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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5498-5502

Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles

(11) Tamura, Yuusuke a Omori, Naoki a Kouyama, Naoki a Nishiura, Yuji a Hayashi, Kyouhei a Watanabe, Kana a Tanaka, Yukari a Chiba, Takeshi a Yukioka, Hideo a Sato, Hiroki a Okuno, Takayuki a

a SHIONOGI AND CO LTD (Japan)

Author keywords

Benzimidazole; NPY Y5 receptor antagonist; Obesity; Pyridone

Indexed keywords

ALBENDAZOLE; BENZIMIDAZOLE DERIVATIVE; DIPYRONE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y5 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR ANTAGONIST; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VELNEPERIT;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; HYDROGENATION; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR INTERACTION; REACTION OPTIMIZATION; RECEPTOR BINDING;

ANIMALS; BENZIMIDAZOLES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; HUMANS; MICE; MICROSOMES, LIVER; OBESITY; PYRIDONES; RATS; RECEPTORS, NEUROPEPTIDE Y;

EID: 84865139102 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.07.020 Document Type: Article

Times cited : (24)

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