Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1774-1778

  Wu, Zhicai ^a   Yang, Cangming ^a   Xiong, Yusheng ^a   Feng, Zhe ^a   Lombardo, Matthew ^a   Verras, Andreas ^a   Chabin, Renee M ^a   Xu, Suoyu ^a   Tong, Xinchun ^a   Xie, Dan ^a   Lassman, Mike E ^a   Bhatt, Urmi R ^a   Garcia Calvo, Margarita M ^a   Geissler, Wayne ^a   Shen, Zhu ^a   Chen, Qing ^a   Sinharoy, Ranabir ^a   Hale, Jeffrey J ^a   Tata, James R ^a   Pinto, Shirly ^a   Shen, Dong Ming ^a   Colletti, Steven L ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Inhibitor; Obesity; Prolylcarboxypeptidase (PrCP)

Indexed keywords

ALANINE DERIVATIVE; PEPTIDE HYDROLASE INHIBITOR; PROLINE CARBOXYPEPTIDASE; PROLYLCARBOXYPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COMPARATIVE STUDY; DRUG ACTIVITY; HUMAN; MOUSE; NONHUMAN; OBESITY; STRUCTURE ACTIVITY RELATION;

EID: 84862803977     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.064     Document Type: Article

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