Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3147-3151

  Torres Gómez, Héctor ^a   Hernández Núñez, Emanuel ^a   León Rivera, Ismael ^b   Guerrero Alvarez, Jorge ^b   Cedillo Rivera, Roberto ^c   Moo Puc, Rosa ^c   Argotte Ramos, Rocío ^d   Carmen Rodríguez Gutiérrez, María del ^d   Chan Bacab, Manuel Jesús ^e   Navarrete Vázquez, Gabriel ^a  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

^d INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^e UNIVERSIDAD AUTÓNOMA DE CAMPECHE   (Mexico)

Author keywords

Antiprotozoal; Benzimidazole; Bioisosteric replacement; Entamoeba; Giardia; Pentamidine; Trichomonas

Indexed keywords

1,5 BIS[4 (5 METHOXY 1H BENZIMIDAZOLE 2 YL)PHENOXYL]PENTANE; BENZIMIDAZOLE; METRONIDAZOLE; PENTAMIDINE; PENTANE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; GIARDIA LAMBLIA; IN VITRO STUDY; LEISHMANIA MEXICANA; NONHUMAN; PLASMODIUM BERGHEI; PROTON NUCLEAR MAGNETIC RESONANCE; PROTOZOON; TRICHOMONAS VAGINALIS;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; DRUG DESIGN; ENTAMOEBA HISTOLYTICA; GIARDIA LAMBLIA; INHIBITORY CONCENTRATION 50; LEISHMANIA MEXICANA; METRONIDAZOLE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PENTAMIDINE; PLASMODIUM BERGHEI; STRUCTURE-ACTIVITY RELATIONSHIP; TRICHOMONAS VAGINALIS;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA; GIARDIA; GIARDIA INTESTINALIS; LEISHMANIA MEXICANA; PLASMODIUM BERGHEI; PROTOZOA; TRICHOMONAS; TRICHOMONAS VAGINALIS;

EID: 44249094176     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.009     Document Type: Article

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