Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1702-1710

  Monforte, Anna Maria ^a   Logoteta, Patrizia ^a   Luca, Laura De ^a   Iraci, Nunzio ^b   Ferro, Stefania ^a   Maga, Giovanni ^c   De Clercq, Erik ^d   Pannecouque, Christophe ^d   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c CNR   (Italy)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1,3 Dihydro benzimidazol 2 ones; HIV 1 reverse transcriptase; Molecular modeling; Synthesis

Indexed keywords

6 CHLORO 1 (2 METHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (2,3,4,5,6 PENTAMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (2,3,5,6 TETRAMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (2,4 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (2,4,6 TRIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (2,5 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3 METHOXYPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3 METHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3 TRIFLUOROMETHOXYPHENYLSULFONYL) 1,3 DIHYRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3 TRIFLUOROMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3,4 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3,5 BISTRIFLUOROMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3,5 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3,5 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 THIONE; 6 CHLORO 1 (3,5 DIMETHYLPHENYLSULFONYL) 1H IMIDAZO[4,5 B]PYRIDIN 2(3H) ONE; 6 CHLORO 1(4 METHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; AMINO ACID; BENZIMIDAZOLE DERIVATIVE; EFAVIRENZ; METHYL GROUP; NEVIRAPINE; PHENYL GROUP; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MOLECULAR MODEL; MUTATION; VIRUS REPLICATION;

BENZIMIDAZOLES; CELL LINE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 75849125916     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.059     Document Type: Article

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