Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4713-4718

  Kwak, Hyun Jung ^a   Pyun, Yu Mi ^b   Kim, Ji Young ^a,c   Pagire, Haushabhau S ^a,c   Kim, Ki Young ^a   Kim, Kwang Rok ^a   Rhee, Sang Dal ^a   Jung, Won Hoon ^a   Song, Jin Sook ^a   Bae, Myung Ae ^a   Lee, Duck Hyung ^b   Ahn, Jin Hee ^a,c  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Sogang University   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

Author keywords

Aminobenzimidazole; DGAT 1; Diabetes; Diacylglycerol acyltransferase 1; Obesity; TG; Triglycerides

Indexed keywords

ACETIC ACID DERIVATIVE; ACYLTRANSFERASE INHIBITOR; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; BENZIMIDAZOLE DERIVATIVE; DIACYLGLYCEROL ACYLTRANSFERASE 1; POTASSIUM CHANNEL HERG;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SAFETY; DRUG SELECTIVITY; DRUG SYNTHESIS; EVALUATION; FAT TOLERANCE TEST; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; OBESITY; TOXICITY TESTING;

AMINOBENZIMIDAZOLE; DGAT-1; DIABETES; DIACYLGLYCEROL ACYLTRANSFERASE-1; OBESITY; TG; TRIGLYCERIDES;

ACETIC ACID; ANIMALS; ANTI-OBESITY AGENTS; BENZIMIDAZOLES; CELLS, CULTURED; CYCLIZATION; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; HUMANS; HYPOGLYCEMIC AGENTS; LIVER; MICE; MOLECULAR STRUCTURE; OBESITY;

EID: 84880578938     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.081     Document Type: Article

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