Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria

ACS Medicinal Chemistry Letters

Volumn 2, Issue 9, 2011, Pages 708-713

  Skerlj, Renato T ^a   Bastos, Cecilia M ^a   Booker, Michael L ^a   Kramer, Martin L ^a   Barker, Robert H ^a   Celatka, Cassandra A ^a   O'Shea, Thomas J ^a   Munoz, Benito ^b   Sidhu, Amar Bir ^b   Cortese, Joseph F ^b   Wittlin, Sergio ^c,d   Papastogiannidis, Petros ^c,d   Angulo Barturen, Inigo ^e   Jimenez Diaz, Maria Belen ^e   Sybertz, Edmund ^a  

^a GENZYME CORPORATION   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e GLAXOSMITHKLINE   (Spain)

Author keywords

DHODH; drug candidate; malaria; P. falciparum

Indexed keywords

5 (2 METHYLBENZIMIDAZOL 1 YL) 1 ALKYLTHIOPHENE 2 CARBOXAMIDE; 5 (4 CYANO 2 METHYL 1H BENZO[D]IMIDAZOL 1 YL) N CYCLOPROPYLTHIOPHENE 2 CARBOXAMIDE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; DRUG EFFICACY; DRUG INTERACTION; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RISK ASSESSMENT; STRUCTURE ACTIVITY RELATION;

PLASMODIUM FALCIPARUM; RODENTIA;

EID: 80052624721     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200143c     Document Type: Article

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