Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3523-3530

  Zheng, Youguang ^a   Zheng, Ming ^b   Ling, Xin ^a   Liu, Yi ^a   Xue, Yunsheng ^a   An, Lin ^a   Gu, Ning ^b   Jin, Min ^b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Aurora A B kinase; Molecular modeling; Pyrazole benzimidazole derivatives; Quantum chemical studies

Indexed keywords

AURORA A KINASE; AURORA B KINASE; AURORA KINASE INHIBITOR; BENZIMIDAZOLE DERIVATIVE; HYDROGEN; PYRAZOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MOLECULAR MODEL; QUANTUM CHEMISTRY; STRUCTURE ACTIVITY RELATION;

AURORA KINASE A; AURORA KINASE B; BENZIMIDAZOLES; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PYRAZOLES; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878105567     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.039     Document Type: Article

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