Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1859-1863

  Ishida, Tomio ^a   Suzuki, Takayoshi ^a,b   Hirashima, Shintaro ^a   Mizutani, Kenji ^a   Yoshida, Atsuhito ^a   Ando, Izuru ^a   Ikeda, Satoru ^a   Adachi, Tsuyoshi ^a   Hashimoto, Hiromasa ^a  

^a JAPAN TOBACCO INC   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Benzimidazole; HCV; Inhibitor; NS5B polymerase

Indexed keywords

ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; DNA POLYMERASE; RNA DIRECTED RNA POLYMERASE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HEPATITIS C VIRUS; IC 50; RNA REPLICATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS INHIBITION; VIRUS REPLICATION;

BENZIMIDAZOLES; ENZYME INHIBITORS; HEPACIVIRUS; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 33144486131     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.032     Document Type: Article

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26. The biphenyl type of compounds 24e is also attractive for further study. The results will be reported in due course.