 로고
    • Microwave-assisted synthesis of some new tetrazolo [1,5-a]quinoline-based benzimidazoles catalyzed by p-TsOH and investigation of their antimicrobial activity
    • Mungra D.C., Patel M.P., Patel R.G., (2011) Microwave-assisted synthesis of some new tetrazolo [1,5-a]quinoline-based benzimidazoles catalyzed by p-TsOH and investigation of their antimicrobial activity. Med Chem Res; 20: 782-789.
    • (2011) Med Chem Res , vol.20 , pp. 782-789
    • Mungra, D.C.1    Patel, M.P.2    Patel, R.G.3
  • 33
    • 76149127402 scopus 로고    scopus 로고
    • Synthesis and antifungal activity of novel 2-benzimidazolylimino-5-arylidene-4-thiazolidinones
    • Mobinikhaledi A., Foroughifar N., Kalhor M., Mirabolfathy M., (2010) Synthesis and antifungal activity of novel 2-benzimidazolylimino-5-arylidene-4-thiazolidinones. J Heterocyclic Chem; 47: 77-80.
    • (2010) J Heterocyclic Chem , vol.47 , pp. 77-80
    • Mobinikhaledi, A.1    Foroughifar, N.2    Kalhor, M.3    Mirabolfathy, M.4
  • 34
    • 77954275784 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of some novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines
    • Reddy V.A., Reddy K.R., (2010) Synthesis and antimicrobial activity of some novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines. Chem Pharm Bull; 58: 953-956.
    • (2010) Chem Pharm Bull , vol.58 , pp. 953-956
    • Reddy, V.A.1    Reddy, K.R.2
  • 35
    • 77951833212 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
    • Rohini R., Shanker K., Reddy P.M., Ravinder V., (2010) Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines. J Braz Chem Soc; 21: 2149-2157.
    • (2010) J Braz Chem Soc , vol.21 , pp. 2149-2157
    • Rohini, R.1    Shanker, K.2    Reddy, P.M.3    Ravinder, V.4
  • 36
    • 74549179115 scopus 로고    scopus 로고
    • Microwave assisted, one-pot synthesis of 5-nitro-2-aryl substituted-1H-benzimidazole libraries:screening in vitro for antimicrobial activity
    • Hosamani K.M., Seetharamareddy H.R., Keri R.S., Hanamanthagouda M.S., Moloney M.G., (2009) Microwave assisted, one-pot synthesis of 5-nitro-2-aryl substituted-1H-benzimidazole libraries:screening in vitro for antimicrobial activity. J Enzyme Inhibit Med Chem; 24: 1095-1100.
    • (2009) J Enzyme Inhibit Med Chem , vol.24 , pp. 1095-1100
    • Hosamani, K.M.1    Seetharamareddy, H.R.2    Keri, R.S.3    Hanamanthagouda, M.S.4    Moloney, M.G.5
  • 37
    • 84882613743 scopus 로고    scopus 로고
    • Design and synthesis of positional isomers of 5 and 6-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazolesas possible antimicrobial and antitubercular agents
    • Ranjith P.K., Rajeesh P., Haridas K.R., Susanta N.K., Guru Rowb T.N., Rishikesan R., Kumari N.S., (2013) Design and synthesis of positional isomers of 5 and 6-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazolesas possible antimicrobial and antitubercular agents. Bioorg Med Chem Lett; 23: 5228-5234.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 5228-5234
    • Ranjith, P.K.1    Rajeesh, P.2    Haridas, K.R.3    Susanta, N.K.4    Guru Rowb, T.N.5    Rishikesan, R.6    Kumari, N.S.7
  • 38
    • 84878873180 scopus 로고    scopus 로고
    • Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives
    • Zhou B., Li B., Yi W., Bu X., Mac L., (2013) Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. Bioorg Med Chem Lett; 23: 3759-3763.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 3759-3763
    • Zhou, B.1    Li, B.2    Yi, W.3    Bu, X.4    Mac, L.5
  • 39
    • 84877021791 scopus 로고    scopus 로고
    • Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole
    • Zhang H., Damu G.L.V., Cai G., Zhou C., (2013) Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole. Eur J Med Chem; 64: 329-344.
    • (2013) Eur J Med Chem , vol.64 , pp. 329-344
    • Zhang, H.1    Damu, G.L.V.2    Cai, G.3    Zhou, C.4
  • 40
    • 84855815124 scopus 로고    scopus 로고
    • Anti-microbial benzimidazole derivatives: Synthesis and in vitro biological evaluation
    • Soni L., Narsinghani T., Sethi A., (2012) Anti-microbial benzimidazole derivatives: synthesis and in vitro biological evaluation. Med Chem Res; 21: 4330-4334.
    • (2012) Med Chem Res , vol.21 , pp. 4330-4334
    • Soni, L.1    Narsinghani, T.2    Sethi, A.3
  • 42
    • 84893804470 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of benzo[d]imidazolylchromeno[2,3-d]pyrimidinones
    • Ravindernath A., Srinivas Reddy M., Sunil V., (2014) Synthesis and biological evaluation of benzo[d]imidazolylchromeno[2,3-d]pyrimidinones. Med Chem Res; 23: 759-764.
    • (2014) Med Chem Res , vol.23 , pp. 759-764
    • Ravindernath, A.1    Srinivas Reddy, M.2    Sunil, V.3
  • 43
    • 84866343525 scopus 로고    scopus 로고
    • Antimicrobial screening of novel synthesized benzimidazole nucleus containing 4-oxo-thiazolidine derivatives
    • Desai N.C., Dodiya A.M., Makwana A.H., (2012) Antimicrobial screening of novel synthesized benzimidazole nucleus containing 4-oxo-thiazolidine derivatives. Med Chem Res; 21: 2320-2328.
    • (2012) Med Chem Res , vol.21 , pp. 2320-2328
    • Desai, N.C.1    Dodiya, A.M.2    Makwana, A.H.3
  • 44
    • 79955448608 scopus 로고    scopus 로고
    • Synthesis of 2-mercaptobenzimidazole derivatives as potential anti-microbial and cytotoxic agents
    • Hosamani K.M., Shingalapur R.V., (2011) Synthesis of 2-mercaptobenzimidazole derivatives as potential anti-microbial and cytotoxic agents. Arch Pharm Chem Life Sci; 11: 311-319.
    • (2011) Arch Pharm Chem Life Sci , vol.11 , pp. 311-319
    • Hosamani, K.M.1    Shingalapur, R.V.2
  • 45
    • 77954310776 scopus 로고    scopus 로고
    • Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
    • Özkay Y., Tunal Y., Karaca H., Isbox drawings light down and leftkda I., (2010) Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety. Eur J Med Chem; 45: 3293-3298.
    • (2010) Eur J Med Chem , vol.45 , pp. 3293-3298
    • Özkay, Y.1    Tunal, Y.2    Karaca, H.3    Iskda, I.4
  • 46
    • 84865861881 scopus 로고    scopus 로고
    • Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles
    • Li Y.J., Liu L.J., Jin K., Xu Y.T., Sun S.Q., (2010) Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles. Chinese Chem Lett; 21: 293-296.
    • (2010) Chinese Chem Lett , vol.21 , pp. 293-296
    • Li, Y.J.1    Liu, L.J.2    Jin, K.3    Xu, Y.T.4    Sun, S.Q.5
  • 47
    • 77955387239 scopus 로고    scopus 로고
    • Synthesis and antibacterial activity of some novel 6-(1H-benz[d]imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazepines
    • Reddy V.M., Reddy K.R., (2010) Synthesis and antibacterial activity of some novel 6-(1H-benz[d]imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazepines. Chem Pharm Bull; 58: 1081-1084.
    • (2010) Chem Pharm Bull , vol.58 , pp. 1081-1084
    • Reddy, V.M.1    Reddy, K.R.2
  • 48
    • 67651155775 scopus 로고    scopus 로고
    • Synthesis physicochemical properties and antimicrobial activity of some new benzimidazole derivatives
    • Ansari K.F., Lal C., (2009) Synthesis physicochemical properties and antimicrobial activity of some new benzimidazole derivatives. Eur J Med Chem; 44: 4028-4033.
    • (2009) Eur J Med Chem , vol.44 , pp. 4028-4033
    • Ansari, K.F.1    Lal, C.2
  • 49
    • 70349245437 scopus 로고    scopus 로고
    • Synthesis, characterization, and antimicrobial activities of clubbed [1, 2, 4]-oxadiazoles with fluorobenzimidazoles
    • Jadhav G.R., Shaikh M.U., Kale R.P., Ghawalkar A.R., Gill C.H., (2009) Synthesis, characterization, and antimicrobial activities of clubbed [1, 2, 4]-oxadiazoles with fluorobenzimidazoles. J Heterocyclic Chem; 46: 980-987.
    • (2009) J Heterocyclic Chem , vol.46 , pp. 980-987
    • Jadhav, G.R.1    Shaikh, M.U.2    Kale, R.P.3    Ghawalkar, A.R.4    Gill, C.H.5
  • 51
    • 74249097281 scopus 로고    scopus 로고
    • Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety
    • Ansari K.F., Lal C., (2009) Synthesis and biological activity of some heterocyclic compounds containing benzimidazole and beta-lactam moiety. J Chem Sci; 121: 1017-1025.
    • (2009) J Chem Sci , vol.121 , pp. 1017-1025
    • Ansari, K.F.1    Lal, C.2
  • 52
    • 58549110062 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of some novel 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives
    • Kus C., Sozudonmez F., Altanlar N., (2009) Synthesis and antimicrobial activity of some novel 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives. Arch Pharm Chem Life Sci; 342: 54-60.
    • (2009) Arch Pharm Chem Life Sci , vol.342 , pp. 54-60
    • Kus, C.1    Sozudonmez, F.2    Altanlar, N.3
  • 53
    • 84890308292 scopus 로고    scopus 로고
    • Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl-benzimidazole and benzotriazole derivatives
    • Ochal1 Z., Bretner M., Wolinowska R., Tyski S., (2013) Synthesis and in vitro antibacterial activity of 5-halogenomethylsulfonyl-benzimidazole and benzotriazole derivatives. Med Chem; 9: 1129-1136.
    • (2013) Med Chem , vol.9 , pp. 1129-1136
    • Ochal, Z.1    Bretner, M.2    Wolinowska, R.3    Tyski, S.4
  • 54
    • 84870064229 scopus 로고    scopus 로고
    • Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
    • Kumar N.S., Amandoron E.A., Cherkasov A., Finlay B.B., Gong H., Jackson L., Kaur S., et al,. (2012) Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents. Bioorg Med Chem; 20: 7069-7082.
