A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4189-4192

  Yan, Yu ^a   Liu, Zijie ^a   Zhang, Jianjun ^a   Xu, Ruiming ^a   Hu, Xiao ^a   Liu, Gang ^a,b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b Tsinghua University   (China)

Author keywords

Benzimidazole; DFDNB; H+ K+ ATP enzyme inhibitors; Solution phase synthesis

Indexed keywords

2 [(2 PYRIDYLMETHYL)SULFINYL]BENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION;

BENZIMIDAZOLES; H(+)-K(+)-EXCHANGING ATPASE; PROTON PUMP INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES;

EID: 79959907243     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.080     Document Type: Article

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