Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3762-3769

  Moriarty, Eoin ^a   Carr, Miriam ^a   Bonham, Sarah ^a   Carty, Michael P ^a   Aldabbagh, Fawaz ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Bioreductive; Heterocyclic compounds; NQO1; Quinones

Indexed keywords

1 ALLYL 2 (1 BROMO 2 NAPHTHYL) 1H BENZIMIDAZOLE; 1 ALLYL 2 (1 BROMO 2 NAPHTHYL) 4,7 DIMETHOXY 1H BENZIMIDAZOLE; 1 ALLYL 2 (2 BROMOPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 1 ALLYL 2 (2 BROMOPYRIDIN 3 YL) 4,7 DIMETHOXY 1H BENZIMIDAZOLE; 1 ETHYL 2 (2 NAPHTHYL) 1H BENZIMIDAZOLE 4,7 DIONE; 1 ETHYL 2 PHENYL 1H BENZIMIDAZOLE 4,7 DIONE; 1 ETHYL 2 PYRIDIN 3 YL 1H BENZIMIDAZOLE 4,7 DIONE; 1 ETHYL 4,7 DIMETHOXY 2 (2 NAPHTHYL) 1H BENZIMIDAZOLE; 1 ETHYL 4,7 DIMETHOXY 2 PHENYL 1H BENZIMIDAZOLE; 1 ETHYL 4,7 DIMETHOXY 2 PYRIDIN 3 YL 1H BENZIMIDAZOLE; 2 (1 BROMO 2 NAPHTHYL) 1H BENZIMIDAZOLE; 2 (1 BROMO 2 NAPHTHYL) 4,7 DIMETHOXY 1H BENZIMIDAZOLE; 2 (2 BROMOPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 2 (2 BROMOPYRIDIN 3 YL) 4,7 DIMETHOXY 1H BENZIMIDAZOLE; 4,7 DIMETHOXY 2 (2 NAPHTHYL) 1H BENZIMIDAZOLE; 5 METHYL 5,6 DIHYDROBENZIMIDAZO[2,1 A]BENZO[F]ISOQUINOLINE 8,11 DIONE; 5 METHYL 5,6 DIHYDROBENZIMIDAZO[2,1 F] 1,6 NAPHTHYRIDINE; 5 METHYL 5,6 DIHYDROBENZIMIDAZO[2,1 F] 1,6 NAPHTHYRIDINE 8,11 DIONE; 8,11 DIMETHOXY 5 METHYL 5,6 DIHYDROBENZIMIDAZO[2,1 A]BENZO[F]ISOQUINOLINE; 8,11 DIMETHOXY 5 METHYL 5,6 DIHYDROBENZIMIDAZO[2,1 F] 1,6 NAPHTHYRIDINE; BENZIMIDAZOLE DERIVATIVE; MITOMYCIN C; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MALE; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; HYDROCARBONS, AROMATIC; INHIBITORY CONCENTRATION 50;

EID: 77955557677     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.025     Document Type: Article

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