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Volumn 20, Issue 24, 2012, Pages 7069-7082
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Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
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Author keywords
Antimicrobial; Methicillin resistant Staphylococcus aureus; Pyruvate kinase inhibitor; Structure activity relationships
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Indexed keywords
4 HYDROXY N' [1 (1H INDOL 2 YL)ETHYLIDENE] 1,1' BIPHENYL 3 CARBOHYDRAZIDE;
5 BROMO 2 HYDROXY N' [1 (4,5,6 TRIFLUORO 1H INDOL 2 YL)ETHYLIDENE]BENZOHYDRAZIDE;
5 BROMO 2 HYDROXY N' [1 (5 HYDROXY 1H INDOL 2 YL)ETHYLIDENE]BENZOHYDRAZIDE;
5 BROMO 2 HYDROXY N' [1 (5 IODO 1H INDOL 2 YL)ETHYLIDENE]BENZOHYDRAZIDE;
5 BROMO 2 HYDROXY N' [1 (5 METHOXY 1H INDOL 2 YL)ETHYLIDENE]BENZOHYDRAZIDE;
5 BROMO 2 HYDROXY N' [1 (5 PHENYL 1H INDOL 2 YL)ETHYLIDENE]BENZOHYDRAZIDE;
5 BROMO 2 HYDROXY N' [1 [5 (TRIFLUOROMETHYL) 1H INDOL 2 YL]ETHYLIDENE]BENZOHYDRAZIDE;
5 BROMO N' [1 (4,5 DIFLUORO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
5 BROMO N' [1 (5 BROMO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
5 BROMO N' [1 (5 CHLORO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
5 BROMO N' [1 (5 FLUORO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
5 BROMO N' [1 (5,6 DIFLUORO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
5 BROMO N' [1 (6 BROMO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
5 BROMO N' [1 (7 FLUORO 1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
ANTIINFECTIVE AGENT;
HYDRAZONE DERIVATIVE;
N' [(1H INDOL 2 YL)(PHENYL)METHYLENE] 5 BROMO 2 HYDROXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL) 2,2 DIMETHYLPROPYLIDENE] 5 BROMO 2 HYDROXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXY 5 IODOBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 2 HYDROXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 3 BROMOBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 4 BROMO 2 HYDROXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 5 BROMO 2 ETHOXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 5 BROMO 2 HYDROXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE] 5 BROMO 2 METHOXYBENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE]BENZOHYDRAZIDE;
N' [1 (1H INDOL 2 YL)ETHYLIDENE]PICOLINOHYDRAZIDE;
PYRUVATE KINASE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
VANCOMYCIN;
ANTIBACTERIAL ACTIVITY;
ARTICLE;
BACTERIAL GROWTH;
CONTROLLED STUDY;
DRUG CYTOTOXICITY;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;
MINIMUM INHIBITORY CONCENTRATION;
NONHUMAN;
STRUCTURE ACTIVITY RELATION;
ANTI-INFECTIVE AGENTS;
HUMANS;
METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS;
MODELS, MOLECULAR;
PROTEIN KINASE INHIBITORS;
PYRUVATE KINASE;
STRUCTURE-ACTIVITY RELATIONSHIP;
BACTERIA (MICROORGANISMS);
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;
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EID: 84870064229
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.10.002 Document Type: Article |
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Times cited : (29)
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References (8)
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