    • (2012) Bioorg Med Chem , vol.20 , pp. 7069-7082
    • Kumar, N.S.1    Amandoron, E.A.2    Cherkasov, A.3    Finlay, B.B.4    Gong, H.5    Jackson, L.6    Kaur, S.7
  • 55
    • 84897627445 scopus 로고    scopus 로고
    • Synthesis, antimicrobial and cytotoxic activity of novelazetidine-2-one derivatives of 1H-benzimidazole
    • Noolvi M., Agrawal S., Patel H., Badiger A., Gaba M., Zambre A., (2014) Synthesis, antimicrobial and cytotoxic activity of novelazetidine-2-one derivatives of 1H-benzimidazole. Arabian J Chem; 7: 219-226.
    • (2014) Arabian J Chem , vol.7 , pp. 219-226
    • Noolvi, M.1    Agrawal, S.2    Patel, H.3    Badiger, A.4    Gaba, M.5    Zambre, A.6
  • 57
    • 84865760149 scopus 로고    scopus 로고
    • Synthesis and biological Evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin
    • Zhang S., Damu G.L.V., Zhang L., Geng R., Zhou C., (2012) Synthesis and biological Evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin. Eur J Med Chem; 55: 164-175.
    • (2012) Eur J Med Chem , vol.55 , pp. 164-175
    • Zhang, S.1    Damu, G.L.V.2    Zhang, L.3    Geng, R.4    Zhou, C.5
  • 58
    • 84875234383 scopus 로고    scopus 로고
    • One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation
    • Jardosh H.H., Sangani C.B., Patel M.P., Patel R.G., (2013) One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation. Chinese Chem Lett; 24: 123-126.
    • (2013) Chinese Chem Lett , vol.24 , pp. 123-126
    • Jardosh, H.H.1    Sangani, C.B.2    Patel, M.P.3    Patel, R.G.4
  • 59
    • 84868697714 scopus 로고    scopus 로고
    • Synthesis, characterization and antimicrobial activity of 1,3,4-oxadiazole bearing 1H-benzimidazole derivatives
    • In Press
    • Salahuddin,., Shaharyar M., Mazumder A., Abdullah M.M., (2012) Synthesis, characterization and antimicrobial activity of 1,3,4-oxadiazole bearing 1H-benzimidazole derivatives. Arabian J Chem. In Press, doi: 10.1016/j.arabjc.2012.10.010
    • (2012) Arabian J Chem
    • Salahuddin1    Shaharyar, M.2    Mazumder, A.3    Abdullah, M.M.4
  • 60
    • 84864005566 scopus 로고    scopus 로고
    • Synthesis and potent in vitro activity of novel 1H-benzimidazoles as anti-MRSA agents
    • Karatas H., Alp M., Ybox drawings light down and leftldbox drawings light down and leftz S., Goker H., (2012) Synthesis and potent in vitro activity of novel 1H-benzimidazoles as anti-MRSA agents. Chem Biol Drug Des; 80: 237-244.
    • (2012) Chem Biol Drug des , vol.80 , pp. 237-244
    • Karatas, H.1    Alp, M.2    Yildiz, S.3    Goker, H.4
  • 61
    • 77950345093 scopus 로고    scopus 로고
    • Inflammation 2010: New adventures of an old flame
    • Medzhitov R., (2010) Inflammation 2010: new adventures of an old flame. Cell; 140: 771-776.
    • (2010) Cell , vol.140 , pp. 771-776
    • Medzhitov, R.1
  • 62
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov S., Greten F.R., Karin M., (2010) Immunity, inflammation, and cancer. Cell; 140: 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.1    Greten, F.R.2    Karin, M.3
  • 63
    • 40049087863 scopus 로고    scopus 로고
    • Current status of COX-2 inhibitors
    • Singh P., Mittal A., (2008) Current status of COX-2 inhibitors. Mini Rev Med Chem; 8: 73-90.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 73-90
    • Singh, P.1    Mittal, A.2
  • 64
    • 77949490147 scopus 로고    scopus 로고
    • In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives
    • Achar K.C.S., Hosamani K.M., Seetharamareddy H.R., (2010) In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. Eur J Med Chem; 45: 2048-2054.
    • (2010) Eur J Med Chem , vol.45 , pp. 2048-2054
    • Achar, K.C.S.1    Hosamani, K.M.2    Seetharamareddy, H.R.3
  • 65
    • 77950864109 scopus 로고    scopus 로고
    • Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents
    • Gaba M., Singh D., Singh S., Sharma V., Gaba P., (2010) Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents. Eur J Med Chem; 45: 2245-2249.
    • (2010) Eur J Med Chem , vol.45 , pp. 2245-2249
    • Gaba, M.1    Singh, D.2    Singh, S.3    Sharma, V.4    Gaba, P.5
  • 66
    • 84988966315 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory activity of some phenylpyrazolobenzimidazoloquinoxaline derivatives
    • Sridevi C., Balaji K., Naidu A., Sudhakaran R., (2009) Antioxidant and anti-inflammatory activity of some phenylpyrazolobenzimidazoloquinoxaline derivatives. J Pharma Res; 2: 1500-1503.
    • (2009) J Pharma Res , vol.2 , pp. 1500-1503
    • Sridevi, C.1    Balaji, K.2    Naidu, A.3    Sudhakaran, R.4
  • 67
  • 68
    • 78249245507 scopus 로고    scopus 로고
    • Synthesis and biological activity of 2-(thiazolidin-4-one) phenyl]-1H-phenylbenzimidazoles and 2-[4-(azetidin-2-One)-3-chloro-4-phenyl]-1H-phenyl benzimidazoles
    • Shanmugapandiyan P., Denshing K.S., Ilavarasan R., Anbalagan N., Nirmal R., (2010) Synthesis and biological activity of 2-(thiazolidin-4-one) phenyl]-1H-phenylbenzimidazoles and 2-[4-(azetidin-2-One)-3-chloro-4-phenyl]-1H-phenyl benzimidazoles. Inte J Pharm Sci Drug Res; 2: 115-119.
    • (2010) Inte J Pharm Sci Drug Res , vol.2 , pp. 115-119
    • Shanmugapandiyan, P.1    Denshing, K.S.2    Ilavarasan, R.3    Anbalagan, N.4    Nirmal, R.5
  • 69
    • 84875210886 scopus 로고    scopus 로고
    • Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity
    • El-Nezhawy A.O.H., Biuomy A.R., Hassan F.S., Ismaiel A.K., Omar H.A., (2013) Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity. Bioorg Med Chem; 21: 1661-1670.
    • (2013) Bioorg Med Chem , vol.21 , pp. 1661-1670
    • El-Nezhawy, A.O.H.1    Biuomy, A.R.2    Hassan, F.S.3    Ismaiel, A.K.4    Omar, H.A.5
  • 70
    • 85028253989 scopus 로고    scopus 로고
    • Synthesis and in-silico molecular docking simulation of 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones as novel analgesic anti-inflammatory agent
    • In Press
    • Chhajed S.S., Upasani C.D., (2012) Synthesis and in-silico molecular docking simulation of 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones as novel analgesic anti-inflammatory agent. Arabian J Chem. In Press, doi: 10.1016/j.arabjc.2012.04.038
    • (2012) Arabian J Chem
    • Chhajed, S.S.1    Upasani, C.D.2
  • 72
    • 77958005386 scopus 로고    scopus 로고
    • Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure-activity relationships
    • Hayashi S., Nakata E., Morita A., Mizuno K., Yamamura K., Kato A., Ohashi K., (2010) Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Bioorg Med Chem; 18: 7675-7699.
    • (2010) Bioorg Med Chem , vol.18 , pp. 7675-7699
    • Hayashi, S.1    Nakata, E.2    Morita, A.3    Mizuno, K.4    Yamamura, K.5    Kato, A.6    Ohashi, K.7
  • 73
    • 44649102705 scopus 로고    scopus 로고
    • Synthesis and analgesic/anti a inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety
    • Shaaban M.R., Saleh T.S., Mayhoub A.S., Mansour A., Farag A.M., (2008) Synthesis and analgesic/anti a inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety. Bioorg Med Chem; 16: 6344-6352.
    • (2008) Bioorg Med Chem , vol.16 , pp. 6344-6352
    • Shaaban, M.R.1    Saleh, T.S.2    Mayhoub, A.S.3    Mansour, A.4    Farag, A.M.5
  • 75
    • 84861187425 scopus 로고    scopus 로고
    • Synthesis, characterization and evaluation of novel N-(1H-benzimidazol-2-yl)-2-isatinylidene-hydrazinecarboxamide derivatives as anti-inflammatory agents
    • Babu G.S., Rajani N., Malathy P.S., Srinivas B., Kulandaivelu U., Rao J.V., (2010) Synthesis, characterization and evaluation of novel N-(1H-benzimidazol-2-yl)-2-isatinylidene-hydrazinecarboxamide derivatives as anti-inflammatory agents. Der Pharma Chemica; 2: 196-204.
    • (2010) Der Pharma Chemica , vol.2 , pp. 196-204
    • Babu, G.S.1    Rajani, N.2    Malathy, P.S.3    Srinivas, B.4    Kulandaivelu, U.5    Rao, J.V.6
  • 83
    • 0003082670 scopus 로고
    • Tuberculosis: Pathogenesis, protection, and control
    • Bloom B. editor. Washington, DC: ASM Press
    • Smith P., Moss A., (1994) Tuberculosis: pathogenesis, protection, and control. In:, Bloom B., editor. Epidemiology of Tuberculosis. Washington, DC: ASM Press; p. 47.
    • (1994) Epidemiology of Tuberculosis , pp. 47
    • Smith, P.1    Moss, A.2
  • 84
    • 67651163413 scopus 로고    scopus 로고
    • Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles
    • Shingalapur R.V., Hosamani K.M., Keri R.S., (2009) Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles. Eur J Med Chem; 44: 4244-4248.
    • (2009) Eur J Med Chem , vol.44 , pp. 4244-4248
    • Shingalapur, R.V.1    Hosamani, K.M.2    Keri, R.S.3
  • 86
    • 67349280375 scopus 로고    scopus 로고
    • SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazole sas antimicrobial and antituberculosis agents
    • Jadhav G.R., Shaikh M.U., Kale R.P., Shiradkar M.R., Gill C.H., (2009) SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazole sas antimicrobial and antituberculosis agents. Eur J Med Chem; 44: 2930-2935.
    • (2009) Eur J Med Chem , vol.44 , pp. 2930-2935
    • Jadhav, G.R.1    Shaikh, M.U.2    Kale, R.P.3    Shiradkar, M.R.4    Gill, C.H.5
  • 88
    • 13444259612 scopus 로고    scopus 로고
    • Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles
    • Kazimierczuk Z., Andrzejewska M., Kaustova J., Klimesova V., (2005) Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles. Eur J Med Chem; 40: 203-208.
