Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 1978-1982

  Ushiroda, Kantaro ^a   Maruta, Katsunori ^a   Takazawa, Takeshi ^a   Nagano, Tomokazu ^a   Taiji, Mutsuo ^a   Kohno, Tetsuya ^a   Sato, Yasuhiro ^a   Horai, Shinji ^a   Yanagi, Kazunori ^a   Nagata, Ryu ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

PPAR agonist; PPAR partial agonist

Indexed keywords

2 (4 TOLUOYL)IMIDAZOLE; 3 (HYDROXYMETHYL)PHENOL; 4,5,6,7 TETRAHYDROBENZIMIDAZOLE; 5,6,7,8 TETRAHYDROBENZIMIDAZOLE; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; BENZOYLAZOLE DERIVATIVE; CARBOXYLIC ACID; DIMETHYLIMIDAZOLE; IMIDAZOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PYRROLE DERIVATIVE; SODIUM; TERT BUTYL 2 BROMO 2 METHYLPROPANOATE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ALKYLATION; ALLYLATION; ARTICLE; CHEMICAL REACTION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; IN VIVO STUDY; NONHUMAN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZOLES; HUMANS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; MICE; MODELS, ANIMAL; MODELS, MOLECULAR; PPAR ALPHA; PPAR GAMMA;

ANIMALIA;

EID: 79952489444     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.032     Document Type: Article

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