Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4218-4224

  Zhu, Jinmei ^a   Wu, Chun Feng ^b   Li, Xiaobing ^a   Wu, Gui Sheng ^c   Xie, Shan ^a   Hu, Qian Nan ^a   Deng, Zixin ^a   Zhu, Michael X ^d   Luo, Huai Rong ^b   Hong, Xuechuan ^a  

^a WUHAN UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

2 Aminobenzimidazole; Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Molecular modeling

Indexed keywords

1 (1H BENZO[D]IMIDAZOL 2 YL) 1,2,3,4 TETRAHYDROQUINOLINE; 2 (2 METHYLPIPERIDIN 1 YL) 1H BENZO[D]IMIDAZOLE; 2 (PIPERIDIN 1 YL) 1H BENZO[D]IMIDAZOLE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALANINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; HISTIDINE; N (2 METHOXYETHYL) 1H BENZO[D]IMIDAZOL 2 AMINE; N (3 PHENYLPROPYL) 1H BENZO[D]IMIDAZOL 2 AMINE; N (ADAMANTAN 1 YL) 1H BENZO[D]IMIDAZOL 2 AMINE; N (PYRIDIN 2 YL) 1H BENZO[D]IMIDAZOL 2 AMINE; N BUTYL 1 METHYL 1H BENZO[D]IMIDAZOL 2 AMINE; N BUTYL N METHYL 1H BENZO[D]IMIDAZOL 2 AMINE; N BUTYL N,1 DIMETHYL 1H BENZO[D]IMIDAZOL 2 AMINE; N1 (1H BENZO[D]IMIDAZOL 2 YL) N3,N3 DIETHYLPROPANE 1,3 DIAMINE; N1,N1 BIS(1H BENZO[D]IMIDAZOL 2 YL) N3,N3 DIMETHYLPROPANE 1,3 DIAMINE; TACRINE; TERT BUTYL [2 [(1H BENZO[D]IMIDAZOL 2 YL)AMINO]ETHYL]CARBAMATE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR MODEL; SUBSTITUTION REACTION;

ACETYLCHOLINESTERASE; ANIMALS; BENZIMIDAZOLES; BINDING SITES; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN BINDING; RATS;

EID: 84879023330     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.001     Document Type: Article

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