    • (2005) Eur J Med Chem , vol.40 , pp. 203-208
    • Kazimierczuk, Z.1    Andrzejewska, M.2    Kaustova, J.3    Klimesova, V.4
  • 89
    • 0036534079 scopus 로고    scopus 로고
    • New benzimidazole derivatives as antimycobacterial agents
    • Klimesova V., Koc J., Waisser K., Kaustova J., (2002) New benzimidazole derivatives as antimycobacterial agents. Farmaco; 57: 259-265.
    • (2002) Farmaco , vol.57 , pp. 259-265
    • Klimesova, V.1    Koc, J.2    Waisser, K.3    Kaustova, J.4
  • 90
    • 84861641797 scopus 로고    scopus 로고
    • Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl)acetamides as antibacterial, antifungal and antituberculosis agents
    • Patel R.V., Patel P.K., Kumari P., Rajani D.P., Chikhalia K.H., (2012) Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl)acetamides as antibacterial, antifungal and antituberculosis agents. Eur J Med Chem; 53: 41-51.
    • (2012) Eur J Med Chem , vol.53 , pp. 41-51
    • Patel, R.V.1    Patel, P.K.2    Kumari, P.3    Rajani, D.P.4    Chikhalia, K.H.5
  • 92
    • 84924375326 scopus 로고    scopus 로고
    • Synthesis and evaluation of antimycobacterial activity of new benzimidazoleaminoesters
    • In Press, doi: 10.1016/j.ejmech.2013.06.025
    • Yoon Y.K., Ali M.A., Wei A.C., Choon T.S., Ismail R., (2013) Synthesis and evaluation of antimycobacterial activity of new benzimidazoleaminoesters. Eur J Med Chem. In Press, doi: 10.1016/j.ejmech.2013.06.025
    • (2013) Eur J Med Chem
    • Yoon, Y.K.1    Ali, M.A.2    Wei, A.C.3    Choon, T.S.4    Ismail, R.5
  • 93
    • 79251569911 scopus 로고    scopus 로고
    • Pyrido[1,2-a]benzimidazole-based agents active against tuberculosis (TB), multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB
    • Pieroni M., Tipparaju S.K., Lun S., Song Y., Sturm A.W., Bishai W.R., Kozikowski A.P., (2011) Pyrido[1,2-a]benzimidazole-based agents active against tuberculosis (TB), multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB. Chem Med Chem; 6: 334-342.
    • (2011) Chem Med Chem , vol.6 , pp. 334-342
    • Pieroni, M.1    Tipparaju, S.K.2    Lun, S.3    Song, Y.4    Sturm, A.W.5    Bishai, W.R.6    Kozikowski, A.P.7
  • 94
    • 79952453594 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents
    • Camacho J., Barazarte A., Gamboa N., Rodrigues J., Rojas R., Vaisberg A., Gilman R., Charris J., (2011) Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents. Bioorg Med Chem; 19: 2023-2029.
    • (2011) Bioorg Med Chem , vol.19 , pp. 2023-2029
    • Camacho, J.1    Barazarte, A.2    Gamboa, N.3    Rodrigues, J.4    Rojas, R.5    Vaisberg, A.6    Gilman, R.7    Charris, J.8
  • 95
    • 0037378445 scopus 로고    scopus 로고
    • The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The Renaal study
    • Keane W.F., Brenner B.M., (2003) The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the Renaal study. Kidney Int; 63: 1499-1507.
    • (2003) Kidney Int , vol.63 , pp. 1499-1507
    • Keane, W.F.1    Brenner, B.M.2
  • 96
    • 20544475805 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: Putative neurobiologic and clinical mechanisms
    • Schmidt D., Loscher W., (2005) Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia; 46: 858-877.
    • (2005) Epilepsia , vol.46 , pp. 858-877
    • Schmidt, D.1    Loscher, W.2
  • 98
    • 77949486916 scopus 로고    scopus 로고
    • Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies
    • Shingalapur R.V., Hosamani K.M., Keri R.S., Hugar M.H., (2010) Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies. Eur J Med Chem; 45: 1753-1759.
    • (2010) Eur J Med Chem , vol.45 , pp. 1753-1759
    • Shingalapur, R.V.1    Hosamani, K.M.2    Keri, R.S.3    Hugar, M.H.4
  • 99
    • 79961227933 scopus 로고    scopus 로고
    • Synthesis, anti-tumor, anti-diabetic, and anti- asthmatic activitives of some novel benzimidazole derivatives
    • Vijayakumar K., Ahamed A.J., (2010) Synthesis, anti-tumor, anti-diabetic, and anti- asthmatic activitives of some novel benzimidazole derivatives. J Chem Pharm Res; 2: 215-224.
    • (2010) J Chem Pharm Res , vol.2 , pp. 215-224
    • Vijayakumar, K.1    Ahamed, A.J.2
  • 100
    • 77955360270 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity
    • Jain P., Sharma P.K., Rajak H., Pawar R.S., Patil U.K., Singour P., (2010) Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity. Arch Pharm Res; 33: 971-980.
    • (2010) Arch Pharm Res , vol.33 , pp. 971-980
    • Jain, P.1    Sharma, P.K.2    Rajak, H.3    Pawar, R.S.4    Patil, U.K.5    Singour, P.6
  • 101
    • 43249115967 scopus 로고    scopus 로고
    • Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H benzimidazoles
    • Vinodkumar R., Vaidya S.D., Kumar B.V.S., Bhise U.N., Bhirud S.B., Mashelkar U.C., (2008) Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H benzimidazoles. Eur J Med Chem; 43: 986-995.
    • (2008) Eur J Med Chem , vol.43 , pp. 986-995
    • Vinodkumar, R.1    Vaidya, S.D.2    Kumar, B.V.S.3    Bhise, U.N.4    Bhirud, S.B.5    Mashelkar, U.C.6
  • 102
    • 84880578938 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents
    • Kwak H.J., Pyun Y.M., Kim J.Y., Pagire H.S., Kim K.Y., Kim K.R., Rhee S.D., Jung W.H., (2013) Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents. Bioorg Med Chem Lett; 23: 4713-4718.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 4713-4718
    • Kwak, H.J.1    Pyun, Y.M.2    Kim, J.Y.3    Pagire, H.S.4    Kim, K.Y.5    Kim, K.R.6    Rhee, S.D.7    Jung, W.H.8
  • 104
    • 3242752786 scopus 로고    scopus 로고
    • Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
    • Boonstra J., Post J.A., (2004) Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene; 337: 1-13.
    • (2004) Gene , vol.337 , pp. 1-13
    • Boonstra, J.1    Post, J.A.2
  • 106
    • 80051665640 scopus 로고    scopus 로고
    • Neuroprotective strategies involving ROS in Alzheimer disease
    • Dumont M., Beal M.F., (2011) Neuroprotective strategies involving ROS in Alzheimer disease. Free Radical Biol Med; 51: 1014-1026.
    • (2011) Free Radical Biol Med , vol.51 , pp. 1014-1026
    • Dumont, M.1    Beal, M.F.2
  • 108
    • 84866042834 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress in the maintenance of myocardial function
    • Zhang Y., Tocchetti C.G., Krieg T., Moens A.L., (2012) Oxidative and nitrosative stress in the maintenance of myocardial function. Free Radical Biol Med; 53: 1531-1540.
    • (2012) Free Radical Biol Med , vol.53 , pp. 1531-1540
    • Zhang, Y.1    Tocchetti, C.G.2    Krieg, T.3    Moens, A.L.4
  • 110
    • 36549058379 scopus 로고    scopus 로고
    • Synthesis and antioxidant capacities of some new benzimidazole derivatives
    • Ayhan-Kbox drawings light down and leftlcbox drawings light down and leftgil G., Kus C., Ozdamar E.D., Can-Eke B., Iscan M., (2007) Synthesis and antioxidant capacities of some new benzimidazole derivatives. Arch Pharm Chem Life Sci; 340: 607-611.
    • (2007) Arch Pharm Chem Life Sci , vol.340 , pp. 607-611
    • Ayhan-Kilcigil, G.1    Kus, C.2    Ozdamar, E.D.3    Can-Eke, B.4    Iscan, M.5
  • 111
    • 36749033771 scopus 로고    scopus 로고
    • Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives
    • Kerimov I., Ayhan-Kilcigil G., Can-Eke B., Altanlar N., Iscan M., (2007) Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives. J Enz Inhib Med Chem; 22: 696-701.
    • (2007) J Enz Inhib Med Chem , vol.22 , pp. 696-701
    • Kerimov, I.1    Ayhan-Kilcigil, G.2    Can-Eke, B.3    Altanlar, N.4    Iscan, M.5
  • 112
    • 84880135421 scopus 로고    scopus 로고
    • Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-triazol ring
    • Mentes E., Karaali N., Ybox drawings light down and leftlmaz F., Ülker S., Kahveci B., (2013) Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-triazol ring. Arch Pharm Chem Life Sci; 346: 556-561.
    • (2013) Arch Pharm Chem Life Sci , vol.346 , pp. 556-561
    • Mentes, E.1    Karaali, N.2    Yilmaz, F.3    Ülker, S.4    Kahveci, B.5
  • 113
    • 84863706850 scopus 로고    scopus 로고
    • Design and one-pot and microwave-assisted synthesis of 2-amino/5-aryl-1,3,4-oxadiazoles bearing a benzimidazole moiety as antioxidants
    • Kerimov I., Ayhan-Kbox drawings light down and leftlcbox drawings light down and leftgil G., Ozdama E.D., Can-Eke B., Coban T., Ozbey S., Kazak C., (2012) Design and one-pot and microwave-assisted synthesis of 2-amino/5-aryl-1,3,4-oxadiazoles bearing a benzimidazole moiety as antioxidants. Arch Pharm Chem Life Sci; 345: 549-556.
    • (2012) Arch Pharm Chem Life Sci , vol.345 , pp. 549-556
    • Kerimov, I.1    Ayhan-Klcgil, G.2    Ozdama, E.D.3    Can-Eke, B.4    Coban, T.5    Ozbey, S.6    Kazak, C.7
  • 114
    • 0035138734 scopus 로고    scopus 로고
    • Drug targets and mechanisms of resistance in the anaerobic protozoa
    • Upcroft P., Upcroft J.A., (2001) Drug targets and mechanisms of resistance in the anaerobic protozoa. Clin Microbiol Rev; 14: 150-164.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 150-164
    • Upcroft, P.1    Upcroft, J.A.2
  • 117
    • 34447640547 scopus 로고    scopus 로고
    • Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines
    • Mavrova A.T., Denkova P., Tsenov Y.A., Anichina K.K., Vutchev D.I., (2007) Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines. Bioorg Med Chem; 15: 6291-6297.
    • (2007) Bioorg Med Chem , vol.15 , pp. 6291-6297
    • Mavrova, A.T.1    Denkova, P.2    Tsenov, Y.A.3    Anichina, K.K.4    Vutchev, D.I.5
  • 119
    • 79958252481 scopus 로고    scopus 로고
    • Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of some benzimidazole derivatives with trichomonicidal activity
    • Pérez-Villanueva J., Medina-Franco J.L., Caulfield T.R., Hernández-Campos A., Hernández-Luis F., Yépez-Mulia L., Castillo R., (2011) Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of some benzimidazole derivatives with trichomonicidal activity. Eur J Med Chem; 46: 3499-3508.
