Synthesis of potential anticancer derivatives of pyrido[1,2-a] benzimidazoles

Medicinal Chemistry Research

Volumn 21, Issue 7, 2012, Pages 1253-1260

  Refaat, Hanan M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

1 chloro 4 cyanopyrido 1,2 a benzimidazoles; 4 cyano 1 (4 (2 fluorophenyl)piperazin yl) 3 methylpyrido 1,2 a benzimidazoles; 4 cyano 1 oxo pyrido 1,2 a benzimidazoles; Anticancer

Indexed keywords

1 CHLORO 4 CYANO 2 (2 CHLOROETHYL) 3 METHYL PYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 1 CHLORO 4 CYANO 3 METHYLPYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 1 CHLORO 4 CYANO 3 PHENYLPYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 1,8 DICHLORO 4 CYANO 2 (2 CHLOROETHYL) 3 METHYLPYRIDO[1,2 A]BENZIMIDAZOLE; 1,8 DICHLORO 4 CYANO 3 METHYLPYRIDO[1,2 A]BENZIMIDAZOLE; 1,8 DICHLORO 4 CYANO 3 PHENYLPYRIDO[1,2 A]BENZIMIDAZOLE; 4 CYANO 1 [4 (2 FLUOROPHENYL)PIPERAZIN YL] 2 [2 [4 (2 FLUOROPHENYL)PIPERAZIN YL]ETHYL] 3 METHYL PYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 4 CYANO 1 [4 (2 FLUOROPHENYL)PIPERAZIN YL] 3 METHYLPYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 4 CYANO 1 [4 (2 FLUOROPHENYL)PIPERAZIN YL] 3 PHENYLPYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 4 CYANO 2 (2 HYDROXYETHYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 4 CYANO 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 4 CYANO 3 PHENYL 1 OXO 1H,5H PYRIDO[1,2-A]BENZIMIDAZOLE 8 CARBOXYLIC ACID; 8 CHLORO 4 CYANO 1 [4 (2 FLUOROPHENYL)PIPERAZIN YL] 2 [2 [4 (2 FLUOROPHENYL)PIPERAZIN YL]ETHYL] 3 METHYLPYRIDO[1,2 A]BENZIMIDAZOLE; 8 CHLORO 4 CYANO 1 [4 (2 FLUOROPHENYL)PIPERAZIN YL] 3 METHYLPYRIDO[1,2 A]BENZIMIDAZOLE; 8 CHLORO 4 CYANO 1[4 (2 FLUOROPHENYL)PIPERAZIN YL] 3 PHENYLPYRIDO[1,2 A]BENZIMIDAZOLE; 8 CHLORO 4 CYANO 2 (2 HYDROXYETHYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE; 8 CHLORO 4 CYANO 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE; 8 CHLORO 4 CYANO 3 PHENYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE; ANTINEOPLASTIC AGENT; DOXORUBICIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 84861857801     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9636-y     Document Type: Article

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