Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 15, 2012, Pages 5046-5050

  Ongarora, Dennis S B ^a   Gut, Jiri ^b   Rosenthal, Philip J ^b   Masimirembwa, Collen M ^c   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c African Institute of Biomedical Science and Technology   (Zimbabwe)

Author keywords

Amodiaquine; Antiplasmodial; Benzoheterocyclic; Benzothiazole; Benzoxazole; Quinone imine; Reactive metabolite

Indexed keywords

AMODIAQUINE; BENZIMIDAZOLE; BENZOTHIAZOLE; BENZOXAZOLE DERIVATIVE; CHLOROQUINE; HETEROCYCLIC COMPOUND; PYRIDINE DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; PROTON TRANSPORT;

AMODIAQUINE; ANIMALS; ANTIMALARIALS; BENZIMIDAZOLES; BENZOTHIAZOLES; BENZOXAZOLES; CELL LINE; DRUG RESISTANCE, MICROBIAL; HETEROCYCLIC COMPOUNDS; PLASMODIUM FALCIPARUM; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 84863990364     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.010     Document Type: Article

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