    • (2011) Eur J Med Chem , vol.46 , pp. 3499-3508
    • Pérez-Villanueva, J.1    Medina-Franco, J.L.2    Caulfield, T.R.3    Hernández-Campos, A.4    Hernández-Luis, F.5    Yépez-Mulia, L.6    Castillo, R.7
  • 123
    • 34248159068 scopus 로고    scopus 로고
    • Small molecule vascular disrupting agents: Potential new drugs for cancer treatment
    • Cai S.X., (2007) Small molecule vascular disrupting agents: potential new drugs for cancer treatment. Recent Pat Anti-Cancer Drug Discov; 2: 79-101.
    • (2007) Recent Pat Anti-Cancer Drug Discov , vol.2 , pp. 79-101
    • Cai, S.X.1
  • 126
    • 78650515063 scopus 로고    scopus 로고
    • Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities
    • Demirayak S., Kayagil I., Yurttas L., (2011) Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities. Eur J Med Chem; 46: 411-416.
    • (2011) Eur J Med Chem , vol.46 , pp. 411-416
    • Demirayak, S.1    Kayagil, I.2    Yurttas, L.3
  • 127
    • 77954349595 scopus 로고    scopus 로고
    • Synthesis and anticancer activity of some novel 2-substituted benzimidazole derivatives
    • Refaat H.M., (2010) Synthesis and anticancer activity of some novel 2-substituted benzimidazole derivatives. Eur J Med Chem; 45: 2949-2956.
    • (2010) Eur J Med Chem , vol.45 , pp. 2949-2956
    • Refaat, H.M.1
  • 128
  • 129
    • 77955557677 scopus 로고    scopus 로고
    • Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents
    • Moriarty E., Carr M., Bonham S., Carty M.P., Aldabbagh F., (2010) Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents. Eur J Med Chem; 45: 3762-3769.
    • (2010) Eur J Med Chem , vol.45 , pp. 3762-3769
    • Moriarty, E.1    Carr, M.2    Bonham, S.3    Carty, M.P.4    Aldabbagh, F.5
  • 130
    • 77949484802 scopus 로고    scopus 로고
    • The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells
    • Fahey K., O'Donovan L., Carr M., Carty M.P., Aldabbagh F., (2010) The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells. Eur J Med Chem; 45: 1873-1879.
    • (2010) Eur J Med Chem , vol.45 , pp. 1873-1879
    • Fahey, K.1    O'Donovan, L.2    Carr, M.3    Carty, M.P.4    Aldabbagh, F.5
  • 131
    • 55849149810 scopus 로고    scopus 로고
    • First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells
    • O'Donovan L., Carty M.P., Aldabbagh F., (2008) First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells. Chem Comm; 43: 5592-5594.
    • (2008) Chem Comm , vol.43 , pp. 5592-5594
    • O'Donovan, L.1    Carty, M.P.2    Aldabbagh, F.3
  • 132
    • 80052765449 scopus 로고    scopus 로고
    • First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines
    • Bonham S., O'Donovan L., Carty M.P., Aldabbagh F., (2011) First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines. Org Biomol Chem; 9: 6700-6706.
    • (2011) Org Biomol Chem , vol.9 , pp. 6700-6706
    • Bonham, S.1    O'Donovan, L.2    Carty, M.P.3    Aldabbagh, F.4
  • 133
    • 79955571972 scopus 로고    scopus 로고
    • Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles
    • Hranjec M., Starcevic K., Pavelic S.K., Lucin P., Pavelic K., Zamola G.K., (2011) Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles. Eur J Med Chem; 46: 2274-2279.
    • (2011) Eur J Med Chem , vol.46 , pp. 2274-2279
    • Hranjec, M.1    Starcevic, K.2    Pavelic, S.K.3    Lucin, P.4    Pavelic, K.5    Zamola, G.K.6
  • 134
    • 84864213321 scopus 로고    scopus 로고
    • The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic Lymphoma Kinase (ALK) inhibitors with potential utility for the treatment of cancer
    • Lewis R.T., Bode C.M., Choquette D.M., Potashman M., Romero K., Stellwagen J.C., Teffera Y., et al,. (2012) The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic Lymphoma Kinase (ALK) inhibitors with potential utility for the treatment of cancer. J Med Chem; 55: 6523-6540.
    • (2012) J Med Chem , vol.55 , pp. 6523-6540
    • Lewis, R.T.1    Bode, C.M.2    Choquette, D.M.3    Potashman, M.4    Romero, K.5    Stellwagen, J.C.6    Teffera, Y.7
  • 135
    • 80052956378 scopus 로고    scopus 로고
    • Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents
    • Abonia R., Cortés E., Insuasty B., Quiroga J., Nogueras M., Cobo J., (2011) Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents. Eur J Med Chem; 46: 4062-4070.
    • (2011) Eur J Med Chem , vol.46 , pp. 4062-4070
    • Abonia, R.1    Cortés, E.2    Insuasty, B.3    Quiroga, J.4    Nogueras, M.5    Cobo, J.6
  • 136
    • 78650517443 scopus 로고    scopus 로고
    • Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives
    • Luo Y., Xiao F., Qian S., Lu W., Yang B., (2011) Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives. Eur J Med Chem; 46: 417-422.
    • (2011) Eur J Med Chem , vol.46 , pp. 417-422
    • Luo, Y.1    Xiao, F.2    Qian, S.3    Lu, W.4    Yang, B.5
  • 137
    • 79958278737 scopus 로고    scopus 로고
    • Synthesis, characterization and cytotoxicity of some novel 1,3-disubstituted-2,3-dihydro-2-iminobenzimidazoles
    • Mavrova A.T., Wesselinova D., Vassilev N., Tsenov J.A., (2011) Synthesis, characterization and cytotoxicity of some novel 1,3-disubstituted-2,3-dihydro-2-iminobenzimidazoles. Eur J Med Chem; 46: 3362-3367.
    • (2011) Eur J Med Chem , vol.46 , pp. 3362-3367
    • Mavrova, A.T.1    Wesselinova, D.2    Vassilev, N.3    Tsenov, J.A.4
  • 138
    • 84865114436 scopus 로고    scopus 로고
    • Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents
    • Husain A., Rashid M., Mishra R., Parveen S., Shin D., Kumar D., (2012) Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: design and synthesis as anticancer agents. Bioorg Med Chem Lett; 22: 5438-5444.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 5438-5444
    • Husain, A.1    Rashid, M.2    Mishra, R.3    Parveen, S.4    Shin, D.5    Kumar, D.6
  • 139
    • 84864408927 scopus 로고    scopus 로고
    • Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents
    • Rashid M., Husain A., Mishra R., (2012) Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents. Eur J Med Chem; 54: 855-866.
    • (2012) Eur J Med Chem , vol.54 , pp. 855-866
    • Rashid, M.1    Husain, A.2    Mishra, R.3
  • 140
    • 84856226664 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of benzo[d]imidazole derivative sas potential anti-cancer agents
    • Alkahtani H.M., Abbas A.Y., Wang S., (2012) Synthesis and biological evaluation of benzo[d]imidazole derivative sas potential anti-cancer agents. Bioorg Med Chem Lett; 22: 1317-1321.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 1317-1321
    • Alkahtani, H.M.1    Abbas, A.Y.2    Wang, S.3
  • 142
    • 84861585900 scopus 로고    scopus 로고
    • Synthesis, antitumor activity and SAR study of novel [1, 2, 4]triazino[4,5-a]benzimidazole derivatives
    • El-Nassan H.B., (2012) Synthesis, antitumor activity and SAR study of novel [1, 2, 4]triazino[4,5-a]benzimidazole derivatives. Eur J Med Chem; 53: 22-27.
    • (2012) Eur J Med Chem , vol.53 , pp. 22-27
    • El-Nassan, H.B.1
  • 143
    • 84866380218 scopus 로고    scopus 로고
    • Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy
    • Wang X., Chu N., Wang Q., Liu C., Jiang C., Wang X., Ikejima T., Cheng M., (2012) Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy. Bioorg Med Chem Lett; 22: 6297-6300.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 6297-6300
    • Wang, X.1    Chu, N.2    Wang, Q.3    Liu, C.4    Jiang, C.5    Wang, X.6    Ikejima, T.7    Cheng, M.8
  • 144
    • 84859833654 scopus 로고    scopus 로고
    • Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide derivatives as antitumor agents
    • Liu T., Sun C., Xing X., Jing L., Tan R., Luo Y., Huang W., Song H., Li Z., Zhao Y., (2012) Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide derivatives as antitumor agents. Bioorg Med Chem Lett; 22: 3122-3125.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 3122-3125
    • Liu, T.1    Sun, C.2    Xing, X.3    Jing, L.4    Tan, R.5    Luo, Y.6    Huang, W.7    Song, H.8    Li, Z.9    Zhao, Y.10
  • 146
    • 84878112035 scopus 로고    scopus 로고
    • Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity
    • Paul K., Bindal S., Luxami V., (2013) Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity. Bioorg Med Chem Lett; 2: 3667-3672.
    • (2013) Bioorg Med Chem Lett , vol.2 , pp. 3667-3672
    • Paul, K.1    Bindal, S.2    Luxami, V.3
  • 147
    • 84876013863 scopus 로고    scopus 로고
    • Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents
    • Husain A., Rashid M., Shaharyar M., Siddiqui A.A., Mishra R., (2013) Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: new anticancer agents. Eur J Med Chem; 62: 785-798.
    • (2013) Eur J Med Chem , vol.62 , pp. 785-798
    • Husain, A.1    Rashid, M.2    Shaharyar, M.3    Siddiqui, A.A.4    Mishra, R.5
  • 148
    • 84872687427 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
    • Wang X., Liu L., Li Y., Sun C., Chen W., Li L., Zhang H., Yang X., (2013) Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents. Eur J Med Chem; 62: 111-121.
    • (2013) Eur J Med Chem , vol.62 , pp. 111-121
    • Wang, X.1    Liu, L.2    Li, Y.3    Sun, C.4    Chen, W.5    Li, L.6    Zhang, H.7    Yang, X.8
  • 149
    • 84875966270 scopus 로고    scopus 로고
    • Design, synthesis and antiproliferative properties of some new 5-substituted-2-iminobenzimidazole derivatives
    • Mavrov A.T., Wesselinov D., Vassilev N., Tsenov J.A., (2013) Design, synthesis and antiproliferative properties of some new 5-substituted-2-iminobenzimidazole derivatives. Eur J Med Chem; 63: 696-701.
