Synthesis and in-silico molecular docking simulation of 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones as novel analgesic anti-inflammatory agent

Arabian Journal of Chemistry

Volumn 9, Issue , 2016, Pages S1779-S1785

  Chhajed, Santosh S ^a   Upasani, Chandrashekhar D ^a  

^a SSDJ College of Pharmacy   (India)

Author keywords

2 Azetidinones; Analgesic; Anti inflammatory; COX II; Molecular docking

Indexed keywords

BINDING ENERGY; BINDING SITES; BINS;

2-AZETIDINONES; ANALGESIC; ANTI-INFLAMMATORIES; COX-II; MOLECULAR DOCKING;

MOLECULAR MODELING;

EID: 85028253989     PISSN: 18785352     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arabjc.2012.04.038     Document Type: Article

References (17)

1. Agarwal, R., Agarwal, C., Singh, C., Mishra, V., Synthesis of sulpha drug quinazolin -4-one derivatives and their evaluation for anti-inflammatory activity. Ind. J. Chem. 28B (1989), 893–896.
2. Charlson, A., The anti-inflammatory and analgesic activity of some benzimidazoles, and their ability to protect erythrocytes from hemolysis by silica powder. Carbo. Re. 43 (1975), 383–387.
3. Chhajed, S., Bastikar, V., Haldar, A., Upasani, C., Synthesis and molecular modeling studies of 3-chloro-4-substituted-1-(8-hydroxy-quinolin-5-yl)-azetidin-2-ones as novel anti-filarial agents. Biol. Med. Chem. Lett. 20 (2010), 3640–3644.
4. Hazelton, J., Iddon, B., Suschitzky, H., Wolley, L., 2H-benzimidazoles (isobenzimidazoles). Part 10: Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted benzimidazoles with known or potential anthelminthic activity. Tetr. 51 (1995), 10771–10794.
5. Kavitha, C., Kallappa, M., Harisha, R., Seetharamareddy. In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives. Eur. J. Med. Chem. 45:5 (2010), 2048–2054.
6. Kazimierczuk, Z., Andrzejewska, M., Kaustova, J., Klimesova, V., Synthesis and antimycobacterial activity of 2-substituted halogenobenzimidazoles. Eur. J. Med. Chem. 40:2 (2005), 203–208.
7. Kelsey, C., Duggan, K., Walters, Musee, J., Harp, J., Kiefer, J., Oates, J., Marnett, L.J., Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. Biol. Chem. 285 (2010), 34950–34959.
8. 2-antagonists. Drug Dev. Res. 8 (1986), 133–140.
9. Koster, R., Anderson, M., Acetic acid for analgesic screening. Proc. Soc. Exp. Biol. 18 (1959), 412–415.
10. Kozo, A., Kazuhiro, A., Masayuki, K., Yongzhe, Y., US 6815, 455, 2001; Chem. Abstr. 2001, 134, 86247.
11. Langtry, D., Wilde, M., Omeprazole: A review of its use in helicobacter pylori infection, gastro-oesophageal reflux disease and peptic ulcers induced by nonsteroidal anti-inflammatory drugs. Drugs 56 (1998), 447–486.
12. Meisel, P., Heidrich, H., Kretzschmar, E., Henker, S., Laban, G., Chem. Abstr., 107, 1987, 217629.
13. Sondhi, S., Johar, M., Neelam, B., Azam, A., Singh, A., Anti-inflammatory, analgesic and antiamoebic activity evaluation of pyrimido[1,6-a]benzimidazole derivatives synthesized by the reaction of ketoisothiocyanates with mono and diamines. Eur. J. Med. Chem. 10:37 (2002), 835–843.
14. Sondhi, S., Johar, M., Neelam, B., Azam, A., Singh, A., Lozachc, O., Laurent, M., Biol. Med. Chem. 14 (2006), 3758–3765.
15. Srivastava, S., Srivastava, S., Srivastava, S., Ind. J. Chem. 39B (2000), 464–467.
16. Winter, C., Risley, E., Nuss, G., Carrageenan induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. 111 (1962), 544–547.
17. Zheng, X., Oda, H., Takamatsu, K., Yukio, S., Eiichi, A., Hamed, I., Toshiyuki, O., Hiroki, K., Biol. Med. Chem. 15 (2007), 1014–1021.