SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 2930-2935

  Jadhav, Ganesh Rajaram ^a,b   Shaikh, Mohammad Usman ^b   Kale, Rajesh Prabhakar ^b   Shiradkar, Mahendra Ramesh ^c   Gill, Charansingh Harnamsingh ^a  

^a DR BABASAHEB AMBEDKAR MARATHWADA UNIVERSITY   (India)

^b Wockhardt Research Centre   (India)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

1,2,4 Triazole; Air oxidation; Alkylation; Antibacterial activity; Antimycobacterial; Difluorobenzimidazole

Indexed keywords

2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 (2 METHYLBENZYL) 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 (3 CHLOROBENZYL) 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 (3 FLUOROBENZYL) 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 (3 METHOXYBENZYL) 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 (3 METHYLBENZYL) 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 (4 FLUOROBENZYL) 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 [3 (TRIFLUOROMETHYL) BENZYL] 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 ALLYL 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 BENZYL 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 1 ETHYL 4,6 DIFLUORO 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 4,6 DIFLUORO 1 (PROP 2 YNYL) 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 4,6 DIFLUORO 1 (TOSYLMETHYL) 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 4,6 DIFLUORO 1 METHYL 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 4,6 DIFLUORO 1 PROPYL 1H BENZO[D]IMIDAZOLE; 2 [4 (1H [1,2,4] TRIAZOL 1 YL)PHENYL] 4,6 DIFLUORO 1H BENZO [D]IMIDAZOLE 1 ACETONITRILE; ANTIINFECTIVE AGENT; FLUOROBENZIMIDAZOLE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ALKYLATION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BROTH DILUTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; ANTITUBERCULAR AGENTS; BENZIMIDAZOLES; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 67349280375     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.001     Document Type: Article

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