    • (2013) Eur J Med Chem , vol.63 , pp. 696-701
    • Mavrov, A.T.1    Wesselinov, D.2    Vassilev, N.3    Tsenov, J.A.4
  • 151
    • 84879809375 scopus 로고    scopus 로고
    • Synthesis and antitumor activities of novel dibenzo [b,d]furan-imidazole hybrid compounds
    • Liu L., Wang X., Yan J., Li Y., Sun C., Chen W., Zhou B., Zhang H., Yang X., (2013) Synthesis and antitumor activities of novel dibenzo [b,d]furan-imidazole hybrid compounds. Eur J Med Chem; 66: 423-437.
    • (2013) Eur J Med Chem , vol.66 , pp. 423-437
    • Liu, L.1    Wang, X.2    Yan, J.3    Li, Y.4    Sun, C.5    Chen, W.6    Zhou, B.7    Zhang, H.8    Yang, X.9
  • 152
    • 84877584458 scopus 로고    scopus 로고
    • Synthesis, single crystal and antitumor activities of benzimidazole-quinazoline hybrids
    • Sharma A., Luxami V., Paul K., (2013) Synthesis, single crystal and antitumor activities of benzimidazole-quinazoline hybrids. Bioorg Med Chem Lett; 23: 3288-3294.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 3288-3294
    • Sharma, A.1    Luxami, V.2    Paul, K.3
  • 153
    • 84884270204 scopus 로고    scopus 로고
    • Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; Synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones
    • Puttaraju K.B., Shivashankar K., Chandra M.M., Mahendra M., Rasal V.P., Vivek P.N.V., Rai K., Chanu M.B., (2013) Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones. Eur J Med Chem; 69: 316-322.
    • (2013) Eur J Med Chem , vol.69 , pp. 316-322
    • Puttaraju, K.B.1    Shivashankar, K.2    Chandra, M.M.3    Mahendra, M.4    Rasal, V.P.5    Vivek, P.N.V.6    Rai, K.7    Chanu, M.B.8
  • 154
    • 84879684460 scopus 로고    scopus 로고
    • Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds
    • Chen W., Deng X., Li Y., Yang L., Wana W., Wanga X., Zhang H., Yang X., (2013) Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds. Bioorg Med Chem Lett; 23: 4297-4302.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 4297-4302
    • Chen, W.1    Deng, X.2    Li, Y.3    Yang, L.4    Wana, W.5    Wanga, X.6    Zhang, H.7    Yang, X.8
  • 155
    • 84861857801 scopus 로고    scopus 로고
    • Synthesis of potential anticancer derivatives of pyrido[1,2-a]benzimidazoles
    • Refaat H.M., (2012) Synthesis of potential anticancer derivatives of pyrido[1,2-a]benzimidazoles. Med Chem Res; 21: 1253-1260.
    • (2012) Med Chem Res , vol.21 , pp. 1253-1260
    • Refaat, H.M.1
  • 156
    • 84873997765 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of new 4-thiazolidinone derivatives substituted with benzimidazole ring as potential chemotherapeutic agents
    • Masoud G.N., Youssef A.M., Khalek M.M.A., Wahab A.E.A., Labouta I.M., Hazzaa A.A.B., (2013) Design, synthesis, and biological evaluation of new 4-thiazolidinone derivatives substituted with benzimidazole ring as potential chemotherapeutic agents. Med Chem Res; 22: 707-725.
    • (2013) Med Chem Res , vol.22 , pp. 707-725
    • Masoud, G.N.1    Youssef, A.M.2    Khalek, M.M.A.3    Wahab, A.E.A.4    Labouta, I.M.5    Hazzaa, A.A.B.6
  • 157
    • 84877730342 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of some 1,2- disubstituted benzimidazole derivatives as new potential anticancer agents
    • Yurttas L., Demirayak S., Ciftci G.A., Ybox drawings light down and leftldbox drawings light down and leftrbox drawings light down and leftm S.U., Kaplancbox drawings light down and leftk Z.A., (2013) Synthesis and biological evaluation of some 1,2- disubstituted benzimidazole derivatives as new potential anticancer agents. Arch Pharm Chem Life Sci; 346: 403-414.
    • (2013) Arch Pharm Chem Life Sci , vol.346 , pp. 403-414
    • Yurttas, L.1    Demirayak, S.2    Ciftci, G.A.3    Yldrm, S.U.4    Kaplanck, Z.A.5
  • 158
    • 80052946477 scopus 로고    scopus 로고
    • Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents
    • Elzahabi H.S.A., (2011) Synthesis, characterization of some benzazoles bearing pyridine moiety: search for novel anticancer agents. Eur J Med Chem; 46: 4025-4034.
    • (2011) Eur J Med Chem , vol.46 , pp. 4025-4034
    • Elzahabi, H.S.A.1
  • 159
    • 60549084927 scopus 로고    scopus 로고
    • Design, structure activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A novel class of receptor tyrosine kinase inhibitors
    • Renhowe P.A., Pecchi S., Shafer C.M., Machajewski T.D., Jazan E.M., Taylor C., Antonios-McCrea W., et al,. (2009) Design, structure activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor tyrosine kinase inhibitors. J Med Chem; 52: 278-292.
    • (2009) J Med Chem , vol.52 , pp. 278-292
    • Renhowe, P.A.1    Pecchi, S.2    Shafer, C.M.3    MacHajewski, T.D.4    Jazan, E.M.5    Taylor, C.6    Antonios-Mccrea, W.7
  • 160
    • 53549109444 scopus 로고    scopus 로고
    • Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity
    • Velaparthi U., Wittman M., Liu P., Carboni J.M., Lee F.Y., Attar R., Balimane P., et al,. (2008) Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity. J Med Chem; 51: 5897-5900.
    • (2008) J Med Chem , vol.51 , pp. 5897-5900
    • Velaparthi, U.1    Wittman, M.2    Liu, P.3    Carboni, J.M.4    Lee, F.Y.5    Attar, R.6    Balimane, P.7
  • 162
    • 77950864000 scopus 로고    scopus 로고
    • Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a] quinolines and fluorenes: Synthesis, antitumor evaluation in vitro and crystal structure determination
    • Hranjec M., Pavlovic G., Marjanovic M., Kralj M., Karminski-Zamola G., (2010) Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a] quinolines and fluorenes: synthesis, antitumor evaluation in vitro and crystal structure determination. Eur J Med Chem; 45: 2405-2417.
    • (2010) Eur J Med Chem , vol.45 , pp. 2405-2417
    • Hranjec, M.1    Pavlovic, G.2    Marjanovic, M.3    Kralj, M.4    Karminski-Zamola, G.5
  • 163
    • 77950861035 scopus 로고    scopus 로고
    • Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues
    • Sarhan A.A.O., Al-Dhfyan A., Al-Mozaini M.A., Adra C.N., Aboul-Fadl T., (2010) Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues. Eur J Med Chem; 45: 2689-2694.
    • (2010) Eur J Med Chem , vol.45 , pp. 2689-2694
    • Sarhan, A.A.O.1    Al-Dhfyan, A.2    Al-Mozaini, M.A.3    Adra, C.N.4    Aboul-Fadl, T.5
  • 164
    • 71049158764 scopus 로고    scopus 로고
    • Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents
    • Tong Y., Bouska J.J., Ellis P.A., Johnson E.F., Leverson J., Liu X., Marcotte P.A., et al,. (2009) Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents. J Med Chem; 52: 6803-6813.
    • (2009) J Med Chem , vol.52 , pp. 6803-6813
    • Tong, Y.1    Bouska, J.J.2    Ellis, P.A.3    Johnson, E.F.4    Leverson, J.5    Liu, X.6    Marcotte, P.A.7
  • 165
    • 77954342540 scopus 로고    scopus 로고
    • 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase
    • Chang W., Chang C., Chiang P., Ho Y., Liu J., Chang K., Guh J., (2010) 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase. British J Pharm; 160: 1677-1689.
    • (2010) British J Pharm , vol.160 , pp. 1677-1689
    • Chang, W.1    Chang, C.2    Chiang, P.3    Ho, Y.4    Liu, J.5    Chang, K.6    Guh, J.7
  • 166
    • 74949102003 scopus 로고    scopus 로고
    • Facile synthesis and in-vitro antitumor activity of some pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidines linked to a thiazolo[3,2-a]benzimidazole moiety
    • Abdel-Aziz H.A., Saleh T.S., El-Zahabi H.S.A., (2010) Facile synthesis and in-vitro antitumor activity of some pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidines linked to a thiazolo[3,2-a]benzimidazole moiety. Arch Pharm Chem Life Sci; 343: 24-30.
    • (2010) Arch Pharm Chem Life Sci , vol.343 , pp. 24-30
    • Abdel-Aziz, H.A.1    Saleh, T.S.2    El-Zahabi, H.S.A.3
  • 167
    • 60749098230 scopus 로고    scopus 로고
    • N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity
    • Wang H., Yu N., Song H., Chen D., Zou Y., Deng W., Lye P.L., et al,. (2009) N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity. Bioorg Med Chem Lett; 19: 1403-1408.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 1403-1408
    • Wang, H.1    Yu, N.2    Song, H.3    Chen, D.4    Zou, Y.5    Deng, W.6    Lye, P.L.7
  • 168
    • 84881368436 scopus 로고    scopus 로고
    • Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents
    • Wang T., Sepulveda M., Gonzales P., Gately S., (2013) Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents. Bioorg Med Chem Lett; 23: 4790-4793.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 4790-4793
    • Wang, T.1    Sepulveda, M.2    Gonzales, P.3    Gately, S.4
  • 170
    • 84878105567 scopus 로고    scopus 로고
    • Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors
    • Zheng Y., Zheng M., Ling X., Liu Y., Xue Y., An L., Gu N., Jin M., (2013) Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors. Bioorg Med Chem Lett; 23: 3523-3530.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 3523-3530
    • Zheng, Y.1    Zheng, M.2    Ling, X.3    Liu, Y.4    Xue, Y.5    An, L.6    Gu, N.7    Jin, M.8
  • 173
    • 84859819839 scopus 로고    scopus 로고
    • Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents
    • Bacharaju K., Jambula S.R., Sivan S., Tangeda S.J., Manga V., (2013) Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents. Bioorg Med Chem Lett; 23: 3274-3277.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 3274-3277
    • Bacharaju, K.1    Jambula, S.R.2    Sivan, S.3    Tangeda, S.J.4    Manga, V.5
  • 174
    • 33746512140 scopus 로고    scopus 로고
    • The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic
    • Montaner J.S., Hogg R., Wood E., Kerr T., Tyndall M., Levy A.R., Harrigan P.R., (2006) The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet; 368: 531-536.
    • (2006) Lancet , vol.368 , pp. 531-536
    • Montaner, J.S.1    Hogg, R.2    Wood, E.3    Kerr, T.4    Tyndall, M.5    Levy, A.R.6    Harrigan, P.R.7
  • 177
    • 61449084539 scopus 로고    scopus 로고
    • Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivatives
    • Xu Y., Zeng C., Jiao Z., Hu L., Zhong R., (2009) Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivatives. Molecules; 14: 868-883.
