Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl) xanthines as potent and selective A2B adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 797-811

  Baraldi, Pier Giovanni ^a   Baraldi, Stefania ^a   Saponaro, Giulia ^a   Preti, Delia ^a   Romagnoli, Romeo ^a   Piccagli, Laura ^a   Cavalli, Andrea ^a   Recanatini, Maurizio ^a   Moorman, Allan R ^b   Zaid, Abdel Naser ^c   Varani, Katia ^a   Borea, Pier Andrea ^a   Tabrizi, Mojgan Aghazadeh ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b King Pharmaceuticals Inc   (United States)

^c AN NAJAH NATIONAL UNIVERSITY   (Palestine)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIPROPYL 8 (3 BENZIMIDAZOL 2 YL METHOXY 1 METHYLPYRAZOL 5 YL)XANTHINE; ADENOSINE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING COMPETITION; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONCENTRATION RESPONSE; CRYSTALLIZATION; DRUG BINDING; DRUG POTENCY; DRUG PURIFICATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC TRANSFECTION; IC 50; IN VITRO STUDY; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; BENZIMIDAZOLES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2B; XANTHINES;

EID: 84856405481     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201292w     Document Type: Article

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