Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7493-7500

  Mayence, Annie ^a   Vanden Eynde, Jean Jacques ^a,b   Kaiser, Marcel ^c,d   Brun, Reto ^c,d   Yarlett, Nigel ^e   Huang, Tien L ^a  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b UNIVERSITY OF MONS   (Belgium)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e PACE UNIVERSITY   (United States)

Author keywords

Benzimidazole; Malaria; Plasmodium; Protozoan parasites

Indexed keywords

2,2' [1,10 DECANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,10 DECANEDIYLBIS(OXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,2 ETHANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,2 ETHANEDIYLBIS(OXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,2 PHENYLENEBIS(METHYLENEOXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,2 PHENYLENEBIS(METHYLENEOXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,2 PROPANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,3 PHENYLENEBIS(METHYLENEOXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,3 PHENYLENEBIS(METHYLENEOXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,4 BUTANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,4 PHENYLENEBIS(METHYLENEOXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,4 PHENYLENEBIS(METHYLENEOXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,6 HEXANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,7 HEPTANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,8 OCTANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,8 OCTANEDIYLBIS(OXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,9 NONANEDIYLBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [1,9 NONANEDIYLBIS(OXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [ALKANE ALPHA,OMEGA DIYLBIS(OXYPHENYLENE)]BIS 1H BENZIMIDAZOLE DERIVATIVE; 2,2' [METHYLENEBIS(OXY 1,3 PHENYLENE)]BIS 1H BENZIMIDAZOLE; 2,2' [METHYLENEBIS(OXY 1,4 PHENYLENE)]BIS 1H BENZIMIDAZOLE; ANTIPROTOZOAL AGENT; BENZIMIDAZOLE DERIVATIVE; BENZNIDAZOLE; CHLOROQUINE; MELARSOPROL; METRONIDAZOLE; MILTEFOSINE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; DRUG STRUCTURE; ENTAMOEBA HISTOLYTICA; GIARDIA LAMBLIA; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; MYOBLAST; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIMALARIALS; BENZIMIDAZOLES; CELL LINE; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; RATS;

ENTAMOEBA HISTOLYTICA; GIARDIA INTESTINALIS; LEISHMANIA DONOVANI; PLASMODIUM FALCIPARUM; PROTOZOA; RATTUS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 82255183050     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.039     Document Type: Article

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