    • (2009) Molecules , vol.14 , pp. 868-883
    • Xu, Y.1    Zeng, C.2    Jiao, Z.3    Hu, L.4    Zhong, R.5
  • 179
    • 78650514584 scopus 로고    scopus 로고
    • Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication
    • Skerlj R., Bridger G., McEachern E., Harwig C., Smith C., Wilson T., Veale D., et al,. (2011) Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication. Bioorg Med Chem Lett; 21: 262-266.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 262-266
    • Skerlj, R.1    Bridger, G.2    McEachern, E.3    Harwig, C.4    Smith, C.5    Wilson, T.6    Veale, D.7
  • 180
    • 84879685141 scopus 로고    scopus 로고
    • Molecular docking guided structure based design of symmetrical N,N'-disubstituted urea/thiourea as HIV-1 gp120-CD4 binding inhibitors
    • Sivan S.K., Vangala R., Manga V., (2013) Molecular docking guided structure based design of symmetrical N,N'-disubstituted urea/thiourea as HIV-1 gp120-CD4 binding inhibitors. Bioorg Med Chem; 21: 4591-4599.
    • (2013) Bioorg Med Chem , vol.21 , pp. 4591-4599
    • Sivan, S.K.1    Vangala, R.2    Manga, V.3
  • 181
    • 84870249453 scopus 로고    scopus 로고
    • Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold
    • Tremblay M., Bonneau P., Bousquet Y., DeRoy P., Duan J., Duplessis M., Gagnon A., et al,. (2012) Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold. Bioorg Med Chem Lett; 22: 7512-7517.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 7512-7517
    • Tremblay, M.1    Bonneau, P.2    Bousquet, Y.3    Deroy, P.4    Duan, J.5    Duplessis, M.6    Gagnon, A.7
  • 184
    • 73449148997 scopus 로고    scopus 로고
    • Structure of HIV-1 nonnucleoside reverse transcriptase inhibitors derivatives of N-benzyl-benzimidazole with different substituents in position 4
    • Ziołkowska N.E., Michejda C.J., Bujacz G.D., (2010) Structure of HIV-1 nonnucleoside reverse transcriptase inhibitors derivatives of N-benzyl-benzimidazole with different substituents in position 4. J Mol Structure; 963: 188-193.
    • (2010) J Mol Structure , vol.963 , pp. 188-193
    • Ziołkowska, N.E.1    Michejda, C.J.2    Bujacz, G.D.3
  • 188
    • 0033934529 scopus 로고    scopus 로고
    • Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(β-d-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability
    • Gudmundsson K S., Freeman G.A., Drach J.C., Townsend L.B., (2000) Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(β-d-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability. J Med Chem; 43: 2473-2478.
    • (2000) J Med Chem , vol.43 , pp. 2473-2478
    • Gudmundsson, K.S.1    Freeman, G.A.2    Drach, J.C.3    Townsend, L.B.4
  • 189
    • 77951100819 scopus 로고    scopus 로고
    • Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication
    • Skerlj R.T., Bridger G.J., Kaller A., McEachern E.J., Crawford J.B., Zhou Y., Atsma B., et al,. (2000) Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem; 53: 3376-3388.
    • (2000) J Med Chem , vol.53 , pp. 3376-3388
    • Skerlj, R.T.1    Bridger, G.J.2    Kaller, A.3    McEachern, E.J.4    Crawford, J.B.5    Zhou, Y.6    Atsma, B.7
  • 191
    • 79958140590 scopus 로고    scopus 로고
    • Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go-related gene (hERG) profile
    • Kazmierski W.M., Anderson D.L., Aquino C., Chauder B.A., Duan M., Ferris R., Kenakin T., et al,. (2011) Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go-related gene (hERG) profile. J Med Chem; 54: 3756-3767.
    • (2011) J Med Chem , vol.54 , pp. 3756-3767
    • Kazmierski, W.M.1    Anderson, D.L.2    Aquino, C.3    Chauder, B.A.4    Duan, M.5    Ferris, R.6    Kenakin, T.7
  • 192
    • 78651075863 scopus 로고    scopus 로고
    • An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: The discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo [4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)
    • Stupple P.A., Batchelor D.V., Corless M., Dorr P.K., Ellis D., Fenwick D.R., Galan S.R.G., et al,. (2011) An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo [4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798). J Med Chem; 54: 67-77.
    • (2011) J Med Chem , vol.54 , pp. 67-77
    • Stupple, P.A.1    Batchelor, D.V.2    Corless, M.3    Dorr, P.K.4    Ellis, D.5    Fenwick, D.R.6    Galan, S.R.G.7
  • 194
    • 3042747893 scopus 로고    scopus 로고
    • Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives
    • Zhu X., Guan J., Xiao Z., Cosentino L M., Lee K., (2004) Anti-AIDS agents. Part 61: anti-HIV activity of new podophyllotoxin derivatives. Bioorg Med Chem; 12: 4267-4273.
    • (2004) Bioorg Med Chem , vol.12 , pp. 4267-4273
    • Zhu, X.1    Guan, J.2    Xiao, Z.3    Cosentino, L.M.4    Lee, K.5
  • 195
    • 78751621217 scopus 로고    scopus 로고
    • Evolving epidemiology of hepatitis C virus
    • Lavanchy D., (2011) Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect; 17: 107-115.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 107-115
    • Lavanchy, D.1
  • 197
    • 67349105629 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: A meta-analysis
    • Raimondi S., Bruno S., Mondelli M.U., Maisonneuve P., (2009) Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis. J Hepatol; 50: 1142-1154.
    • (2009) J Hepatol , vol.50 , pp. 1142-1154
    • Raimondi, S.1    Bruno, S.2    Mondelli, M.U.3    Maisonneuve, P.4
  • 199
    • 67649303095 scopus 로고    scopus 로고
    • Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection
    • Beaulieu P.L., (2009) Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection. Exp Opin Ther Pat; 19: 145-164.
    • (2009) Exp Opin Ther Pat , vol.19 , pp. 145-164
    • Beaulieu, P.L.1
  • 200
    • 57149142099 scopus 로고    scopus 로고
    • The exploding field of the HCV polymerase non-nucleoside inhibitors: Summary of a first generation compounds
    • Tramontano E., (2008) The exploding field of the HCV polymerase non-nucleoside inhibitors: summary of a first generation compounds. Mini Rev Med Chem; 8: 1298-1310.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 1298-1310
    • Tramontano, E.1
  • 201
    • 23944476834 scopus 로고    scopus 로고
    • Unravelling hepatitis C virus replication from genome to function
    • Lindenbach B.D., Rice C.M., (2005) Unravelling hepatitis C virus replication from genome to function. Nature; 436: 933-938.
    • (2005) Nature , vol.436 , pp. 933-938
    • Lindenbach, B.D.1    Rice, C.M.2
  • 202
    • 58749089998 scopus 로고    scopus 로고
    • New therapies for hepatitis C virus infection
    • Soriano V., Peters M.G., Zeuzem S., (2009) New therapies for hepatitis C virus infection. Clin Infect Dis; 48: 313-320.
    • (2009) Clin Infect Dis , vol.48 , pp. 313-320
    • Soriano, V.1    Peters, M.G.2    Zeuzem, S.3
  • 203
    • 47349093653 scopus 로고    scopus 로고
    • Non-nucleoside inhibitors of NS5B polymerase binding to allosteric sites: 3D QSAR and molecular docking studies
    • Cao H., Cao R., Zhang H., Zheng X., Gao D., (2008) Non-nucleoside inhibitors of NS5B polymerase binding to allosteric sites: 3D QSAR and molecular docking studies. Curr Med Chem; 15: 1462-1477.
    • (2008) Curr Med Chem , vol.15 , pp. 1462-1477
    • Cao, H.1    Cao, R.2    Zhang, H.3    Zheng, X.4    Gao, D.5
  • 206
    • 77955337993 scopus 로고    scopus 로고
    • Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus
    • Luo Y., Yao J., Yang L., Feng C., Tang W., Wang G., Zuo J., Lu W., (2010) Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus. Bioorg Med Chem; 18: 5048-5055.
    • (2010) Bioorg Med Chem , vol.18 , pp. 5048-5055
    • Luo, Y.1    Yao, J.2    Yang, L.3    Feng, C.4    Tang, W.5    Wang, G.6    Zuo, J.7    Lu, W.8
  • 208
    • 84355162873 scopus 로고    scopus 로고
    • Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase
    • Delang L., Froeyen M., Herdewijn P., Neyts J., (2012) Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase. Antiviral Res; 93: 30-38.
    • (2012) Antiviral Res , vol.93 , pp. 30-38
    • Delang, L.1    Froeyen, M.2    Herdewijn, P.3    Neyts, J.4
  • 213
    • 72049106897 scopus 로고    scopus 로고
    • Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization
    • Goulet S., Poupart M., Gillard J., Poirier M., Kukolj G., Beaulieu P.L., (2010) Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: implementing parallel synthesis for rapid linker optimization. Bioorg Med Chem Lett; 20: 196-200.
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 196-200
    • Goulet, S.1    Poupart, M.2    Gillard, J.3    Poirier, M.4    Kukolj, G.5    Beaulieu, P.L.6
  • 214
    • 0001947969 scopus 로고
    • Cytomegalovirus
    • Roizman B. Whitley R.J. Lopez C. editor. New York: Raven Press
    • Alford C.A., Britt W.J., (1993) Cytomegalovirus. In:, Roizman B., Whitley R.J., Lopez C., editor. The Human Herpesviruses. New York: Raven Press; p. 227-255.
    • (1993) The Human Herpesviruses , pp. 227-255
    • Alford, C.A.1    Britt, W.J.2
  • 215
    • 0018449607 scopus 로고
    • Cytomegalovirus: The troll of transplantation
    • Balfour H.H. Jr, (1979) Cytomegalovirus: the troll of transplantation. Arch Intern Med; 139: 279-280.
    • (1979) Arch Intern Med , vol.139 , pp. 279-280
    • Balfour, Jr.H.H.1
  • 216
    • 0029840904 scopus 로고    scopus 로고
    • Association between prior cytomegalovirus infection and the risk of restenosis after coronary atheroectomy
    • Zhou Y.F., Leon M.B., Waclawiw M.A., Popma J.J., Zu X.Y., Finkel T., Epstein S.E., (1996) Association between prior cytomegalovirus infection and the risk of restenosis after coronary atheroectomy. N Engl J Med; 335: 624-630.
    • (1996) N Engl J Med , vol.335 , pp. 624-630
    • Zhou, Y.F.1    Leon, M.B.2    Waclawiw, M.A.3    Popma, J.J.4    Zu, X.Y.5    Finkel, T.6    Epstein, S.E.7
  • 217
    • 0021814724 scopus 로고
    • Cytomegalovirus infection of the colon: A possible role in the exacerbations of inflammatory bowel disease
    • Berk T., Gordon S.J., Choi H.Y., Cooper H.S., (1985) Cytomegalovirus infection of the colon: a possible role in the exacerbations of inflammatory bowel disease. J Gastroenterol; 80: 355-360.
    • (1985) J Gastroenterol , vol.80 , pp. 355-360
    • Berk, T.1    Gordon, S.J.2    Choi, H.Y.3    Cooper, H.S.4
  • 218
    • 0030570951 scopus 로고    scopus 로고
    • Ganciclovir
    • Crumpacker C.S., (1996) Ganciclovir. N Engl J Med; 335: 721-729.
    • (1996) N Engl J Med , vol.335 , pp. 721-729
    • Crumpacker, C.S.1
  • 219
    • 0034933504 scopus 로고    scopus 로고
    • Valganciclovir
    • Curran M., Noble S., (2001) Valganciclovir. Drugs; 61: 1145-1150.
    • (2001) Drugs , vol.61 , pp. 1145-1150
    • Curran, M.1    Noble, S.2
  • 220
    • 0028853743 scopus 로고
    • Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(β-D-ribofuranosyl)benzimidazoles
    • Townsend L.B., Devivar R.V., Turk S.R., Nassiri M.R., Drach J.C., (1995) Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(β-D-ribofuranosyl)benzimidazoles. J Med Chem; 38: 4098-4105.
    • (1995) J Med Chem , vol.38 , pp. 4098-4105
    • Townsend, L.B.1    Devivar, R.V.2    Turk, S.R.3    Nassiri, M.R.4    Drach, J.C.5
  • 222
    • 0036720595 scopus 로고    scopus 로고
    • Phase i dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding
    • Lalezari J.P., Aberg J.A., Wang L.H., Wire M.B., Miner R., Snowden W., Talarico C.L., Shaw S., Jacobson M.A., Drew W.L., (2002) Phase I dose escalation trial evaluating the pharmacokinetics, anti-human cytomegalovirus (HCMV) activity, and safety of 1263W94 in human immunodeficiency virus-infected men with asymptomatic HCMV shedding. Antimicrob Agents Chemother; 46: 2969-2976.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2969-2976
    • Lalezari, J.P.1    Aberg, J.A.2    Wang, L.H.3    Wire, M.B.4    Miner, R.5    Snowden, W.6    Talarico, C.L.7    Shaw, S.8    Jacobson, M.A.9    Drew, W.L.10
  • 223
    • 0031058374 scopus 로고    scopus 로고
    • Design, synthesis, andantiviral evaluation of 2-chloro-5,6-dihalo-1-β-D-ribofuranosylbenzimidazolesas potential agents for human cytomegalovirus infections
    • Zou R., Drach J.C., Townsend L.B., (1997) Design, synthesis, andantiviral evaluation of 2-chloro-5,6-dihalo-1-β-D-ribofuranosylbenzimidazolesas potential agents for human cytomegalovirus infections. J Med Chem; 40: 811-818.
    • (1997) J Med Chem , vol.40 , pp. 811-818
    • Zou, R.1    Drach, J.C.2    Townsend, L.B.3
  • 224
    • 77952728889 scopus 로고    scopus 로고
    • Synthesis and antiulcer activity of 2-[5-substituted-1H-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H) ones
    • Patil A., Ganguly S., Surana S., (2010) Synthesis and antiulcer activity of 2-[5-substituted-1H-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H) ones. J Chem Sci; 122: 443-450.
    • (2010) J Chem Sci , vol.122 , pp. 443-450
    • Patil, A.1    Ganguly, S.2    Surana, S.3
  • 225
    • 77956246444 scopus 로고    scopus 로고
    • Synthesis and antiulcer activity of novel pyrimidylthiomethyl- and pyrimidylsulfinylmethyl benzimidazoles as potential reversible proton pump inhibitors
    • Bariwal J.B., Shah A.K., Kathiravan M.K., Somani R.S., Jagtap J.R., Jain K.S., (2008) Synthesis and antiulcer activity of novel pyrimidylthiomethyl- and pyrimidylsulfinylmethyl benzimidazoles as potential reversible proton pump inhibitors. Indian J Pharm Educ Res; 42: 225-231.
    • (2008) Indian J Pharm Educ Res , vol.42 , pp. 225-231
    • Bariwal, J.B.1    Shah, A.K.2    Kathiravan, M.K.3    Somani, R.S.4    Jagtap, J.R.5    Jain, K.S.6
  • 226
    • 84856022426 scopus 로고    scopus 로고
    • Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells
    • Chang C., Liu J., Lin H., Lin C., Tang C., Lue D., Sing Y., Chen L., Kao M., Kuo S., Lai C., (2012) Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. Eur J Med Chem; 48: 244-254.
    • (2012) Eur J Med Chem , vol.48 , pp. 244-254
    • Chang, C.1    Liu, J.2    Lin, H.3    Lin, C.4    Tang, C.5    Lue, D.6    Sing, Y.7    Chen, L.8    Kao, M.9    Kuo, S.10    Lai, C.11
  • 227
    • 84906250932 scopus 로고    scopus 로고
    • Synthesis and antiulcer, anti-secretory activity of some new substituted 2-(pyrimidinylsulfinyl) benzamidazoles derivatives
    • Khan F.A., Asnani A.J., (2011) Synthesis and antiulcer, anti-secretory activity of some new substituted 2-(pyrimidinylsulfinyl) benzamidazoles derivatives. Int J Res Pharm Biomed Sci; 2: 695-700.
    • (2011) Int J Res Pharm Biomed Sci , vol.2 , pp. 695-700
    • Khan, F.A.1    Asnani, A.J.2
  • 228
    • 84931261758 scopus 로고    scopus 로고
    • Anti-ulcerogeic effect of 2-(pyrimidinylsulfinyl) benzimidazole derivative against different ulcerogenic agents in rats
    • Khan F., Nadeem S., (2011) Anti-ulcerogeic effect of 2-(pyrimidinylsulfinyl) benzimidazole derivative against different ulcerogenic agents in rats. Pharmacologyonline; 2: 1217-1222.
    • (2011) Pharmacologyonline , vol.2 , pp. 1217-1222
    • Khan, F.1    Nadeem, S.2
  • 229
    • 84906214142 scopus 로고    scopus 로고
    • Synthesis and study of some novel benzimidazole analogs as potential antiulcer agents
    • Patil A., Ganguly S., Hundiwale J., Tayade S., (2012) Synthesis and study of some novel benzimidazole analogs as potential antiulcer agents. Int J Pharm Chem; 2: 89-92.
    • (2012) Int J Pharm Chem , vol.2 , pp. 89-92
    • Patil, A.1    Ganguly, S.2    Hundiwale, J.3    Tayade, S.4
  • 233
    • 0035430385 scopus 로고    scopus 로고
    • Do most antihypertensive agents have a sympatholytic action?
    • de Champlain J., (2001) Do most antihypertensive agents have a sympatholytic action? Curr Hypertens Rep; 3: 305-313.
    • (2001) Curr Hypertens Rep , vol.3 , pp. 305-313
    • De Champlain, J.1
  • 236
    • 84883456450 scopus 로고    scopus 로고
    • A rational design, synthesis, characterization, and antihypertensive activities of some new substituted benzimidazoles
    • Jain A., Sharma R., Chaturvedi S.C., (2013) A rational design, synthesis, characterization, and antihypertensive activities of some new substituted benzimidazoles. Med Chem Res; 22: 4622-4632.
    • (2013) Med Chem Res , vol.22 , pp. 4622-4632
    • Jain, A.1    Sharma, R.2    Chaturvedi, S.C.3
  • 238
    • 78649866242 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of some new benzimidazoles derivatives 4′-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1-ylmethyl}-biphenyl-2-carboxylic acid: Nonpeptide angiotensin II receptor antagonists
    • Sharma M.C., Kohli D.V., Sharma S., (2010) Synthesis and biological evaluation of some new benzimidazoles derivatives 4′-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1-ylmethyl}-biphenyl-2-carboxylic acid: nonpeptide angiotensin II receptor antagonists. Int J Drug Deliv; 2: 265-277.
    • (2010) Int J Drug Deliv , vol.2 , pp. 265-277
    • Sharma, M.C.1    Kohli, D.V.2    Sharma, S.3
  • 239
    • 77957125793 scopus 로고    scopus 로고
    • Synthesis of benzimidazole derivatives: As anti-hypertensive agents
    • Rakeshkumar J., Jawahar J., Pathak D.P., (2006) Synthesis of benzimidazole derivatives: as anti-hypertensive agents. Eur J Chem; 3: 278-285.
    • (2006) Eur J Chem , vol.3 , pp. 278-285
    • Rakeshkumar, J.1    Jawahar, J.2    Pathak, D.P.3
  • 240
    • 62549101320 scopus 로고    scopus 로고
    • Synthesis and antiparasitic and antifungal evaluation of 2′-arylsubstituted-1H, 10H-[2,5′]bisbenzimidazolyl-5-carboxamidines
    • Alp M., Goker H., Brun R., Ybox drawings light down and leftldbox drawings light down and leftz S., (2009) Synthesis and antiparasitic and antifungal evaluation of 2′-arylsubstituted-1H, 10H-[2,5′]bisbenzimidazolyl-5-carboxamidines. Eur J Med Chem; 44: 2002-2008.
    • (2009) Eur J Med Chem , vol.44 , pp. 2002-2008
    • Alp, M.1    Goker, H.2    Brun, R.3    Yildiz, S.4
  • 242
    • 83155175541 scopus 로고    scopus 로고
    • Synthesis and biological activity of benzimidazoles
    • Radha Y., Manjula K.M., Reddy B.M., Rao B.V., (2011) Synthesis and biological activity of benzimidazoles. Ind J Chem; 50B: 1762-1773.
    • (2011) Ind J Chem , vol.50 B , pp. 1762-1773
    • Radha, Y.1    Manjula, K.M.2    Reddy, B.M.3    Rao, B.V.4
  • 244
    • 0035931486 scopus 로고    scopus 로고
    • Novel N-ferrocenylmethyl, N-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the P. Falciparum malarial parasite strain NF54
    • Howarth J., Hanlon K., (2001) Novel N-ferrocenylmethyl, N-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the P. falciparum malarial parasite strain NF54. Tetrahedron Lett; 42: 751-754.
    • (2001) Tetrahedron Lett , vol.42 , pp. 751-754
    • Howarth, J.1    Hanlon, K.2
  • 246
    • 84863990364 scopus 로고    scopus 로고
    • Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation
    • Ongarora D.S.B., Gut J., Rosenthal P.J., Masimirembwa C.M., Chibale K., (2012) Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorg Med Chem Lett; 22: 5046-5050.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 5046-5050
    • Ongarora, D.S.B.1    Gut, J.2    Rosenthal, P.J.3    Masimirembwa, C.M.4    Chibale, K.5
  • 249
    • 84878606613 scopus 로고    scopus 로고
    • Rational design, synthesis and QSAR study of vasorelaxant active 3-pyridinecarbonitriles incorporating 1H-benzimidazol-2-yl function
    • Nofal Z.M., Srour A.M., El-Eraky W.I., Saleh D.O., Girgis A.S., (2013) Rational design, synthesis and QSAR study of vasorelaxant active 3-pyridinecarbonitriles incorporating 1H-benzimidazol-2-yl function. Eur J Med Chem; 63: 14-21.
    • (2013) Eur J Med Chem , vol.63 , pp. 14-21
    • Nofal, Z.M.1    Srour, A.M.2    El-Eraky, W.I.3    Saleh, D.O.4    Girgis, A.S.5
  • 250
    • 84874017261 scopus 로고    scopus 로고
    • Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones
    • Di Braccio M., Grossi G., Signorello M.G., Leoncini G., Cichero E., Fossa P., Alfei S., Damonte G., (2013) Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones. Eur J Med Chem; 62: 564-578.
    • (2013) Eur J Med Chem , vol.62 , pp. 564-578
    • Di Braccio, M.1    Grossi, G.2    Signorello, M.G.3    Leoncini, G.4    Cichero, E.5    Fossa, P.6    Alfei, S.7    Damonte, G.8
  • 251
    • 0002630825 scopus 로고
    • Neuromuscular transmission-enzymatic destruction of acetylcholine
    • Hubbard J.I. editor. New York: Plenum Press
    • Barnard E.A., (1974) Neuromuscular transmission-enzymatic destruction of acetylcholine. In:, Hubbard J.I., editor. The Peripheral Nervous System. New York: Plenum Press; p. 201-224.
    • (1974) The Peripheral Nervous System , pp. 201-224
    • Barnard, E.A.1
  • 252
    • 0036548851 scopus 로고    scopus 로고
    • Alzheimer's disease: An overview of current and emerging therapeutic strategies
    • Jacobsen J.S., (2002) Alzheimer's disease: an overview of current and emerging therapeutic strategies. Curr Top Med Chem; 2: 343-352.
    • (2002) Curr Top Med Chem , vol.2 , pp. 343-352
    • Jacobsen, J.S.1
  • 253
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., Selkoe D.J., (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science; 297: 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 254
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol; 30: 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3
  • 255
    • 84881371708 scopus 로고    scopus 로고
    • Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors
    • Alpan A.S., Parlar S., Carlino L., Tarikogullari A.H., Alptüzün V., Semih Günes H., (2013) Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem; 21: 4928-4937.
    • (2013) Bioorg Med Chem , vol.21 , pp. 4928-4937
    • Alpan, A.S.1    Parlar, S.2    Carlino, L.3    Tarikogullari, A.H.4    Alptüzün, V.5    Semih Günes, H.6
  • 256
    • 84879023330 scopus 로고    scopus 로고
    • Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase
    • Zhu J., Wu C., Li X., Wu G., Xie S., Hu Q., Deng Z., Zhu M.X., Luo H., Hong X., (2013) Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem; 21: 4218-4224.
    • (2013) Bioorg Med Chem , vol.21 , pp. 4218-4224
    • Zhu, J.1    Wu, C.2    Li, X.3    Wu, G.4    Xie, S.5    Hu, Q.6    Deng, Z.7    Zhu, M.X.8    Luo, H.9    Hong, X.10
  • 257
    • 84885091255 scopus 로고    scopus 로고
    • Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors
    • Yoon Y.K., Ali M.A., Wei A.C., Choon T.S., Khaw K., Murugaiyah V., Osman H., Masand V.H., (2013) Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors. Bioorg Chem; 49: 33-39.
    • (2013) Bioorg Chem , vol.49 , pp. 33-39
    • Yoon, Y.K.1    Ali, M.A.2    Wei, A.C.3    Choon, T.S.4    Khaw, K.5    Murugaiyah, V.6    Osman, H.7    Masand, V.H.8
  • 258
    • 84877828246 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease
    • Matsumura K., Ono M., Yoshimura M., Kimura H., Watanabe H., Okamoto Y., Ihara M., Takahashi R., Saji H., (2013) Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease. Bioorg Med Chem; 21: 3356-3362.
    • (2013) Bioorg Med Chem , vol.21 , pp. 3356-3362
    • Matsumura, K.1    Ono, M.2    Yoshimura, M.3    Kimura, H.4    Watanabe, H.5    Okamoto, Y.6    Ihara, M.7    Takahashi, R.8    Saji, H.9
  • 259
    • 84874664127 scopus 로고    scopus 로고
    • Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization
    • Matter H., Zoller G., Herling A.W., Sanchez-Arias J., Philippo C., Namane C., Kohlmann M., Pfenninger A., Voss M.D., (2013) Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization. Bioorg Med Chem Lett; 23: 1817-1822.
    • (2013) Bioorg Med Chem Lett , vol.23 , pp. 1817-1822
    • Matter, H.1    Zoller, G.2    Herling, A.W.3    Sanchez-Arias, J.4    Philippo, C.5    Namane, C.6    Kohlmann, M.7    Pfenninger, A.8    Voss, M.D.9
  • 260
    • 84875737494 scopus 로고    scopus 로고
    • Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects
    • Kim M., Lee J., Jung K., Kim M., Park Y., Ahn H., Kwon Y.H., Hah J., (2013) Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects. Bioorg Med Chem; 21: 2271-2285.
    • (2013) Bioorg Med Chem , vol.21 , pp. 2271-2285
    • Kim, M.1    Lee, J.2    Jung, K.3    Kim, M.4    Park, Y.5    Ahn, H.6    Kwon, Y.H.7    Hah, J.8
  • 261
    • 84885184350 scopus 로고    scopus 로고
    • Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position
    • Vlahakis J.Z., Vukomanovic D., Nakatsu K., Szarek W.A., (2013) Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): exploration of the effects of substituents at the N-1 position. Bioorg Med Chem; 21: 6788-6795.
    • (2013) Bioorg Med Chem , vol.21 , pp. 6788-6795
    • Vlahakis, J.Z.1    Vukomanovic, D.2    Nakatsu, K.3    Szarek, W.A.4
  • 263
  • 264
    • 84890114835 scopus 로고    scopus 로고
    • Discovery of a benzimidazole series of ADAMTS-5 (Aggrecanase-2) inhibitors by scaffold hopping
    • Sogame S., Suenaga Y., Atobe M., Kawanishi M., Tanaka E., Miyoshi S., (2014) Discovery of a benzimidazole series of ADAMTS-5 (Aggrecanase-2) inhibitors by scaffold hopping. Eur J Med Chem; 71: 250-258.
    • (2014) Eur J Med Chem , vol.71 , pp. 250-258
    • Sogame, S.1    Suenaga, Y.2    Atobe, M.3    Kawanishi, M.4    Tanaka, E.5    Miyoshi, S.6
  • 267
    • 84883489738 scopus 로고    scopus 로고
    • Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors
    • Hofer S., Kratschmar D.V., Schernthanner B., Vuorinen A., Schuster D., Odermatt A., Easmon J., (2013) Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem; 23: 5397-5400.
    • (2013) Bioorg Med Chem , vol.23 , pp. 5397-5400
    • Hofer, S.1    Kratschmar, D.V.2    Schernthanner, B.3    Vuorinen, A.4    Schuster, D.5    Odermatt, A.6    Easmon, J.7
  • 269
    • 84868541855 scopus 로고    scopus 로고
    • Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators
    • Bischoff F., Berthelot D., De Cleyn M., Macdonald G., Minne G., Oehlrich D., Pieters S., et al,. (2012) Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators. J Med Chem; 55: 9089-9106.
    • (2012) J Med Chem , vol.55 , pp. 9089-9106
    • Bischoff, F.1    Berthelot, D.2    De Cleyn, M.3    MacDonald, G.4    Minne, G.5    Oehlrich, D.6    Pieters, S.7
  • 271
    • 84865139102 scopus 로고    scopus 로고
    • Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles
    • Tamura Y., Omori N., Kouyama N., Nishiura Y., Hayashi K., Watanabe K., Tanaka Y., Chiba T., Yukioka H., Sato H., Okuno T., (2012) Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles. Bioorg Med Chem Lett; 22: 5498-5502.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 5498-5502
    • Tamura, Y.1    Omori, N.2    Kouyama, N.3    Nishiura, Y.4    Hayashi, K.5    Watanabe, K.6    Tanaka, Y.7    Chiba, T.8    Yukioka, H.9    Sato, H.10    Okuno, T.11
  • 273
    • 84862803977 scopus 로고    scopus 로고
    • Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine
    • Wu Z., Yang C., Xiong Y., Feng Z., Lombardo M., Verras A., Chabin R.M., et al,. (2012) Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine. Bioorg Med Chem Lett; 22: 1774-1778.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 1774-1778
    • Wu, Z.1    Yang, C.2    Xiong, Y.3    Feng, Z.4    Lombardo, M.5    Verras, A.6    Chabin, R.M.7
  • 274
    • 84861573030 scopus 로고    scopus 로고
    • Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)
    • Banoglu E., Calbox drawings light down and leftskan B., Luderer S., Eren G., Ozkan Y., Altenhofen W., Weinigel C., Barz D., Gerstmeier J., Pergola C., Werz O., (2012) Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). Bioorg Med Chem; 20: 3728-3741.
    • (2012) Bioorg Med Chem , vol.20 , pp. 3728-3741
    • Banoglu, E.1    Caliskan, B.2    Luderer, S.3    Eren, G.4    Ozkan, Y.5    Altenhofen, W.6    Weinigel, C.7    Barz, D.8    Gerstmeier, J.9    Pergola, C.10    Werz, O.11
  • 275
    • 84865125787 scopus 로고    scopus 로고
    • 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors
    • Hua Z., Huang X., Bregman H., Chakka N., DiMauro E.F., Doherty E.M., Goldstein J., et al,. (2012) 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors. Bioorg Med Chem Lett; 22: 5392-5395.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 5392-5395
    • Hua, Z.1    Huang, X.2    Bregman, H.3    Chakka, N.4    Dimauro, E.F.5    Doherty, E.M.6    Goldstein, J.7
  • 277
    • 80053417413 scopus 로고    scopus 로고
    • Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility
    • Cosimelli B., Taliani S., Greco G., Novellino E., Sala A., Severi E., Da Settimo F., et al,. (2011) Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility. Chem Med Chem; 6: 1909-1918.
    • (2011) Chem Med Chem , vol.6 , pp. 1909-1918
    • Cosimelli, B.1    Taliani, S.2    Greco, G.3    Novellino, E.4    Sala, A.5    Severi, E.6    Da Settimo, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.